Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311192238> ?p ?o ?g. }
- W4311192238 endingPage "3113" @default.
- W4311192238 startingPage "3113" @default.
- W4311192238 abstract "Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as brain fog, fatigue and clotting problems. Explanations for long COVID include immune imbalance, incomplete viral clearance and potentially, mitochondrial dysfunction. As conditions with sub-optimal mitochondrial function are associated with initial severity of the disease, their prior health could be key in resistance to long COVID and recovery. The SARs virus redirects host metabolism towards replication; in response, the host can metabolically react to control the virus. Resolution is normally achieved after viral clearance as the initial stress activates a hormetic negative feedback mechanism. It is therefore possible that, in some individuals with prior sub-optimal mitochondrial function, the virus can tip the host into a chronic inflammatory cycle. This might explain the main symptoms, including platelet dysfunction. Long COVID could thus be described as a virally induced chronic and self-perpetuating metabolically imbalanced non-resolving state characterised by mitochondrial dysfunction, where reactive oxygen species continually drive inflammation and a shift towards glycolysis. This would suggest that a sufferer's metabolism needs to be tipped back using a stimulus, such as physical activity, calorie restriction, or chemical compounds that mimic these by enhancing mitochondrial function, perhaps in combination with inhibitors that quell the inflammatory response." @default.
- W4311192238 created "2022-12-24" @default.
- W4311192238 creator A5005307132 @default.
- W4311192238 creator A5021196507 @default.
- W4311192238 creator A5057380504 @default.
- W4311192238 creator A5089627681 @default.
- W4311192238 date "2022-12-02" @default.
- W4311192238 modified "2023-10-13" @default.
- W4311192238 title "Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems" @default.
- W4311192238 cites W1738348680 @default.
- W4311192238 cites W1876544915 @default.
- W4311192238 cites W1955171351 @default.
- W4311192238 cites W1988713919 @default.
- W4311192238 cites W1997572777 @default.
- W4311192238 cites W1997844483 @default.
- W4311192238 cites W1999754980 @default.
- W4311192238 cites W2000205368 @default.
- W4311192238 cites W2001986473 @default.
- W4311192238 cites W2003849432 @default.
- W4311192238 cites W2004129180 @default.
- W4311192238 cites W2012173045 @default.
- W4311192238 cites W2014716069 @default.
- W4311192238 cites W2017280976 @default.
- W4311192238 cites W2019453676 @default.
- W4311192238 cites W2032206556 @default.
- W4311192238 cites W2033448006 @default.
- W4311192238 cites W2036229829 @default.
- W4311192238 cites W2053022803 @default.
- W4311192238 cites W2058881502 @default.
- W4311192238 cites W2070333365 @default.
- W4311192238 cites W2070979531 @default.
- W4311192238 cites W2072319820 @default.
- W4311192238 cites W2080274549 @default.
- W4311192238 cites W2089090200 @default.
- W4311192238 cites W2090005130 @default.
- W4311192238 cites W2091959680 @default.
- W4311192238 cites W2101803219 @default.
- W4311192238 cites W2104712904 @default.
- W4311192238 cites W2112141400 @default.
- W4311192238 cites W2115950845 @default.
- W4311192238 cites W2130879922 @default.
- W4311192238 cites W2133435829 @default.
- W4311192238 cites W2143516906 @default.
- W4311192238 cites W2147971715 @default.
- W4311192238 cites W2156746071 @default.
- W4311192238 cites W2166847826 @default.
- W4311192238 cites W2171224838 @default.
- W4311192238 cites W2294704562 @default.
- W4311192238 cites W2461347934 @default.
- W4311192238 cites W2540250076 @default.
- W4311192238 cites W2597215499 @default.
- W4311192238 cites W2597895499 @default.
- W4311192238 cites W2601394082 @default.
- W4311192238 cites W2607038632 @default.
- W4311192238 cites W2610529302 @default.
- W4311192238 cites W2615482484 @default.
- W4311192238 cites W2625087901 @default.
- W4311192238 cites W2763705386 @default.
- W4311192238 cites W2766330091 @default.
- W4311192238 cites W2773560724 @default.
- W4311192238 cites W2783359722 @default.
- W4311192238 cites W2789917045 @default.
- W4311192238 cites W2804802591 @default.
- W4311192238 cites W2807339320 @default.
- W4311192238 cites W2890423459 @default.
- W4311192238 cites W2890600951 @default.
- W4311192238 cites W2893841769 @default.
- W4311192238 cites W2894565780 @default.
- W4311192238 cites W2897213700 @default.
- W4311192238 cites W2898761605 @default.
- W4311192238 cites W2914218700 @default.
- W4311192238 cites W2914634060 @default.
- W4311192238 cites W2927901935 @default.
- W4311192238 cites W2944379014 @default.
- W4311192238 cites W2949196134 @default.
- W4311192238 cites W2955765394 @default.
- W4311192238 cites W2981345296 @default.
- W4311192238 cites W2982399071 @default.
- W4311192238 cites W2982479733 @default.
- W4311192238 cites W2985749257 @default.
- W4311192238 cites W2990090288 @default.
- W4311192238 cites W2997046468 @default.
- W4311192238 cites W2997638985 @default.
- W4311192238 cites W2997790736 @default.
- W4311192238 cites W2999837121 @default.
- W4311192238 cites W3002410708 @default.
- W4311192238 cites W3005108422 @default.
- W4311192238 cites W3005794975 @default.
- W4311192238 cites W3009804001 @default.
- W4311192238 cites W3012073330 @default.
- W4311192238 cites W3026028702 @default.
- W4311192238 cites W3027187955 @default.
- W4311192238 cites W3028964082 @default.
- W4311192238 cites W3031175788 @default.
- W4311192238 cites W3031542208 @default.
- W4311192238 cites W3033084077 @default.
- W4311192238 cites W3033090821 @default.
- W4311192238 cites W3033126715 @default.