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- W4311205352 endingPage "259" @default.
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- W4311205352 abstract "The use of psychostimulant drugs can modify brain function by inducing changes in the reward system, mainly due to alterations in dopaminergic and glutamatergic transmissions in the mesocorticolimbic pathway. However, the etiopathogenesis of addiction is a much more complex process. Previous data have suggested that microglia and other immune cells are involved in events associated with neuroplasticity and memory, which are phenomena that also occur in addiction. Nevertheless, how dependent is the development of addiction on the activity of these cells? Although the mechanisms are not known, some pathways may be involved. Recent data have shown psychoactive substances may act directly on immune cells, alter their functions and induce various inflammatory mediators that modulate synaptic activity. These could, in turn, be involved in the pathological alterations that occur in substance use disorder. Here, we extensively review the studies demonstrating how cocaine and amphetamines modulate microglial number, morphology, and function. We also describe the effect of these substances in the production of inflammatory mediators and a possible involvement of some molecular signaling pathways, such as the toll-like receptor 4. Although the literature in this field is scarce, this review compiles the knowledge on the neuroimmune axis that is involved in the pathogenesis of addiction, and suggests some pharmacological targets for the development of pharmacotherapy." @default.
- W4311205352 created "2022-12-24" @default.
- W4311205352 creator A5000044468 @default.
- W4311205352 creator A5006709429 @default.
- W4311205352 creator A5008899169 @default.
- W4311205352 creator A5019080515 @default.
- W4311205352 creator A5064044893 @default.
- W4311205352 creator A5073191722 @default.
- W4311205352 date "2023-02-01" @default.
- W4311205352 modified "2023-10-12" @default.
- W4311205352 title "Role of Microglia in Psychostimulant Addiction" @default.
- W4311205352 cites W1066252868 @default.
- W4311205352 cites W1073627852 @default.
- W4311205352 cites W1421120328 @default.
- W4311205352 cites W1430806458 @default.
- W4311205352 cites W1495230960 @default.
- W4311205352 cites W1496677669 @default.
- W4311205352 cites W1500591297 @default.
- W4311205352 cites W1542136448 @default.
- W4311205352 cites W1562529961 @default.
- W4311205352 cites W1675980378 @default.
- W4311205352 cites W1791708082 @default.
- W4311205352 cites W1813031470 @default.
- W4311205352 cites W1827337539 @default.
- W4311205352 cites W1852882672 @default.
- W4311205352 cites W1909001249 @default.
- W4311205352 cites W1960047863 @default.
- W4311205352 cites W1962727914 @default.
- W4311205352 cites W1965542850 @default.
- W4311205352 cites W1966207206 @default.
- W4311205352 cites W1967031106 @default.
- W4311205352 cites W1969367143 @default.
- W4311205352 cites W1973216215 @default.
- W4311205352 cites W1974623546 @default.
- W4311205352 cites W1975177900 @default.
- W4311205352 cites W1976395395 @default.
- W4311205352 cites W1976764279 @default.
- W4311205352 cites W1977764201 @default.
- W4311205352 cites W1978026086 @default.
- W4311205352 cites W1978521888 @default.
- W4311205352 cites W1979323961 @default.
- W4311205352 cites W1981857717 @default.
- W4311205352 cites W1982644516 @default.
- W4311205352 cites W1985050594 @default.
- W4311205352 cites W1988938316 @default.
- W4311205352 cites W1990530091 @default.
- W4311205352 cites W1991141166 @default.
- W4311205352 cites W1991391691 @default.
- W4311205352 cites W1992533819 @default.
- W4311205352 cites W1993869122 @default.
- W4311205352 cites W1994416984 @default.
- W4311205352 cites W1997962806 @default.
- W4311205352 cites W1998228366 @default.
- W4311205352 cites W1999359671 @default.
- W4311205352 cites W1999677795 @default.
- W4311205352 cites W2000253977 @default.
- W4311205352 cites W2004955095 @default.
- W4311205352 cites W2007383758 @default.
- W4311205352 cites W2008584595 @default.
- W4311205352 cites W2012026469 @default.
- W4311205352 cites W2015266566 @default.
- W4311205352 cites W2016031767 @default.
- W4311205352 cites W2017453007 @default.
- W4311205352 cites W2017483097 @default.
- W4311205352 cites W2017535091 @default.
- W4311205352 cites W2020708538 @default.
- W4311205352 cites W2020713586 @default.
- W4311205352 cites W2021440104 @default.
- W4311205352 cites W2021573775 @default.
- W4311205352 cites W2021635895 @default.
- W4311205352 cites W2022677793 @default.
- W4311205352 cites W2022861863 @default.
- W4311205352 cites W2024331662 @default.
- W4311205352 cites W2025188861 @default.
- W4311205352 cites W2025655040 @default.
- W4311205352 cites W2025921501 @default.
- W4311205352 cites W2033617297 @default.
- W4311205352 cites W2034146948 @default.
- W4311205352 cites W2034840064 @default.
- W4311205352 cites W2035557202 @default.
- W4311205352 cites W2036139330 @default.
- W4311205352 cites W2036629661 @default.
- W4311205352 cites W2037074024 @default.
- W4311205352 cites W2039976686 @default.
- W4311205352 cites W2040610233 @default.
- W4311205352 cites W2042654110 @default.
- W4311205352 cites W2043390267 @default.
- W4311205352 cites W2043851674 @default.
- W4311205352 cites W2044459389 @default.
- W4311205352 cites W2047310207 @default.
- W4311205352 cites W2047660382 @default.
- W4311205352 cites W2049567972 @default.
- W4311205352 cites W2050476288 @default.
- W4311205352 cites W2050909118 @default.
- W4311205352 cites W2051352828 @default.
- W4311205352 cites W2052968752 @default.
- W4311205352 cites W2054657132 @default.
- W4311205352 cites W2055471006 @default.