Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311279323> ?p ?o ?g. }
- W4311279323 endingPage "658" @default.
- W4311279323 startingPage "646" @default.
- W4311279323 abstract "Central melanocortin 4 receptor (MC4R) has been reported to induce anhedonia via eliciting dysfunction of excitatory synapses. It is evident that metabolic signals are closely related to chronic stress-induced depression. Here, we investigated that a neural circuit is involved in melanocortin signaling contributing to susceptibility to stress.Chronic social defeat stress (CSDS) was used to develop depressive-like behavior. Electrophysiologic and chemogenetic approaches were performed to evaluate the role of paraventricular thalamus (PVT) glutamatergic to nucleus accumbens shell (NAcsh) circuit in stress susceptibility. Pharmacological and genetic manipulations were applied to investigate the molecular mechanisms of melanocortin signaling in the circuit.CSDS increases the excitatory neurotransmission in NAcsh through MC4R signaling. The enhanced excitatory synaptic input in NAcsh is projected from PVT glutamatergic neurons. Moreover, chemogenetic manipulation of PVTGlu -NAcsh projection mediates the susceptibility to stress, which is dependent on MC4R signaling. Overall, these results reveal that the strengthened excitatory neurotransmission in NAcsh originates from PVT glutamatergic neurons, facilitating the susceptibility to stress through melanocortin signaling.Our results make a strong case for harnessing a thalamic circuit to reorganize excitatory synaptic transmission in relieving stress susceptibility and provide insights gained on metabolic underpinnings of protection against stress-induced depressive-like behavior." @default.
- W4311279323 created "2022-12-25" @default.
- W4311279323 creator A5028468227 @default.
- W4311279323 creator A5031734082 @default.
- W4311279323 creator A5033616597 @default.
- W4311279323 creator A5035467773 @default.
- W4311279323 creator A5043043326 @default.
- W4311279323 creator A5065863767 @default.
- W4311279323 creator A5070584261 @default.
- W4311279323 creator A5071616764 @default.
- W4311279323 date "2022-12-12" @default.
- W4311279323 modified "2023-10-15" @default.
- W4311279323 title "A thalamic circuit facilitates stress susceptibility via melanocortin 4 receptor‐mediated activation of nucleus accumbens shell" @default.
- W4311279323 cites W1488596761 @default.
- W4311279323 cites W1958676502 @default.
- W4311279323 cites W1972778574 @default.
- W4311279323 cites W1977593923 @default.
- W4311279323 cites W1991400215 @default.
- W4311279323 cites W2000139014 @default.
- W4311279323 cites W2003982930 @default.
- W4311279323 cites W2020640680 @default.
- W4311279323 cites W2022082745 @default.
- W4311279323 cites W2023679577 @default.
- W4311279323 cites W2031830498 @default.
- W4311279323 cites W2032471499 @default.
- W4311279323 cites W2044655068 @default.
- W4311279323 cites W2045713348 @default.
- W4311279323 cites W2048236085 @default.
- W4311279323 cites W2058073897 @default.
- W4311279323 cites W2062865803 @default.
- W4311279323 cites W2067273260 @default.
- W4311279323 cites W2067639934 @default.
- W4311279323 cites W2072531628 @default.
- W4311279323 cites W2088861514 @default.
- W4311279323 cites W2098181391 @default.
- W4311279323 cites W2106623141 @default.
- W4311279323 cites W2130557233 @default.
- W4311279323 cites W2141609201 @default.
- W4311279323 cites W2142066344 @default.
- W4311279323 cites W2195401308 @default.
- W4311279323 cites W2270599390 @default.
- W4311279323 cites W2409034938 @default.
- W4311279323 cites W2409299128 @default.
- W4311279323 cites W2469794950 @default.
- W4311279323 cites W2520064463 @default.
- W4311279323 cites W2605741546 @default.
- W4311279323 cites W2616069238 @default.
- W4311279323 cites W2755167598 @default.
- W4311279323 cites W2767440265 @default.
- W4311279323 cites W2767512192 @default.
- W4311279323 cites W2789910513 @default.
- W4311279323 cites W2803951049 @default.
- W4311279323 cites W2898537644 @default.
- W4311279323 cites W2908611182 @default.
- W4311279323 cites W2909810226 @default.
- W4311279323 cites W2912841818 @default.
- W4311279323 cites W2922369336 @default.
- W4311279323 cites W2951101553 @default.
- W4311279323 cites W2971724322 @default.
- W4311279323 cites W2973855416 @default.
- W4311279323 cites W3000308852 @default.
- W4311279323 cites W3013047070 @default.
- W4311279323 cites W3026363162 @default.
- W4311279323 cites W3047879827 @default.
- W4311279323 cites W3082986453 @default.
- W4311279323 cites W3084528503 @default.
- W4311279323 cites W3086165694 @default.
- W4311279323 cites W3094653702 @default.
- W4311279323 cites W3115979991 @default.
- W4311279323 cites W3153406603 @default.
- W4311279323 cites W3159367410 @default.
- W4311279323 cites W3161929947 @default.
- W4311279323 cites W3164190486 @default.
- W4311279323 cites W3171015631 @default.
- W4311279323 cites W3194089406 @default.
- W4311279323 cites W3196234495 @default.
- W4311279323 cites W4238754411 @default.
- W4311279323 cites W4311279323 @default.
- W4311279323 cites W585546046 @default.
- W4311279323 doi "https://doi.org/10.1111/cns.14046" @default.
- W4311279323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36510669" @default.
- W4311279323 hasPublicationYear "2022" @default.
- W4311279323 type Work @default.
- W4311279323 citedByCount "1" @default.
- W4311279323 countsByYear W43112793232022 @default.
- W4311279323 crossrefType "journal-article" @default.
- W4311279323 hasAuthorship W4311279323A5028468227 @default.
- W4311279323 hasAuthorship W4311279323A5031734082 @default.
- W4311279323 hasAuthorship W4311279323A5033616597 @default.
- W4311279323 hasAuthorship W4311279323A5035467773 @default.
- W4311279323 hasAuthorship W4311279323A5043043326 @default.
- W4311279323 hasAuthorship W4311279323A5065863767 @default.
- W4311279323 hasAuthorship W4311279323A5070584261 @default.
- W4311279323 hasAuthorship W4311279323A5071616764 @default.
- W4311279323 hasBestOaLocation W43112793232 @default.
- W4311279323 hasConcept C112592302 @default.
- W4311279323 hasConcept C169760540 @default.
- W4311279323 hasConcept C170493617 @default.