FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311138680> ?p ?o ?g. }

• W4311138680 endingPage "41" @default.
• W4311138680 startingPage "35" @default.
• W4311138680 abstract "To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine (TCM) based on the regulation of gene expression. Genome-wide gene expression profiles of Michigan Cancer Foundation-7 (MCF-7) cells treated with or without 4 cholic acid derivatives were detected by gene chip technology. Similarities in upregulated and downregulated genes were analyzed using the Connectivity Map (CMap) database. The affinity between cholic acid derivatives and the potential target was confirmed by molecular docking. The cholic acid derivative-regulated pathway enrichment analysis was performed by the STRING database, and the potential pathway was confirmed by in vitro experiments on MD Anderson-Metastatic Breast-231 (MDA-MB-231) cells. Compared with the reference genome in the CMap database, the gene expression profiles of cholic acid derivatives were similar to those of antipsychotic, anticancer, anti-inflammatory, and anti-infective drugs. Among them, 4 derivatives were associated with antianxiety drugs, and molecular docking results showed that these compounds may act by binding to the ligand-binding site of gamma-aminobutyric acid (GABA) receptors. Moreover, the cytoskeletal pathway is one of the pathways enriched in the derivatives. Of them, ursodeoxycholic acid showed significant inhibitory activity on the cytoskeleton formation of MDA-MB-231 cells. The gene expression detection method, combined with CMap and pathway enrichment analysis, could be used to study the mechanism of the active ingredients of TCM. In addition, our research showed that cholic acid derivatives have a potential affinity for membrane receptors, where they can exert anxiolytic activity by modulating opioid receptor, GABA receptor, and dopamine receptor. Moreover, ursodeoxycholic and chenodeoxycholic acid inhibit cytoskeleton formation, probably by acting on membrane proteins to activate the corresponding cytoskeletal pathways." @default.
• W4311138680 created "2022-12-23" @default.
• W4311138680 creator A5000012635 @default.
• W4311138680 creator A5010614508 @default.
• W4311138680 creator A5073423543 @default.
• W4311138680 creator A5073501391 @default.
• W4311138680 creator A5082575859 @default.
• W4311138680 creator A5083181758 @default.
• W4311138680 date "2023-01-01" @default.
• W4311138680 modified "2023-10-01" @default.
• W4311138680 title "Study on the mechanism of cholic acid derivatives in traditional Chinese medicine based on the regulation of gene expression" @default.
• W4311138680 cites W1509405108 @default.
• W4311138680 cites W1871114014 @default.
• W4311138680 cites W1976235901 @default.
• W4311138680 cites W1977317463 @default.
• W4311138680 cites W1982285593 @default.
• W4311138680 cites W1984345984 @default.
• W4311138680 cites W1985106253 @default.
• W4311138680 cites W2000189716 @default.
• W4311138680 cites W2003756447 @default.
• W4311138680 cites W2012065014 @default.
• W4311138680 cites W2034445006 @default.
• W4311138680 cites W2046676505 @default.
• W4311138680 cites W2055067222 @default.
• W4311138680 cites W2066561101 @default.
• W4311138680 cites W2091554687 @default.
• W4311138680 cites W2121604817 @default.
• W4311138680 cites W2172202192 @default.
• W4311138680 cites W2284357204 @default.
• W4311138680 cites W2316970164 @default.
• W4311138680 cites W2319464753 @default.
• W4311138680 cites W2536739187 @default.
• W4311138680 cites W2589999763 @default.
• W4311138680 cites W2767618691 @default.
• W4311138680 cites W2771832319 @default.
• W4311138680 cites W2784137104 @default.
• W4311138680 cites W2791602796 @default.
• W4311138680 cites W2792156178 @default.
• W4311138680 cites W3000308044 @default.
• W4311138680 cites W3022109193 @default.
• W4311138680 cites W3049223030 @default.
• W4311138680 cites W3082314931 @default.
• W4311138680 cites W3107527779 @default.
• W4311138680 cites W3113179625 @default.
• W4311138680 cites W3199077271 @default.
• W4311138680 cites W3209782728 @default.
• W4311138680 cites W3212930235 @default.
• W4311138680 cites W4200305728 @default.
• W4311138680 cites W4295755448 @default.
• W4311138680 doi "https://doi.org/10.1016/j.jtcms.2022.11.001" @default.
• W4311138680 hasPublicationYear "2023" @default.
• W4311138680 type Work @default.
• W4311138680 citedByCount "0" @default.
• W4311138680 crossrefType "journal-article" @default.
• W4311138680 hasAuthorship W4311138680A5000012635 @default.
• W4311138680 hasAuthorship W4311138680A5010614508 @default.
• W4311138680 hasAuthorship W4311138680A5073423543 @default.
• W4311138680 hasAuthorship W4311138680A5073501391 @default.
• W4311138680 hasAuthorship W4311138680A5082575859 @default.
• W4311138680 hasAuthorship W4311138680A5083181758 @default.
• W4311138680 hasBestOaLocation W43111386801 @default.
• W4311138680 hasConcept C104317684 @default.
• W4311138680 hasConcept C150194340 @default.
• W4311138680 hasConcept C170493617 @default.
• W4311138680 hasConcept C185592680 @default.
• W4311138680 hasConcept C202751555 @default.
• W4311138680 hasConcept C2775900799 @default.
• W4311138680 hasConcept C2776120743 @default.
• W4311138680 hasConcept C2779399885 @default.
• W4311138680 hasConcept C55493867 @default.
• W4311138680 hasConcept C86803240 @default.
• W4311138680 hasConcept C98274493 @default.
• W4311138680 hasConceptScore W4311138680C104317684 @default.
• W4311138680 hasConceptScore W4311138680C150194340 @default.
• W4311138680 hasConceptScore W4311138680C170493617 @default.
• W4311138680 hasConceptScore W4311138680C185592680 @default.
• W4311138680 hasConceptScore W4311138680C202751555 @default.
• W4311138680 hasConceptScore W4311138680C2775900799 @default.
• W4311138680 hasConceptScore W4311138680C2776120743 @default.
• W4311138680 hasConceptScore W4311138680C2779399885 @default.
• W4311138680 hasConceptScore W4311138680C55493867 @default.
• W4311138680 hasConceptScore W4311138680C86803240 @default.
• W4311138680 hasConceptScore W4311138680C98274493 @default.
• W4311138680 hasFunder F4320321001 @default.
• W4311138680 hasIssue "1" @default.
• W4311138680 hasLocation W43111386801 @default.
• W4311138680 hasOpenAccess W4311138680 @default.
• W4311138680 hasPrimaryLocation W43111386801 @default.
• W4311138680 hasRelatedWork W1868808302 @default.
• W4311138680 hasRelatedWork W1969040028 @default.
• W4311138680 hasRelatedWork W2014335245 @default.
• W4311138680 hasRelatedWork W2052968567 @default.
• W4311138680 hasRelatedWork W2113892157 @default.
• W4311138680 hasRelatedWork W2344075400 @default.
• W4311138680 hasRelatedWork W2791899145 @default.
• W4311138680 hasRelatedWork W2884552272 @default.
• W4311138680 hasRelatedWork W2948302576 @default.
• W4311138680 hasRelatedWork W4312343655 @default.

• next