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- W4311146549 abstract "One of the main reasons for the low efficiency of immunotherapy with immune checkpoint inhibitors in non-inflamed (cold) tumors is the lack of anti-tumoral T cell responses. Arenavirus-based cancer vaccines are ideally suited to induce tumor specific T cells but are hampered by the presence of immunosuppressive factors within the tumor microenvironment. Due to their capacity to promote activation, expansion, and effector function of activated T cells, we hypothesized that 4-1BB agonists could help to overcome intratumoral immune suppression by maintaining or even enhancing the functionality of vector-induced T cell responses." @default.
- W4311146549 created "2022-12-23" @default.
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- W4311146549 date "2022-12-01" @default.
- W4311146549 modified "2023-09-28" @default.
- W4311146549 title "53P Combining cancer vaccines based on arenavirus vectors with 4-1BB (CD137) agonists enhances therapeutic efficacy in a non-inflamed tumor model" @default.
- W4311146549 doi "https://doi.org/10.1016/j.iotech.2022.100158" @default.
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