FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311185813> ?p ?o ?g. }

• W4311185813 abstract "Humans have been challenged by infectious diseases for all of their recorded history, and are continually being affected even today. Next-generation sequencing (NGS) has enabled identification of, i) culture independent microbes, ii) emerging disease-causing pathogens, and iii) understanding of the genome architecture. This, in turn, has highlighted that pathogen/s are not a monolith, and thereby allowing for the differentiation of the wide-ranging disease symptoms, albeit infected by a primary pathogen. The conventional ‘one disease - one pathogen’ paradigm has been positively revisited by considering limited yet important evidence of the co-presence of multiple transcriptionally active microbes (TAMs), potential pathogens, in various infectious diseases, including the COVID-19 pandemic. The ubiquitous microbiota presence inside humans gives reason to hypothesize that the microbiome, especially TAMs, contributes to disease etiology. Herein, we discuss current evidence and inferences on the co-infecting microbes particularly in the diseases caused by the RNA viruses - Influenza, Dengue, and the SARS-CoV-2. We have highlighted that the specific alterations in the microbial taxonomic abundances (dysbiosis) is functionally connected to the exposure of primary infecting pathogen/s. The microbial presence is intertwined with the differential host immune response modulating differential disease trajectories. The microbiota-host interactions have been shown to modulate the host immune responses to Influenza and SARS-CoV-2 infection, wherein the active commensal microbes are involved in the generation of virus-specific CD4 and CD8 T-cells following the influenza virus infection. Furthermore, COVID-19 dysbiosis causes an increase in inflammatory cytokines such as IL-6, TNF-α, and IL-1β, which might be one of the important predisposing factors for severe infection. Through this article, we aim to provide a comprehensive view of functional microbiomes that can have a significant regulatory impact on predicting disease severity (mild, moderate and severe), as well as clinical outcome (survival and mortality). This can offer fresh perspectives on the novel microbial biomarkers for stratifying patients for severe disease symptoms, disease prevention and augmenting treatment regimens." @default.
• W4311185813 created "2022-12-24" @default.
• W4311185813 creator A5029932093 @default.
• W4311185813 creator A5045353438 @default.
• W4311185813 date "2022-12-02" @default.
• W4311185813 modified "2023-09-30" @default.
• W4311185813 title "Viral infectious diseases severity: co-presence of transcriptionally active microbes (TAMs) can play an integral role for disease severity" @default.
• W4311185813 cites W136988059 @default.
• W4311185813 cites W1533085868 @default.
• W4311185813 cites W1604767220 @default.
• W4311185813 cites W1918510262 @default.
• W4311185813 cites W1963515220 @default.
• W4311185813 cites W1965105151 @default.
• W4311185813 cites W1970472465 @default.
• W4311185813 cites W1986597274 @default.
• W4311185813 cites W1988457839 @default.
• W4311185813 cites W1988759012 @default.
• W4311185813 cites W1991039591 @default.
• W4311185813 cites W1998653357 @default.
• W4311185813 cites W1999820650 @default.
• W4311185813 cites W2023630186 @default.
• W4311185813 cites W2027061295 @default.
• W4311185813 cites W2028066970 @default.
• W4311185813 cites W2033327108 @default.
• W4311185813 cites W2038892862 @default.
• W4311185813 cites W2043287899 @default.
• W4311185813 cites W2043996818 @default.
• W4311185813 cites W2052683965 @default.
• W4311185813 cites W2053341712 @default.
• W4311185813 cites W2058092689 @default.
• W4311185813 cites W2060185417 @default.
• W4311185813 cites W2081653606 @default.
• W4311185813 cites W2086251952 @default.
• W4311185813 cites W2092305725 @default.
• W4311185813 cites W2098084836 @default.
• W4311185813 cites W2108100953 @default.
• W4311185813 cites W2108978157 @default.
• W4311185813 cites W2113810254 @default.
• W4311185813 cites W2119611042 @default.
• W4311185813 cites W2121500154 @default.
• W4311185813 cites W2122007620 @default.
• W4311185813 cites W2124557952 @default.
• W4311185813 cites W2125826054 @default.
• W4311185813 cites W2127612599 @default.
• W4311185813 cites W2131186249 @default.
• W4311185813 cites W2136221378 @default.
• W4311185813 cites W2142747186 @default.
• W4311185813 cites W2156591001 @default.
• W4311185813 cites W2156868373 @default.
• W4311185813 cites W2161271569 @default.
• W4311185813 cites W2161352357 @default.
• W4311185813 cites W2161868263 @default.
• W4311185813 cites W2167511301 @default.
• W4311185813 cites W2167944937 @default.
• W4311185813 cites W2168805867 @default.
• W4311185813 cites W2170850530 @default.
• W4311185813 cites W2172861511 @default.
• W4311185813 cites W2254642444 @default.
• W4311185813 cites W2261043905 @default.
• W4311185813 cites W2291472159 @default.
• W4311185813 cites W2291675941 @default.
• W4311185813 cites W2402456610 @default.
• W4311185813 cites W2504671095 @default.
• W4311185813 cites W2508794604 @default.
• W4311185813 cites W2520938889 @default.
• W4311185813 cites W2521607002 @default.
• W4311185813 cites W2523421524 @default.
• W4311185813 cites W2558408679 @default.
• W4311185813 cites W2560668770 @default.
• W4311185813 cites W2566188242 @default.
• W4311185813 cites W2577806521 @default.
• W4311185813 cites W2579549256 @default.
• W4311185813 cites W2582447685 @default.
• W4311185813 cites W2603148361 @default.
• W4311185813 cites W2618209467 @default.
• W4311185813 cites W2627092521 @default.
• W4311185813 cites W2653295461 @default.
• W4311185813 cites W2740951628 @default.
• W4311185813 cites W2741622086 @default.
• W4311185813 cites W2753339320 @default.
• W4311185813 cites W2769653876 @default.
• W4311185813 cites W2775569101 @default.
• W4311185813 cites W2790466811 @default.
• W4311185813 cites W2791709730 @default.
• W4311185813 cites W2807176368 @default.
• W4311185813 cites W2895261413 @default.
• W4311185813 cites W2898904131 @default.
• W4311185813 cites W2901511714 @default.
• W4311185813 cites W2904662596 @default.
• W4311185813 cites W2921966151 @default.
• W4311185813 cites W2926238016 @default.
• W4311185813 cites W2941532136 @default.
• W4311185813 cites W2947038645 @default.
• W4311185813 cites W2952094509 @default.
• W4311185813 cites W2983840232 @default.
• W4311185813 cites W3000641988 @default.
• W4311185813 cites W3009912996 @default.
• W4311185813 cites W3010071328 @default.
• W4311185813 cites W3013959692 @default.
• W4311185813 cites W3017108443 @default.

• next