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- W4311185418 abstract "Little is known about the molecular mechanisms of ceramide-mediated cellular signaling. We examined the effects of palmitoyl ceramide (C16-ceramide) and stearoyl ceramide (C18-ceramide) on the phase behavior of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) using differential scanning calorimetry (DSC) and small- and wide-angle X-ray scattering (SAXS, WAXS). As previously published, the presence of ceramides increased the lamellar gel-to-lamellar liquid crystalline (Lβ-Lα) phase transition temperature of POPC and POPE and decreased the Lα-to-inverted hexagonal (Lα-HII) phase transition temperature of POPE. Interestingly, despite an ~ 30° difference in the main phase transition temperatures of POPC and POPE, the Lβ-Lα phase transition temperatures were very close between POPC/C18-ceramide and POPE/C18-ceramide and were near physiological temperature. A comparison of the results of C16-ceramide in published and our own results with those of C18-ceramide indicates that increase of the carbon chain length of ceramide from 16 to 18 and/or the small difference of ceramide content in the membrane dramatically change the phase transition temperature of POPC and POPE to near physiological temperature. Our results support the idea that ceramide signaling is mediated by the alteration of lipid phase-dependent partitioning of signaling proteins." @default.
- W4311185418 created "2022-12-24" @default.
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- W4311185418 date "2022-12-02" @default.
- W4311185418 modified "2023-10-10" @default.
- W4311185418 title "Long chain ceramides raise the main phase transition of monounsaturated phospholipids to physiological temperature" @default.
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- W4311185418 doi "https://doi.org/10.1038/s41598-022-25330-y" @default.
- W4311185418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36460753" @default.
- W4311185418 hasPublicationYear "2022" @default.
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