Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311142316> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4311142316 abstract "Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected almost all countries. The unprecedented spreading of this virus has led to the insurgence of many variants that impact protein sequence and structure that need continuous monitoring and analysis of the sequences to understand the genetic evolution and to prevent possible dangerous outcomes. Some variants causing the modification of the structure of the proteins, such as the Spike protein S, need to be monitored. Protein contact networks (PCNs) have been recently proposed as a modelling framework for protein structures. In such a framework, the protein structure is represented as an unweighted graph whose nodes are the central atoms of the backbones (C- α ), and edges connect two atoms falling in the spatial distance between 4 and 7 Å. PCN may also be a data-rich representation since we may add to each node/atom biological and topological information. Such formalism enables the possibility of using algorithms from graph theory to analyze the graph. In particular, we refer to graph embedding methods enabling the analysis of such graphs with deep learning methods. In this work, we explore the possibility of embedding PCN using Graph Neural Networks and then analyze in the embedded space each residue to distinguish mutated residues from non-mutated ones. In particular, we analyzed the structure of the Spike protein of the coronavirus. First, we obtained the PCNs of the Spike protein for the wild-type, α , β , and δ variants. Then we used the GraphSage embedding algorithm to obtain an unsupervised embedding. Then we analyzed the point of mutation in the embedded space. Results show the characteristics of the mutation point in the embedding space." @default.
- W4311142316 created "2022-12-23" @default.
- W4311142316 creator A5027369094 @default.
- W4311142316 creator A5037399554 @default.
- W4311142316 creator A5059223728 @default.
- W4311142316 creator A5063002790 @default.
- W4311142316 date "2022-12-02" @default.
- W4311142316 modified "2023-09-27" @default.
- W4311142316 title "Structural analysis of SARS-CoV-2 Spike protein variants through graph embedding" @default.
- W4311142316 cites W2037589601 @default.
- W4311142316 cites W2043046112 @default.
- W4311142316 cites W2065670043 @default.
- W4311142316 cites W2066162606 @default.
- W4311142316 cites W2084613253 @default.
- W4311142316 cites W2168770860 @default.
- W4311142316 cites W2325652290 @default.
- W4311142316 cites W2569705007 @default.
- W4311142316 cites W2607500032 @default.
- W4311142316 cites W2786016794 @default.
- W4311142316 cites W2962756421 @default.
- W4311142316 cites W3013395653 @default.
- W4311142316 cites W3022285953 @default.
- W4311142316 cites W3083992405 @default.
- W4311142316 cites W3104097132 @default.
- W4311142316 cites W3105705953 @default.
- W4311142316 cites W3128563282 @default.
- W4311142316 cites W3131070495 @default.
- W4311142316 cites W3131708129 @default.
- W4311142316 cites W3177828909 @default.
- W4311142316 cites W4200140556 @default.
- W4311142316 cites W4214721934 @default.
- W4311142316 cites W4225124585 @default.
- W4311142316 cites W4284899542 @default.
- W4311142316 doi "https://doi.org/10.1007/s13721-022-00397-9" @default.
- W4311142316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36506261" @default.
- W4311142316 hasPublicationYear "2022" @default.
- W4311142316 type Work @default.
- W4311142316 citedByCount "0" @default.
- W4311142316 crossrefType "journal-article" @default.
- W4311142316 hasAuthorship W4311142316A5027369094 @default.
- W4311142316 hasAuthorship W4311142316A5037399554 @default.
- W4311142316 hasAuthorship W4311142316A5059223728 @default.
- W4311142316 hasAuthorship W4311142316A5063002790 @default.
- W4311142316 hasBestOaLocation W43111423161 @default.
- W4311142316 hasConcept C10010492 @default.
- W4311142316 hasConcept C104317684 @default.
- W4311142316 hasConcept C132525143 @default.
- W4311142316 hasConcept C154945302 @default.
- W4311142316 hasConcept C167625842 @default.
- W4311142316 hasConcept C41008148 @default.
- W4311142316 hasConcept C41608201 @default.
- W4311142316 hasConcept C54355233 @default.
- W4311142316 hasConcept C70721500 @default.
- W4311142316 hasConcept C75564084 @default.
- W4311142316 hasConcept C80444323 @default.
- W4311142316 hasConcept C86803240 @default.
- W4311142316 hasConceptScore W4311142316C10010492 @default.
- W4311142316 hasConceptScore W4311142316C104317684 @default.
- W4311142316 hasConceptScore W4311142316C132525143 @default.
- W4311142316 hasConceptScore W4311142316C154945302 @default.
- W4311142316 hasConceptScore W4311142316C167625842 @default.
- W4311142316 hasConceptScore W4311142316C41008148 @default.
- W4311142316 hasConceptScore W4311142316C41608201 @default.
- W4311142316 hasConceptScore W4311142316C54355233 @default.
- W4311142316 hasConceptScore W4311142316C70721500 @default.
- W4311142316 hasConceptScore W4311142316C75564084 @default.
- W4311142316 hasConceptScore W4311142316C80444323 @default.
- W4311142316 hasConceptScore W4311142316C86803240 @default.
- W4311142316 hasIssue "1" @default.
- W4311142316 hasLocation W43111423161 @default.
- W4311142316 hasLocation W43111423162 @default.
- W4311142316 hasLocation W43111423163 @default.
- W4311142316 hasOpenAccess W4311142316 @default.
- W4311142316 hasPrimaryLocation W43111423161 @default.
- W4311142316 hasRelatedWork W2893186803 @default.
- W4311142316 hasRelatedWork W2923818335 @default.
- W4311142316 hasRelatedWork W3035116611 @default.
- W4311142316 hasRelatedWork W3044354590 @default.
- W4311142316 hasRelatedWork W3149439221 @default.
- W4311142316 hasRelatedWork W4212923699 @default.
- W4311142316 hasRelatedWork W4213133066 @default.
- W4311142316 hasRelatedWork W4285120483 @default.
- W4311142316 hasRelatedWork W4287763734 @default.
- W4311142316 hasRelatedWork W4323323198 @default.
- W4311142316 hasVolume "12" @default.
- W4311142316 isParatext "false" @default.
- W4311142316 isRetracted "false" @default.
- W4311142316 workType "article" @default.