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- W4311175954 abstract "This study aimed to evaluate the inflammatory profile as well as the resolution of inflammation in a ligature-induced periodontal inflammation in rats with depletion and/or supraphysiological testosterone replacement.Sixty male rats (Holtzman) were used in the present study. Study groups were created as following: (1) Sham (no testicle removal); (2) Orchiectomy (OCX), 3) OCX + Testosterone (OCX + T); (4) Sham + Ligature (SH + L); (5) OCX+L; and 6) OCX + T + L. The surgeries were performed on day 1, and testosterone was administered weekly since day 1. On day 15, a cotton ligature was placed around the lower first molars and maintained for 15 days. Morphological changes in periodontal tissues were determined by histopathological analysis. Immunohistochemistry (factor VIII) and immunoenzymatic assay were performed to evaluate angiogenesis process and (pro- and anti-) inflammatory markers, respectively.Ligature promoted a marked inflammatory gingival infiltrate and bone loss (P < 0.05). Supraphysiological testosterone treatment increased the percentage of blood vessels, extracellular matrix and fibroblasts in the presence and absence of periodontal inflammation (P < 0.05). A high dose of testosterone increased factor VIII+ blood vessels and IL-10 expression in inflamed gingival tissue, while PGE2, LXA4 and MPO were reduced as a result of supraphysiological testosterone administration (P < 0.05).These results, in our experimental model, suggest that supraphysiological testosterone treatment stimulated gingival tissue repair during ligature-induced periodontitis, and it seems to be related to an anti-inflammatory and pro-resolutive mechanism resulting by the modulatory effect on PGE2 and IL-10 related to an enhanced angiogenesis." @default.
- W4311175954 created "2022-12-24" @default.
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- W4311175954 date "2023-02-01" @default.
- W4311175954 modified "2023-09-27" @default.
- W4311175954 title "Testosterone replacement relieves ligature-induced periodontitis by mitigating inflammation, increasing pro-resolving markers and promoting angiogenesis in rats: A preclinical study" @default.
- W4311175954 cites W1775749144 @default.
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- W4311175954 cites W1848259078 @default.
- W4311175954 cites W1964544797 @default.
- W4311175954 cites W1979866256 @default.
- W4311175954 cites W1989302791 @default.
- W4311175954 cites W1992767581 @default.
- W4311175954 cites W1997313290 @default.
- W4311175954 cites W2007830383 @default.
- W4311175954 cites W2014281089 @default.
- W4311175954 cites W2016720337 @default.
- W4311175954 cites W2019017715 @default.
- W4311175954 cites W2027494625 @default.
- W4311175954 cites W2028667039 @default.
- W4311175954 cites W2036051320 @default.
- W4311175954 cites W2046703464 @default.
- W4311175954 cites W2047869815 @default.
- W4311175954 cites W2050390830 @default.
- W4311175954 cites W2050536724 @default.
- W4311175954 cites W2063938833 @default.
- W4311175954 cites W2064228630 @default.
- W4311175954 cites W2065766649 @default.
- W4311175954 cites W2068754779 @default.
- W4311175954 cites W2074307991 @default.
- W4311175954 cites W2077332962 @default.
- W4311175954 cites W2079174060 @default.
- W4311175954 cites W2079604770 @default.
- W4311175954 cites W2082085040 @default.
- W4311175954 cites W2086033902 @default.
- W4311175954 cites W2098133718 @default.
- W4311175954 cites W2101224501 @default.
- W4311175954 cites W2103010344 @default.
- W4311175954 cites W2105003767 @default.
- W4311175954 cites W2108931019 @default.
- W4311175954 cites W2126844160 @default.
- W4311175954 cites W2131221482 @default.
- W4311175954 cites W2148120568 @default.
- W4311175954 cites W2152052046 @default.
- W4311175954 cites W2162012682 @default.
- W4311175954 cites W2179333912 @default.
- W4311175954 cites W2203857788 @default.
- W4311175954 cites W2338313123 @default.
- W4311175954 cites W2475745356 @default.
- W4311175954 cites W2490699880 @default.
- W4311175954 cites W2521239623 @default.
- W4311175954 cites W2522500216 @default.
- W4311175954 cites W2550145183 @default.
- W4311175954 cites W2589030468 @default.
- W4311175954 cites W2597595800 @default.
- W4311175954 cites W2599306179 @default.
- W4311175954 cites W2607528339 @default.
- W4311175954 cites W2607672964 @default.
- W4311175954 cites W2759229640 @default.
- W4311175954 cites W2789489125 @default.
- W4311175954 cites W2793851045 @default.
- W4311175954 cites W2794093739 @default.
- W4311175954 cites W2796313978 @default.
- W4311175954 cites W2896542867 @default.
- W4311175954 cites W2897722618 @default.
- W4311175954 cites W2964687162 @default.
- W4311175954 cites W2981690694 @default.
- W4311175954 cites W2984719377 @default.
- W4311175954 cites W2996445404 @default.
- W4311175954 cites W3003604034 @default.
- W4311175954 cites W3010987200 @default.
- W4311175954 cites W3023972696 @default.
- W4311175954 cites W3039407063 @default.
- W4311175954 cites W3042209708 @default.
- W4311175954 cites W3046615165 @default.
- W4311175954 cites W4220977529 @default.
- W4311175954 cites W4255289084 @default.
- W4311175954 cites W4285008905 @default.
- W4311175954 cites W4293773505 @default.
- W4311175954 cites W652450657 @default.
- W4311175954 doi "https://doi.org/10.1016/j.archoralbio.2022.105605" @default.
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- W4311175954 hasPublicationYear "2023" @default.
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