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- W4311179667 abstract "Summary Type 1 diabetes-associated single nucleotide polymorphisms are mainly located in non-coding regions of the human genome. Single nucleotide polymorphisms located in long non-coding RNAs may result in the disruption of their secondary structure, affecting their function. Here, we functionally characterized the virus-induced type 1 diabetes-associated lncRNA ARGI (Antiviral Response Gene Inducer). ARGI upregulation in pancreatic β cells leads to the transcriptional activation of antiviral and pro-inflammatory genes. Upon a viral insult, ARGI is upregulated in the nuclei of pancreatic β cells and binds to CTCF to interact with the regulatory regions of IFNβ and interferon-stimulated genes, promoting their transcriptional activation in an allele-specific manner. The presence of the risk allele for type 1 diabetes in ARGI induces an hyperactivation of type I IFN response in β cells, an expression signature that is present in the pancreas of diabetic patients. These data shed light on the molecular mechanisms by which type 1 diabetes-related single nucleotide polymorphisms in long non-coding RNAs influence pathogenesis at the pancreatic β cell level." @default.
- W4311179667 created "2022-12-24" @default.
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- W4311179667 date "2022-12-02" @default.
- W4311179667 modified "2023-09-26" @default.
- W4311179667 title "The type 1 diabetes-associated lncRNA<i>ARGI</i>participates in virus-induced pancreatic β cell inflammation" @default.
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- W4311179667 doi "https://doi.org/10.1101/2022.12.01.518685" @default.
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