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• W4311153983 abstract "Evolutionarily conserved insulin/insulin-like growth factor (IGF) signaling (IIS) correlates nutrient levels to metabolism and growth, thereby playing crucial roles in development and adult fitness. In the fruit fly Drosophila, ImpL2, an ortholog of IGFBP7, binds to and inhibits the function of Drosophila insulin-like peptides. In this study, we isolated a temperature-sensitive mutation in the insulin receptor (InR) gene as a spontaneous revertant in ImpL2 null mutants. The p.Y902C missense mutation is located at the functionally conserved amino acid residue of the first fibronectin type III domain of InR. The hypomorphic InR mutant animals showed a temperature-dependent reduction in IIS and body size. The mutant animals also exhibited metabolic defects, such as increased triglyceride and carbohydrate levels. Metabolomic analysis further revealed that defects in InR caused dysregulation of amino acid and ribonucleotide metabolism. We also observed that InR mutant females produced tiny irregular-shaped embryos with reduced fecundity. In summary, this novel allele of InR is a valuable tool for the Drosophila genetic model of insulin resistance and type 2 diabetes." @default.
• W4311153983 created "2022-12-24" @default.
• W4311153983 creator A5060612254 @default.
• W4311153983 creator A5086617146 @default.
• W4311153983 date "2023-01-01" @default.
• W4311153983 modified "2023-10-11" @default.
• W4311153983 title "Isolation of a novel missense mutation in <i>insulin receptor</i> as a spontaneous revertant in <i>ImpL2</i> mutants in <i>Drosophila</i>" @default.
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• W4311153983 doi "https://doi.org/10.1242/dev.201248" @default.
• W4311153983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36504086" @default.
• W4311153983 hasPublicationYear "2023" @default.
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