FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311282580> ?p ?o ?g. }

• W4311282580 abstract "Circular RNAs (circRNAs) are reverse-spliced and covalently closed RNAs. Their interactions with RNA-binding proteins (RBPs) have multiple effects on the progress of many diseases. Some computational methods are proposed to identify RBP binding sites on circRNAs but suffer from insufficient accuracy, robustness and explanation. In this study, we first take the characteristics of both RNA and RBP into consideration. We propose a method for discriminating circRNA-RBP binding sites based on multi-scale characterizing sequence and structure features, called CRMSS. For circRNAs, we use sequence ${k}hbox{-}{mer}$ embedding and the forming probabilities of local secondary structures as features. For RBPs, we combine sequence and structure frequencies of RNA-binding domain regions to generate features. We capture binding patterns with multi-scale residual blocks. With BiLSTM and attention mechanism, we obtain the contextual information of high-level representation for circRNA-RBP binding. To validate the effectiveness of CRMSS, we compare its predictive performance with other methods on 37 RBPs. Taking the properties of both circRNAs and RBPs into account, CRMSS achieves superior performance over state-of-the-art methods. In the case study, our model provides reliable predictions and correctly identifies experimentally verified circRNA-RBP pairs. The code of CRMSS is freely available at https://github.com/BioinformaticsCSU/CRMSS." @default.
• W4311282580 created "2022-12-25" @default.
• W4311282580 creator A5001547268 @default.
• W4311282580 creator A5033885404 @default.
• W4311282580 creator A5065367210 @default.
• W4311282580 creator A5074706280 @default.
• W4311282580 creator A5079316675 @default.
• W4311282580 date "2022-12-12" @default.
• W4311282580 modified "2023-10-16" @default.
• W4311282580 title "CRMSS: predicting circRNA-RBP binding sites based on multi-scale characterizing sequence and structure features" @default.
• W4311282580 cites W1846631206 @default.
• W4311282580 cites W1951403192 @default.
• W4311282580 cites W1966557314 @default.
• W4311282580 cites W1982267716 @default.
• W4311282580 cites W1997535872 @default.
• W4311282580 cites W2054891772 @default.
• W4311282580 cites W2058835062 @default.
• W4311282580 cites W2103375140 @default.
• W4311282580 cites W2112189313 @default.
• W4311282580 cites W2112714817 @default.
• W4311282580 cites W2115662330 @default.
• W4311282580 cites W2131774270 @default.
• W4311282580 cites W2147526198 @default.
• W4311282580 cites W2147625377 @default.
• W4311282580 cites W2157009395 @default.
• W4311282580 cites W2170747616 @default.
• W4311282580 cites W2210577735 @default.
• W4311282580 cites W2266356262 @default.
• W4311282580 cites W2335285947 @default.
• W4311282580 cites W2572160591 @default.
• W4311282580 cites W2581834730 @default.
• W4311282580 cites W2712900661 @default.
• W4311282580 cites W2795917193 @default.
• W4311282580 cites W2890017579 @default.
• W4311282580 cites W2949078846 @default.
• W4311282580 cites W2963923670 @default.
• W4311282580 cites W2963963068 @default.
• W4311282580 cites W2971655612 @default.
• W4311282580 cites W2973586775 @default.
• W4311282580 cites W2979844864 @default.
• W4311282580 cites W2987161606 @default.
• W4311282580 cites W2991019646 @default.
• W4311282580 cites W3000546304 @default.
• W4311282580 cites W3014677172 @default.
• W4311282580 cites W3026425509 @default.
• W4311282580 cites W3042874372 @default.
• W4311282580 cites W3049603460 @default.
• W4311282580 cites W3085038881 @default.
• W4311282580 cites W3095596981 @default.
• W4311282580 cites W3117084002 @default.
• W4311282580 cites W3119055990 @default.
• W4311282580 cites W3130271948 @default.
• W4311282580 cites W3162914601 @default.
• W4311282580 cites W3163595068 @default.
• W4311282580 cites W4206702527 @default.
• W4311282580 cites W4226153075 @default.
• W4311282580 cites W4280638470 @default.
• W4311282580 doi "https://doi.org/10.1093/bib/bbac530" @default.
• W4311282580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36511222" @default.
• W4311282580 hasPublicationYear "2022" @default.
• W4311282580 type Work @default.
• W4311282580 citedByCount "2" @default.
• W4311282580 countsByYear W43112825802023 @default.
• W4311282580 crossrefType "journal-article" @default.
• W4311282580 hasAuthorship W4311282580A5001547268 @default.
• W4311282580 hasAuthorship W4311282580A5033885404 @default.
• W4311282580 hasAuthorship W4311282580A5065367210 @default.
• W4311282580 hasAuthorship W4311282580A5074706280 @default.
• W4311282580 hasAuthorship W4311282580A5079316675 @default.
• W4311282580 hasConcept C104317684 @default.
• W4311282580 hasConcept C154945302 @default.
• W4311282580 hasConcept C17744445 @default.
• W4311282580 hasConcept C199539241 @default.
• W4311282580 hasConcept C2776359362 @default.
• W4311282580 hasConcept C2778112365 @default.
• W4311282580 hasConcept C41008148 @default.
• W4311282580 hasConcept C41282012 @default.
• W4311282580 hasConcept C41608201 @default.
• W4311282580 hasConcept C54355233 @default.
• W4311282580 hasConcept C63479239 @default.
• W4311282580 hasConcept C67705224 @default.
• W4311282580 hasConcept C70721500 @default.
• W4311282580 hasConcept C86803240 @default.
• W4311282580 hasConcept C94625758 @default.
• W4311282580 hasConceptScore W4311282580C104317684 @default.
• W4311282580 hasConceptScore W4311282580C154945302 @default.
• W4311282580 hasConceptScore W4311282580C17744445 @default.
• W4311282580 hasConceptScore W4311282580C199539241 @default.
• W4311282580 hasConceptScore W4311282580C2776359362 @default.
• W4311282580 hasConceptScore W4311282580C2778112365 @default.
• W4311282580 hasConceptScore W4311282580C41008148 @default.
• W4311282580 hasConceptScore W4311282580C41282012 @default.
• W4311282580 hasConceptScore W4311282580C41608201 @default.
• W4311282580 hasConceptScore W4311282580C54355233 @default.
• W4311282580 hasConceptScore W4311282580C63479239 @default.
• W4311282580 hasConceptScore W4311282580C67705224 @default.
• W4311282580 hasConceptScore W4311282580C70721500 @default.
• W4311282580 hasConceptScore W4311282580C86803240 @default.
• W4311282580 hasConceptScore W4311282580C94625758 @default.
• W4311282580 hasFunder F4320321001 @default.

• next