Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311156516> ?p ?o ?g. }
- W4311156516 abstract "Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Such antibodies are typically non-opsonic. However, one antibody could effectively promote vital immune functions, including phagocytosis and in vivo protection. Remarkably, this antibody primarily interacts through a bivalent dual-Fab cis mode, where the Fabs bind to two distinct epitopes in the M protein. The dual-Fab cis-binding phenomenon is conserved across different groups of M types. In contrast, other antibodies binding with normal single-Fab mode to the same region cannot bypass the M protein's virulent effects. A broadly binding, protective monoclonal antibody could be a candidate for anti-streptococcal therapy. Our findings highlight the concept of dual-Fab cis binding as a means to access conserved, and normally non-opsonic regions, regions for protective antibody targeting." @default.
- W4311156516 created "2022-12-24" @default.
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- W4311156516 date "2022-12-12" @default.
- W4311156516 modified "2023-10-09" @default.
- W4311156516 title "A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function" @default.
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- W4311156516 doi "https://doi.org/10.15252/emmm.202216208" @default.
- W4311156516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36507602" @default.
- W4311156516 hasPublicationYear "2022" @default.
- W4311156516 type Work @default.