FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311201306> ?p ?o ?g. }

• W4311201306 endingPage "18" @default.
• W4311201306 startingPage "12" @default.
• W4311201306 abstract "BackgroundEicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been suggested to play roles in various diseases, yet there is little data on their changes in patients with non-small-cell lung cancer (NSCLC). A simple LC-MS/MS method for EPA and DHA determination is critical to exploring EPA and DHA level changes in NSCLC patients.Methods25 µL of serum was mixed with 25 µL of internal standard working solution, and then 450 µL of acetonitrile for protein precipitation. After vortex and centrifugation, the supernatant was directly used for LC-MS/MS analysis. The method was well validated with linearity, precision, recovery, and matrix effect. The concentrations of EPA and DHA in serum samples from 211 NSCLC patients and 227 healthy controls were determined by this LC-MS/MS method.ResultsGood separation and reliable quantification of EPA and DHA in serum samples were achieved by our method. Compared with healthy controls, serum EPA and DHA were significantly reduced in both adenocarcinoma and squamous cell carcinoma patients. The concentrations of EPA and DHA showed a progressive decrease in healthy controls, early- and advanced-stage NSCLC patients.ConclusionsThis study identified significant reductions in serum EPA and DHA in NSCLC patients through the development of an LC-MS/MS method." @default.
• W4311201306 created "2022-12-24" @default.
• W4311201306 creator A5010407115 @default.
• W4311201306 creator A5011690119 @default.
• W4311201306 creator A5020286464 @default.
• W4311201306 creator A5029667848 @default.
• W4311201306 creator A5069043710 @default.
• W4311201306 creator A5072550702 @default.
• W4311201306 creator A5074871313 @default.
• W4311201306 creator A5082905009 @default.
• W4311201306 date "2023-01-01" @default.
• W4311201306 modified "2023-10-16" @default.
• W4311201306 title "Reduced levels of serum EPA and DHA identified in patients with non-small-cell lung cancer using a new rapid validated LC-MS/MS method" @default.
• W4311201306 cites W1784896684 @default.
• W4311201306 cites W1936767008 @default.
• W4311201306 cites W1965037168 @default.
• W4311201306 cites W1975173686 @default.
• W4311201306 cites W1984900076 @default.
• W4311201306 cites W1996399542 @default.
• W4311201306 cites W2008218878 @default.
• W4311201306 cites W2021500692 @default.
• W4311201306 cites W2044925866 @default.
• W4311201306 cites W2062906894 @default.
• W4311201306 cites W2097421933 @default.
• W4311201306 cites W2100649229 @default.
• W4311201306 cites W2101974947 @default.
• W4311201306 cites W2102799199 @default.
• W4311201306 cites W2122430630 @default.
• W4311201306 cites W2128572607 @default.
• W4311201306 cites W2128818259 @default.
• W4311201306 cites W2142849241 @default.
• W4311201306 cites W2147056998 @default.
• W4311201306 cites W2155632205 @default.
• W4311201306 cites W2253276860 @default.
• W4311201306 cites W2527370332 @default.
• W4311201306 cites W2610366558 @default.
• W4311201306 cites W2772102301 @default.
• W4311201306 cites W2884937827 @default.
• W4311201306 cites W2910204771 @default.
• W4311201306 cites W2910421614 @default.
• W4311201306 cites W2942242168 @default.
• W4311201306 cites W2967262441 @default.
• W4311201306 cites W2978449399 @default.
• W4311201306 cites W2990042485 @default.
• W4311201306 cites W3025880719 @default.
• W4311201306 cites W3030380615 @default.
• W4311201306 cites W3195224555 @default.
• W4311201306 cites W4205733825 @default.
• W4311201306 cites W4281617357 @default.
• W4311201306 doi "https://doi.org/10.1016/j.slasd.2022.11.004" @default.
• W4311201306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36464159" @default.
• W4311201306 hasPublicationYear "2023" @default.
• W4311201306 type Work @default.
• W4311201306 citedByCount "0" @default.
• W4311201306 crossrefType "journal-article" @default.
• W4311201306 hasAuthorship W4311201306A5010407115 @default.
• W4311201306 hasAuthorship W4311201306A5011690119 @default.
• W4311201306 hasAuthorship W4311201306A5020286464 @default.
• W4311201306 hasAuthorship W4311201306A5029667848 @default.
• W4311201306 hasAuthorship W4311201306A5069043710 @default.
• W4311201306 hasAuthorship W4311201306A5072550702 @default.
• W4311201306 hasAuthorship W4311201306A5074871313 @default.
• W4311201306 hasAuthorship W4311201306A5082905009 @default.
• W4311201306 hasBestOaLocation W43112013061 @default.
• W4311201306 hasConcept C121608353 @default.
• W4311201306 hasConcept C126322002 @default.
• W4311201306 hasConcept C185592680 @default.
• W4311201306 hasConcept C19038510 @default.
• W4311201306 hasConcept C2776256026 @default.
• W4311201306 hasConcept C2777171753 @default.
• W4311201306 hasConcept C2781182431 @default.
• W4311201306 hasConcept C43617362 @default.
• W4311201306 hasConcept C543025807 @default.
• W4311201306 hasConcept C55493867 @default.
• W4311201306 hasConcept C71924100 @default.
• W4311201306 hasConceptScore W4311201306C121608353 @default.
• W4311201306 hasConceptScore W4311201306C126322002 @default.
• W4311201306 hasConceptScore W4311201306C185592680 @default.
• W4311201306 hasConceptScore W4311201306C19038510 @default.
• W4311201306 hasConceptScore W4311201306C2776256026 @default.
• W4311201306 hasConceptScore W4311201306C2777171753 @default.
• W4311201306 hasConceptScore W4311201306C2781182431 @default.
• W4311201306 hasConceptScore W4311201306C43617362 @default.
• W4311201306 hasConceptScore W4311201306C543025807 @default.
• W4311201306 hasConceptScore W4311201306C55493867 @default.
• W4311201306 hasConceptScore W4311201306C71924100 @default.
• W4311201306 hasFunder F4320321001 @default.
• W4311201306 hasFunder F4320335777 @default.
• W4311201306 hasIssue "1" @default.
• W4311201306 hasLocation W43112013061 @default.
• W4311201306 hasLocation W43112013062 @default.
• W4311201306 hasOpenAccess W4311201306 @default.
• W4311201306 hasPrimaryLocation W43112013061 @default.
• W4311201306 hasRelatedWork W1984929305 @default.
• W4311201306 hasRelatedWork W1990478119 @default.
• W4311201306 hasRelatedWork W2110419883 @default.
• W4311201306 hasRelatedWork W2168330912 @default.
• W4311201306 hasRelatedWork W2735678088 @default.

• next