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• W4311189669 abstract "ABSTRACT Breakthrough infections by SARS-CoV-2 variants pose a global challenge to pandemic control, and the development of more effective vaccines of broadspectrum protection is needed. In this study, we constructed pVAX1-based plasmids encoding heterodimeric receptor-binding domain (RBD) chimera of SARS-CoV and SARS-CoV-2 Omicron BA.1 (RBD SARS/BA1 ), SARS-CoV and SARS-CoV-2 Beta (RBD SARS/Beta ), or Omicron BA.1 and Beta (RBD BA1/Beta ) in secreted form. When i.m. injected in mice, RBD SARS/BA1 and RBD SARS/Beta encoding plasmids (pAD1002 and pAD131, respectively) were by far more immunogenic than RBD BA1/Beta plasmid (pAD1003). Dissolvable microneedle array patches (MAP) laden with these DNA plasmids were fabricated. All 3 resulting MAP-based vaccine candidates, namely MAP-1002, MAP1003 and MAP-131, were comparable to i.m. inoculated plasmids with electroporation assistance in eliciting strong and durable IgG responses in BALB/c and C57BL/6 mice as well as rabbits, while MAP-1002 was comparatively the most immunogenic. More importantly, MAP-1002 significantly outperformed inactivated SARS-CoV-2 virus vaccine in inducing RBD-specific IFN-γ + T cells. Moreover, MAP-1002 antisera effectively neutralized pseudoviruses displaying spike proteins of SARS-CoV, prototype SARS-CoV-2 or Beta, Delta, Omicron BA1, BA2 and BA4/5 variants. Collectively, MAP-based DNA constructs encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, as represented by MAP-1002, are potential COVID-19 vaccine candidates worthy further translational study." @default.
• W4311189669 created "2022-12-24" @default.
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• W4311189669 date "2022-12-02" @default.
• W4311189669 modified "2023-09-28" @default.
• W4311189669 title "Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants" @default.
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• W4311189669 doi "https://doi.org/10.1101/2022.12.01.518127" @default.
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