FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311185590> ?p ?o ?g. }

• W4311185590 abstract "Abstract Background Amnestic mild cognitive impairment (aMCI) is often considered a precursor to Alzheimer’s disease (AD) and represents a key therapeutic target for early intervention of AD. However, no treatments have been approved for MCI at present. Our previous pilot study has shown that Kami Guibi-tang (KGT), a traditional herbal prescription widely used in Korean medicine for treating amnesia, might be beneficial for improving general cognitive function of aMCI patients. We will conduct a larger-scale clinical trial to validate the findings of our pilot study and further examine the efficacy and safety of KGT in aMCI. Methods This trial is designed as a randomized, double-blind, placebo-controlled clinical trial. A total of 84 aMCI patients will be recruited and randomized into the treatment and control groups. Participants will be administered either KGT or placebo granules for 24 weeks, with a follow-up period of 12 weeks after the last treatment. Primary outcomes will include changes in cognitive performance assessed using a neuropsychological test battery, called the Seoul Neuropsychological Screening Battery, between the baseline, post-intervention visit, and follow-up visit (24th and 36th week, respectively). Secondary outcomes will involve the rate of progression to AD, changes in neuroimaging signals assessed using structural magnetic resonance imaging (MRI), resting-state functional MRI (rs-fMRI), and task-based fMRI, and changes in blood biomarkers measured by the ratio of plasma amyloid-β 42/40 levels (Aβ42/Aβ40) between the baseline and post-intervention visit (24th week). For safety assessments, blood chemistry tests and electrocardiograms (ECG) will also be performed. Discussion This study aims to provide confirmatory evidence of the effect of the Korean herbal medicine, KGT, on improving cognitive function in patients with aMCI. We will identify the possible mechanisms underlying the effects of KGT using neuroimaging signals and blood biomarkers. Trial registration Korean Clinical Trial Registry ( https://cris.nih.go.kr/cris/search/detailSearch.do/16918; Registration number: KCT0007039; Date of registration: February 24, 2022)." @default.
• W4311185590 created "2022-12-24" @default.
• W4311185590 creator A5020939032 @default.
• W4311185590 creator A5028657950 @default.
• W4311185590 creator A5034061448 @default.
• W4311185590 creator A5034983340 @default.
• W4311185590 creator A5036164849 @default.
• W4311185590 creator A5042114771 @default.
• W4311185590 creator A5044664640 @default.
• W4311185590 creator A5047766546 @default.
• W4311185590 creator A5059077808 @default.
• W4311185590 creator A5082341428 @default.
• W4311185590 creator A5083940893 @default.
• W4311185590 date "2022-12-02" @default.
• W4311185590 modified "2023-10-18" @default.
• W4311185590 title "Effects of Kami Guibi-tang in patients with mild cognitive impairment: study protocol for a phase III, randomized, double-blind, and placebo-controlled trial" @default.
• W4311185590 cites W1847168837 @default.
• W4311185590 cites W1963487177 @default.
• W4311185590 cites W1992720844 @default.
• W4311185590 cites W2006011964 @default.
• W4311185590 cites W2008854521 @default.
• W4311185590 cites W2022850153 @default.
• W4311185590 cites W2052226124 @default.
• W4311185590 cites W2058161128 @default.
• W4311185590 cites W2058828201 @default.
• W4311185590 cites W2068108153 @default.
• W4311185590 cites W2070559120 @default.
• W4311185590 cites W2072537889 @default.
• W4311185590 cites W2076148729 @default.
• W4311185590 cites W2099145543 @default.
• W4311185590 cites W2125630263 @default.
• W4311185590 cites W2148080316 @default.
• W4311185590 cites W2160715919 @default.
• W4311185590 cites W2167311298 @default.
• W4311185590 cites W2414917913 @default.
• W4311185590 cites W2736518852 @default.
• W4311185590 cites W2739958511 @default.
