FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311173945> ?p ?o ?g. }

• W4311173945 endingPage "100129" @default.
• W4311173945 startingPage "100129" @default.
• W4311173945 abstract "Although miR-653-5p has been validated to participate in the progression of multiple types of cancer, the functional role of exosomal miR-653-5p derived from Mesenchymal Stem Cells (MSCs) in Laryngeal Papilloma (LP) has still remained elusive. Hence, this study aimed to investigate the role of MSCs-derived exosomal miR-653-5p in LP.LP tissues (n = 15) and adjacent normal tissues (n = 10) were collected to examine the expression level of miR-653-5p. The expression level of miR-653-5p in LP cells and normal cells was also detected. Then, miR-653-5p was overexpressed or silenced to explore its effects on the proliferation, migration, invasion, and apoptosis of LP cells. Thereafter, the effects of exosomal miR-653-5p derived from MSCs on LP cell progression and the potential regulatory mechanism of miR-653-5p were assessed.It was revealed that the expression level of miR-653-5p was downregulated in LP tissues and cells. In addition, miR-653-5p suppressed the proliferation, migration, invasion, and apoptosis of LP cells. Exosomes derived from MSCs played a suppressive role in LP development and mediated the transmission of miR-653-5p to LP cells. Further exploration identified Basic leucine Zipper and W2 domains 2 (BZW2) as the target of miR-653-5p. More importantly, the rescue experiments revealed that MSCs-secreted exosomal miR-653-5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells.MSCs-derived exosomal miR-653-5p exerted inhibitory effects on LP progression through targeting BZW2, which provided a novel idea for the therapy of LP.chictr-ior-17011021." @default.
• W4311173945 created "2022-12-24" @default.
• W4311173945 creator A5032020402 @default.
• W4311173945 creator A5039201527 @default.
• W4311173945 creator A5042704924 @default.
• W4311173945 creator A5046595612 @default.
• W4311173945 creator A5046738991 @default.
• W4311173945 creator A5055455443 @default.
• W4311173945 creator A5074789712 @default.
• W4311173945 date "2023-01-01" @default.
• W4311173945 modified "2023-09-30" @default.
• W4311173945 title "Mesenchymal stem cells-derived exosomal miR-653-5p suppresses laryngeal papilloma progression by inhibiting BZW2" @default.
• W4311173945 cites W1977574486 @default.
• W4311173945 cites W1989184473 @default.
• W4311173945 cites W2006868614 @default.
• W4311173945 cites W2042617633 @default.
• W4311173945 cites W2067722913 @default.
• W4311173945 cites W2083843591 @default.
• W4311173945 cites W2098259366 @default.
• W4311173945 cites W2121354606 @default.
• W4311173945 cites W2131690955 @default.
• W4311173945 cites W2137121544 @default.
• W4311173945 cites W2137666501 @default.
• W4311173945 cites W2143253053 @default.
• W4311173945 cites W2162557990 @default.
• W4311173945 cites W2164815002 @default.
• W4311173945 cites W2166623848 @default.
• W4311173945 cites W2346918698 @default.
• W4311173945 cites W2559871461 @default.
• W4311173945 cites W2744758758 @default.
• W4311173945 cites W2761699988 @default.
• W4311173945 cites W2773923191 @default.
• W4311173945 cites W2910940749 @default.
• W4311173945 cites W2913539256 @default.
• W4311173945 cites W2934153299 @default.
• W4311173945 cites W2934427788 @default.
• W4311173945 cites W2938403043 @default.
• W4311173945 cites W2981468141 @default.
• W4311173945 cites W3003330705 @default.
• W4311173945 cites W3034216895 @default.
• W4311173945 cites W3041287956 @default.
• W4311173945 cites W3046668398 @default.
• W4311173945 cites W3085295240 @default.
• W4311173945 cites W3090280250 @default.
• W4311173945 cites W3120194259 @default.
• W4311173945 cites W3165413311 @default.
• W4311173945 cites W3177996799 @default.
• W4311173945 cites W3181402075 @default.
• W4311173945 cites W3182064359 @default.
• W4311173945 cites W3184310928 @default.
• W4311173945 cites W3186378805 @default.
• W4311173945 cites W3189005553 @default.
• W4311173945 cites W82973767 @default.
• W4311173945 doi "https://doi.org/10.1016/j.clinsp.2022.100129" @default.
• W4311173945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36473368" @default.
• W4311173945 hasPublicationYear "2023" @default.
• W4311173945 type Work @default.
• W4311173945 citedByCount "1" @default.
• W4311173945 countsByYear W43111739452023 @default.
• W4311173945 crossrefType "journal-article" @default.
• W4311173945 hasAuthorship W4311173945A5032020402 @default.
• W4311173945 hasAuthorship W4311173945A5039201527 @default.
• W4311173945 hasAuthorship W4311173945A5042704924 @default.
• W4311173945 hasAuthorship W4311173945A5046595612 @default.
• W4311173945 hasAuthorship W4311173945A5046738991 @default.
• W4311173945 hasAuthorship W4311173945A5055455443 @default.
• W4311173945 hasAuthorship W4311173945A5074789712 @default.
• W4311173945 hasBestOaLocation W43111739451 @default.
• W4311173945 hasConcept C104317684 @default.
• W4311173945 hasConcept C127561419 @default.
• W4311173945 hasConcept C145059251 @default.
• W4311173945 hasConcept C185592680 @default.
• W4311173945 hasConcept C190283241 @default.
• W4311173945 hasConcept C198826908 @default.
• W4311173945 hasConcept C20518536 @default.
• W4311173945 hasConcept C2781261824 @default.
• W4311173945 hasConcept C502942594 @default.
• W4311173945 hasConcept C55493867 @default.
• W4311173945 hasConcept C76419328 @default.
• W4311173945 hasConcept C86803240 @default.
• W4311173945 hasConcept C95444343 @default.
• W4311173945 hasConceptScore W4311173945C104317684 @default.
• W4311173945 hasConceptScore W4311173945C127561419 @default.
• W4311173945 hasConceptScore W4311173945C145059251 @default.
• W4311173945 hasConceptScore W4311173945C185592680 @default.
• W4311173945 hasConceptScore W4311173945C190283241 @default.
• W4311173945 hasConceptScore W4311173945C198826908 @default.
• W4311173945 hasConceptScore W4311173945C20518536 @default.
• W4311173945 hasConceptScore W4311173945C2781261824 @default.
• W4311173945 hasConceptScore W4311173945C502942594 @default.
• W4311173945 hasConceptScore W4311173945C55493867 @default.
• W4311173945 hasConceptScore W4311173945C76419328 @default.
• W4311173945 hasConceptScore W4311173945C86803240 @default.
• W4311173945 hasConceptScore W4311173945C95444343 @default.
• W4311173945 hasLocation W43111739451 @default.
• W4311173945 hasLocation W43111739452 @default.
• W4311173945 hasLocation W43111739453 @default.
• W4311173945 hasOpenAccess W4311173945 @default.

• next