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• W4311244265 abstract "The nanoparticles (NPs) of noble metals have emerged as biocompatible and site-specific drug delivery vehicles which reduce the undesired site effects and guard against accumulating toxicity. Herein, the drug delivery suitability of gold and silver nanoparticles is focused, owing to their enhanced use and multiple cell line compatibilities. The Au (atomic number 79) is placed exactly below Ag (atomic no. 47) in the 11th group of the periodic table, causing an easier Ag+ generation than Au+, having its valence electron much farther (in 6s subshell), exhibiting higher chemical stability. With such chemical interaction potentials, the Au is better suited as a capping and diagnostic agent, while the Ag aids in toxicity modulation within the tumor cells. The crux lies in transporting the maximum extent of delivered drugs to the needed location via guarding (stealth delivery) against a possible degradation by the physiological enzymes. Active and passive drug deliveries are the major mechanisms operational with NPs, with the former aimed at a direct approach to tumor cells, while the latter operates via drifting the physicochemical barriers in the tumor vicinity. The distinctive aspects conferred by the nanoscale attributes comprise enhanced surface area and facilitate high drug loading ability, ease of functionalization for targeted activities, and easy-to-follow robust bottom-up preparation methods. This chapter sheds light on the various Au and Ag NPs synthesis methods, their drug delivery attributes, a discussion of recent attempts toward lung and breast cancer treatment, and the cautionary aspects about the random toxicity of NPs." @default.
• W4311244265 created "2022-12-25" @default.
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• W4311244265 date "2022-12-14" @default.
• W4311244265 modified "2023-10-12" @default.
• W4311244265 title "Emerging Drug Delivery Potential of Gold and Silver Nanoparticles to Lung and Breast Cancers" @default.
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• W4311244265 doi "https://doi.org/10.1007/978-981-19-1731-8_21-1" @default.
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