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• W4311147282 endingPage "122469" @default.
• W4311147282 startingPage "122469" @default.
• W4311147282 abstract "Pharmaceutical product development guided by Quality by Design (QbD) is based on a complete understanding of the critical process parameters (CPPs) that are important for achieving the desired product critical quality attributes (CQAs). The effect of process settings, such as the screw speed, the throughput, the barrel temperature, and the screw configuration, is a well-known factor in the setup of pharmaceutical hot melt extrusion (HME) processes. A CPP that has not yet been extensively researched is the type of cross-section geometry of the screw elements. Typically, pharmaceutical extruders have double-flighted screw cross-sections, with some elements having a single- or triple-flighted element section. The exception is a NANO16 extruder from Leistritz, with all screw elements having a triple-flighted screw geometry. We investigated the process setup and scale-up to a double-flighted extruder experimentally and in silico via a digital twin. Two formulations were processed on a NANO16 extruder and virtually transferred to a ZSE18 double-flighted co-rotating twin-screw extruder. Detailed smoothed particle hydrodynamics simulations of all screw elements available from both extruders were performed, and their efficiency in conveying, pressure build-up, and power consumption were studied. Reduced-order 1D HME simulations, which were carried out to investigate the process space and scalability of both extruders, were experimentally validated." @default.
• W4311147282 created "2022-12-23" @default.
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• W4311147282 date "2023-01-01" @default.
• W4311147282 modified "2023-10-01" @default.
• W4311147282 title "Pharmaceutical hot melt extrusion process development using QbD and digital twins" @default.
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• W4311147282 doi "https://doi.org/10.1016/j.ijpharm.2022.122469" @default.
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• W4311147282 hasPublicationYear "2023" @default.
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