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- W4311165622 abstract "Abstract Accumulating data have highlighted the role of monocytes/macrophages in immune escape by generating immunologically “cold” tumors that do not respond to immunotherapy. CD244 (SLAMF4, 2B4), a member of the signaling lymphocyte activation molecule family, is expressed on myeloid cells, but its precise role has not been elucidated. Using monocyte lineage-specific CD244-deficient (LysM-cre+/-CD244fl/fl;cKO) mice challenged with B16F10 melanoma, we report for the first time that CD244 negatively regulates tumor immunity by inhibiting the differentiation and functional maturation of CD11b + Ly6C hi F4/80 lo monocytes into CD11b + Ly6C lo F4/80 hi macrophages within the tumor microenvironment. CD244-deficient macrophages more effectively activated antigen-specific T cell responses compared to WT macrophages, thus delaying tumor growth in the B16F10 melanoma model. Moreover, combinatorial intervention of anti-PD-L1 antibodies with CD244-KO BMDM markedly improved tumor rejection compared to the anti-PD-L1 antibody alone or in combination with WT BMDM. Consistent with the murine data, transcriptome analysis of human melanoma tissue single-cell RNA-sequencing dataset (SCP398 from single-cell portal), revealed 221 differentially expressed genes of CD244 - monocytes/macrophages were associated with phagocytosis, antigen presentation, and autophagy. Additionally, cell type deconvolution analysis within melanoma patients bulk RNA-seq datasets from TCGA database, revealed presence of CD244- monocytes/macrophages significantly increased patient survival in primary and metastatic tumors. Hence, we proposed that CD244 serve as a critical immune checkpoint receptor on macrophages, and CD244-deficient macrophages may represent a novel therapeutic modality to convert immunologically “cold” tumors to “hot” tumors, which can function synergistically with checkpoint blockade therapies." @default.
- W4311165622 created "2022-12-24" @default.
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- W4311165622 date "2022-12-02" @default.
- W4311165622 modified "2023-09-30" @default.
- W4311165622 title "CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation" @default.
- W4311165622 cites W1535240987 @default.
- W4311165622 cites W1662706554 @default.
- W4311165622 cites W1910012553 @default.
- W4311165622 cites W1950535820 @default.
- W4311165622 cites W1950829641 @default.
- W4311165622 cites W1969057487 @default.
- W4311165622 cites W1981291019 @default.
- W4311165622 cites W1981431992 @default.
- W4311165622 cites W1985987855 @default.
- W4311165622 cites W1987165863 @default.
- W4311165622 cites W1996445489 @default.
- W4311165622 cites W1997286876 @default.
- W4311165622 cites W2005194145 @default.
- W4311165622 cites W2012232274 @default.
- W4311165622 cites W2012972418 @default.
- W4311165622 cites W2014472703 @default.
- W4311165622 cites W2016352485 @default.
- W4311165622 cites W2026829011 @default.
- W4311165622 cites W2029399624 @default.
- W4311165622 cites W2030123423 @default.
- W4311165622 cites W2035013975 @default.
- W4311165622 cites W2051095137 @default.
- W4311165622 cites W2059451663 @default.
- W4311165622 cites W2060672294 @default.
- W4311165622 cites W2061058669 @default.
- W4311165622 cites W2067759988 @default.
- W4311165622 cites W2077902753 @default.
- W4311165622 cites W2091898673 @default.
- W4311165622 cites W2093408909 @default.
- W4311165622 cites W2094981791 @default.
- W4311165622 cites W2101653483 @default.
- W4311165622 cites W2105709171 @default.
- W4311165622 cites W2108010609 @default.
- W4311165622 cites W2110373791 @default.
- W4311165622 cites W2112601576 @default.
- W4311165622 cites W2122440014 @default.
- W4311165622 cites W2122510983 @default.
- W4311165622 cites W2138547625 @default.
- W4311165622 cites W2142169541 @default.
- W4311165622 cites W2146774792 @default.
- W4311165622 cites W2152677909 @default.
- W4311165622 cites W2159751093 @default.
- W4311165622 cites W2160834915 @default.
- W4311165622 cites W2160985360 @default.
- W4311165622 cites W2241278454 @default.
- W4311165622 cites W2254573998 @default.
- W4311165622 cites W2403400382 @default.
- W4311165622 cites W2469213726 @default.
- W4311165622 cites W2509717357 @default.
- W4311165622 cites W2547310148 @default.
- W4311165622 cites W2563316422 @default.
- W4311165622 cites W2605934824 @default.
- W4311165622 cites W2615301036 @default.
- W4311165622 cites W2622024966 @default.
- W4311165622 cites W2761575992 @default.
- W4311165622 cites W2763186529 @default.
- W4311165622 cites W2782485041 @default.
- W4311165622 cites W2783617985 @default.
- W4311165622 cites W2784099979 @default.
- W4311165622 cites W2792191119 @default.
- W4311165622 cites W2899145148 @default.
- W4311165622 cites W2902074696 @default.
- W4311165622 cites W2914890099 @default.
- W4311165622 cites W2949177718 @default.
- W4311165622 cites W2951598503 @default.
- W4311165622 cites W2975736787 @default.
- W4311165622 cites W3013887655 @default.
- W4311165622 cites W3036958184 @default.
- W4311165622 cites W3040498796 @default.
- W4311165622 cites W3044905371 @default.
- W4311165622 cites W4207003083 @default.
- W4311165622 cites W4249980792 @default.
- W4311165622 doi "https://doi.org/10.1101/2022.12.01.518620" @default.