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- W4311135320 abstract "Developing chemiluminescence probe with a slow kinetic profile, even a constant emission within analytical time, would improve the analytical sensitivity, but still remains challenging. This work reports a novel strategy to afford long-lasting in vivo imaging by developing a self-assembled chemiluminophore HPQCL-Cl via the introduction of the hydrogen-bond-driven self-assembled dye HPQ to Schaap's dioxetane. Compared with classical chemiluminophore HCL, self-assembled HPQCL-Cl was isolated from the physiological environment, thereby lowering its deprotonation and prolonging its half-life. Based on HPQCL-Cl, the long-lasting in vivo imaging of 9L-lacz tumor was achieved by developing a β-gal-responsive probe. Its signals remained constant (<5% change) for about 20 min, which may provide a wide time window for the determination of β-gal. This probe also showed high tumor-to-normal tissue ratio throughout tumor resection, highlighting its potential in image-guided clinical surgery." @default.
- W4311135320 created "2022-12-23" @default.
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- W4311135320 date "2023-02-01" @default.
- W4311135320 modified "2023-10-17" @default.
- W4311135320 title "Hydrogen-bond-driven self-assembly of chemiluminophore affording long-lasting in vivo imaging" @default.
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- W4311135320 doi "https://doi.org/10.1016/j.biomaterials.2022.121955" @default.
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