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• W4311142912 endingPage "114399" @default.
• W4311142912 startingPage "114399" @default.
• W4311142912 abstract "The similar nervous system structure between crustaceans and insects and the high-water solubility of thiamethoxam can lead to the more severe toxicity of thiamethoxam to crustaceans. However, the effects of thiamethoxam on crustaceans are unclear. Therefore, a 96-h acute toxicity test was performed to explore the hepatotoxicity and neurotoxicity effects of thiamethoxam on Chinese mitten crab (Eriocheir sinensis) at concentrations 0 µg/L, 150 µg/L and 300 µg/L. The antioxidant and detoxification systems (including phases I and II) were significantly activated after exposure of juvenile crabs to thiamethoxam for 24 h in 300 µg/L group, whereas the toxic activation effect in 150 μg/L group was delayed. Moreover, a similar pattern was observed for the transcription levels of immune-related genes. Further analysis of inflammatory signaling pathway-related genes showed that thiamethoxam exposure with 300 µg/L for 24 h may induce a pro-inflammatory response through the NF-κB pathway. In contrast, the gene expression levels in 150 µg/L group were significantly upregulated compared with 0 µg/L group after 96 h. In addition, although the acute exposure of 150 μg/L thiamethoxam did not seem to induce significant neurotoxicity, the acetylcholinesterase activity was significantly decreased in 300 μg/L group after thiamethoxam exposure for 96 h. Correspondingly, thiamethoxam exposure with 300 µg/L for 24 h resulted in significantly downregulated transcriptional levels of synaptic transmission-related genes (e.g. dopamine-, gamma-aminobutyric acid- and serotonin-related receptors). Therefore, thiamethoxam may be harmful and cause potential toxic threats such as neurotoxicity and metabolic damage to crustaceans." @default.
• W4311142912 created "2022-12-23" @default.
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• W4311142912 date "2023-01-01" @default.
• W4311142912 modified "2023-10-15" @default.
• W4311142912 title "Acute thiamethoxam exposure induces hepatotoxicity and neurotoxicity in juvenile Chinese mitten crab (Eriocheir sinensis)" @default.
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• W4311142912 doi "https://doi.org/10.1016/j.ecoenv.2022.114399" @default.
• W4311142912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36508784" @default.
• W4311142912 hasPublicationYear "2023" @default.
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