• W4311185590 cites W2785757836 @default.
• W4311185590 cites W2798254777 @default.
• W4311185590 cites W2807908041 @default.
• W4311185590 cites W2900969253 @default.
• W4311185590 cites W3005048617 @default.
• W4311185590 cites W3202816964 @default.
• W4311185590 doi "https://doi.org/10.1186/s12906-022-03805-9" @default.
• W4311185590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36461035" @default.
• W4311185590 hasPublicationYear "2022" @default.
• W4311185590 type Work @default.
• W4311185590 citedByCount "0" @default.
• W4311185590 crossrefType "journal-article" @default.
• W4311185590 hasAuthorship W4311185590A5020939032 @default.
• W4311185590 hasAuthorship W4311185590A5028657950 @default.
• W4311185590 hasAuthorship W4311185590A5034061448 @default.
• W4311185590 hasAuthorship W4311185590A5034983340 @default.
• W4311185590 hasAuthorship W4311185590A5036164849 @default.
• W4311185590 hasAuthorship W4311185590A5042114771 @default.
• W4311185590 hasAuthorship W4311185590A5044664640 @default.
• W4311185590 hasAuthorship W4311185590A5047766546 @default.
• W4311185590 hasAuthorship W4311185590A5059077808 @default.
• W4311185590 hasAuthorship W4311185590A5082341428 @default.
• W4311185590 hasAuthorship W4311185590A5083940893 @default.
• W4311185590 hasBestOaLocation W43111855901 @default.
• W4311185590 hasConcept C118552586 @default.
• W4311185590 hasConcept C126322002 @default.
• W4311185590 hasConcept C126838900 @default.
• W4311185590 hasConcept C14216870 @default.
• W4311185590 hasConcept C142724271 @default.
• W4311185590 hasConcept C143409427 @default.
• W4311185590 hasConcept C168563851 @default.
• W4311185590 hasConcept C169900460 @default.
• W4311185590 hasConcept C204787440 @default.
• W4311185590 hasConcept C27081682 @default.
• W4311185590 hasConcept C535046627 @default.
• W4311185590 hasConcept C58693492 @default.
• W4311185590 hasConcept C71924100 @default.
• W4311185590 hasConceptScore W4311185590C118552586 @default.
• W4311185590 hasConceptScore W4311185590C126322002 @default.
• W4311185590 hasConceptScore W4311185590C126838900 @default.
• W4311185590 hasConceptScore W4311185590C14216870 @default.
• W4311185590 hasConceptScore W4311185590C142724271 @default.
• W4311185590 hasConceptScore W4311185590C143409427 @default.
• W4311185590 hasConceptScore W4311185590C168563851 @default.
• W4311185590 hasConceptScore W4311185590C169900460 @default.
• W4311185590 hasConceptScore W4311185590C204787440 @default.
• W4311185590 hasConceptScore W4311185590C27081682 @default.
• W4311185590 hasConceptScore W4311185590C535046627 @default.
• W4311185590 hasConceptScore W4311185590C58693492 @default.
• W4311185590 hasConceptScore W4311185590C71924100 @default.
• W4311185590 hasFunder F4320322107 @default.
• W4311185590 hasIssue "1" @default.
• W4311185590 hasLocation W43111855901 @default.
• W4311185590 hasLocation W43111855902 @default.
• W4311185590 hasLocation W43111855903 @default.
• W4311185590 hasOpenAccess W4311185590 @default.
• W4311185590 hasPrimaryLocation W43111855901 @default.
• W4311185590 hasRelatedWork W2056637972 @default.
• W4311185590 hasRelatedWork W2069084234 @default.
• W4311185590 hasRelatedWork W2093041092 @default.
• W4311185590 hasRelatedWork W2397490793 @default.
• W4311185590 hasRelatedWork W2781541284 @default.
• W4311185590 hasRelatedWork W3159250744 @default.

• next