Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311164920> ?p ?o ?g. }
- W4311164920 abstract "Abstract Purpose Gastric cancer (GC) is a malignant tumour with high mortality, and liver metastasis is one of the main causes of poor prognosis. SLIT- and NTRK-like family member 4 ( SLITRK4 ) plays an important role in the nervous system, such as synapse formation. Our study aimed to explore the functional role of SLITRK4 in GC and liver metastasis. Methods The mRNA level of SLITRK4 was evaluated using publicly available transcriptome GEO datasets and Renji cohort. The protein level of SLITRK4 in the tissue microarray of GC was observed using immunohistochemistry. Cell Counting Kit-8, colony formation, transwell migration assays in vitro and mouse model of liver metastatasis in vivo were performed to investigate the functional roles of SLITRK4 in GC. Bioinformatics predictions and Co-IP experiments were applied to screen and identify SLITRK4-binding proteins. Western blot was performed to detect TrkB-related signaling molecules. Results By comparing primary and liver metastases from GC, SLITRK4 was found to be upregulated in tissues of GC with liver metastasis and to be closely related to poor clinical prognosis. SLITRK4 knockdown significantly abrogated the growth, invasion, and metastasis of GC in vitro and in vivo . Further study revealed that SLITRK4 could interact with Canopy FGF Signalling Regulator 3 (CNPY3), thus enhancing TrkB-related signaling by promoting the endocytosis and recycling of the TrkB receptor. Conclusion In conclusion, the CNPY3-SLITRK axis contributes to liver metastasis of GC according to the TrkB-related signaling pathway. which may be a therapeutic target for the treatment of GC with liver metastasis." @default.
- W4311164920 created "2022-12-24" @default.
- W4311164920 creator A5000096352 @default.
- W4311164920 creator A5005806917 @default.
- W4311164920 creator A5006016257 @default.
- W4311164920 creator A5012793599 @default.
- W4311164920 creator A5016735063 @default.
- W4311164920 creator A5021899470 @default.
- W4311164920 creator A5033806327 @default.
- W4311164920 creator A5034787589 @default.
- W4311164920 creator A5040527606 @default.
- W4311164920 creator A5050832605 @default.
- W4311164920 creator A5052493382 @default.
- W4311164920 creator A5053780153 @default.
- W4311164920 creator A5059336113 @default.
- W4311164920 creator A5067429755 @default.
- W4311164920 creator A5071426920 @default.
- W4311164920 creator A5087335378 @default.
- W4311164920 creator A5087399382 @default.
- W4311164920 creator A5091107085 @default.
- W4311164920 date "2022-12-07" @default.
- W4311164920 modified "2023-10-18" @default.
- W4311164920 title "The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells" @default.
- W4311164920 cites W1950118853 @default.
- W4311164920 cites W1964793822 @default.
- W4311164920 cites W1976037153 @default.
- W4311164920 cites W1983077959 @default.
- W4311164920 cites W1989810154 @default.
- W4311164920 cites W2001422697 @default.
- W4311164920 cites W2007878268 @default.
- W4311164920 cites W2047757988 @default.
- W4311164920 cites W2102399874 @default.
- W4311164920 cites W2119392480 @default.
- W4311164920 cites W2139871765 @default.
- W4311164920 cites W2146530991 @default.
- W4311164920 cites W2266814182 @default.
- W4311164920 cites W2310968520 @default.
- W4311164920 cites W2480850165 @default.
- W4311164920 cites W2515149348 @default.
- W4311164920 cites W2533419167 @default.
- W4311164920 cites W2537421021 @default.
- W4311164920 cites W2592504006 @default.
- W4311164920 cites W2596133050 @default.
- W4311164920 cites W2612174965 @default.
- W4311164920 cites W2762342558 @default.
- W4311164920 cites W2784132648 @default.
- W4311164920 cites W2915753622 @default.
- W4311164920 cites W2916895013 @default.
- W4311164920 cites W2954136062 @default.
- W4311164920 cites W2967687621 @default.
- W4311164920 cites W2986789573 @default.
- W4311164920 cites W2999990233 @default.
- W4311164920 cites W3006038421 @default.
- W4311164920 cites W3008403778 @default.
- W4311164920 cites W3009431768 @default.
- W4311164920 cites W3026620415 @default.
- W4311164920 cites W3037458097 @default.
- W4311164920 cites W3047438447 @default.
- W4311164920 cites W3119979423 @default.
- W4311164920 cites W3127321332 @default.
- W4311164920 cites W3128646645 @default.
- W4311164920 cites W3138641935 @default.
- W4311164920 cites W3159512579 @default.
- W4311164920 cites W3183629204 @default.
- W4311164920 cites W3192104447 @default.
- W4311164920 cites W3194519005 @default.
- W4311164920 cites W4210990885 @default.
- W4311164920 cites W4211007657 @default.
- W4311164920 cites W4211037511 @default.
- W4311164920 cites W4211255759 @default.
- W4311164920 cites W4283735263 @default.
- W4311164920 doi "https://doi.org/10.21203/rs.3.rs-2329872/v1" @default.
- W4311164920 hasPublicationYear "2022" @default.
- W4311164920 type Work @default.
- W4311164920 citedByCount "0" @default.
- W4311164920 crossrefType "posted-content" @default.
- W4311164920 hasAuthorship W4311164920A5000096352 @default.
- W4311164920 hasAuthorship W4311164920A5005806917 @default.
- W4311164920 hasAuthorship W4311164920A5006016257 @default.
- W4311164920 hasAuthorship W4311164920A5012793599 @default.
- W4311164920 hasAuthorship W4311164920A5016735063 @default.
- W4311164920 hasAuthorship W4311164920A5021899470 @default.
- W4311164920 hasAuthorship W4311164920A5033806327 @default.
- W4311164920 hasAuthorship W4311164920A5034787589 @default.
- W4311164920 hasAuthorship W4311164920A5040527606 @default.
- W4311164920 hasAuthorship W4311164920A5050832605 @default.
- W4311164920 hasAuthorship W4311164920A5052493382 @default.
- W4311164920 hasAuthorship W4311164920A5053780153 @default.
- W4311164920 hasAuthorship W4311164920A5059336113 @default.
- W4311164920 hasAuthorship W4311164920A5067429755 @default.
- W4311164920 hasAuthorship W4311164920A5071426920 @default.
- W4311164920 hasAuthorship W4311164920A5087335378 @default.
- W4311164920 hasAuthorship W4311164920A5087399382 @default.
- W4311164920 hasAuthorship W4311164920A5091107085 @default.
- W4311164920 hasBestOaLocation W43111649201 @default.
- W4311164920 hasConcept C104317684 @default.
- W4311164920 hasConcept C121608353 @default.
- W4311164920 hasConcept C126322002 @default.
- W4311164920 hasConcept C127561419 @default.
- W4311164920 hasConcept C150903083 @default.