Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311286630> ?p ?o ?g. }
- W4311286630 endingPage "488" @default.
- W4311286630 startingPage "481" @default.
- W4311286630 abstract "Protein aggregation is an obstacle for the development of new biopharmaceuticals, presenting challenges in shipping and storage of vital therapies. Though a variety of materials and methods have been explored, the need remains for a simple material that is biodegradable, nontoxic, and highly efficient at stabilizing protein therapeutics. In this work, we investigated zwitterionic polypeptides prepared using a rapid and scalable polymerization technique and conjugated to a supramolecular macrocycle host, cucurbit[7]uril, for the ability to inhibit aggregation of model protein therapeutics insulin and calcitonin. The polypeptides are based on the natural amino acid methionine, and zwitterion sulfonium modifications were compared to analogous cationic and neutral structures. Each polymer was end-modified with a single cucurbit[7]uril macrocycle to afford supramolecular recognition and binding to terminal aromatic amino acids on proteins. Only conjugates prepared from zwitterionic structures of sufficient chain lengths were efficient inhibitors of insulin aggregation and could also inhibit aggregation of calcitonin. This polypeptide exhibited no cytotoxicity in human cells even at concentrations that were five-fold of the intended therapeutic regime. We explored treatment of the zwitterionic polypeptides with a panel of natural proteases and found steady biodegradation as expected, supporting eventual clearance when used as a protein formulation additive." @default.
- W4311286630 created "2022-12-25" @default.
- W4311286630 creator A5005469350 @default.
- W4311286630 creator A5015414672 @default.
- W4311286630 creator A5034545287 @default.
- W4311286630 creator A5048991045 @default.
- W4311286630 creator A5049948902 @default.
- W4311286630 creator A5058846419 @default.
- W4311286630 creator A5071945184 @default.
- W4311286630 creator A5088880447 @default.
- W4311286630 date "2022-12-13" @default.
- W4311286630 modified "2023-10-18" @default.
- W4311286630 title "Supramolecular Protein Stabilization with Zwitterionic Polypeptide–Cucurbit[7]uril Conjugates" @default.
- W4311286630 cites W1587071366 @default.
- W4311286630 cites W1965507089 @default.
- W4311286630 cites W1971037034 @default.
- W4311286630 cites W1972260684 @default.
- W4311286630 cites W1977419716 @default.
- W4311286630 cites W1982727647 @default.
- W4311286630 cites W1982810365 @default.
- W4311286630 cites W1986306941 @default.
- W4311286630 cites W1988089792 @default.
- W4311286630 cites W1988972257 @default.
- W4311286630 cites W1989891753 @default.
- W4311286630 cites W1994384674 @default.
- W4311286630 cites W1995341014 @default.
- W4311286630 cites W1997132514 @default.
- W4311286630 cites W2004847937 @default.
- W4311286630 cites W2006741541 @default.
- W4311286630 cites W2027191063 @default.
- W4311286630 cites W2029604755 @default.
- W4311286630 cites W2033659997 @default.
- W4311286630 cites W2039227708 @default.
- W4311286630 cites W2042614258 @default.
- W4311286630 cites W2044036144 @default.
- W4311286630 cites W2046761749 @default.
- W4311286630 cites W2048173065 @default.
- W4311286630 cites W2055230590 @default.
- W4311286630 cites W2056756210 @default.
- W4311286630 cites W2058865733 @default.
- W4311286630 cites W2070623737 @default.
- W4311286630 cites W2071095038 @default.
- W4311286630 cites W2079240371 @default.
- W4311286630 cites W2081640562 @default.
- W4311286630 cites W2083951623 @default.
- W4311286630 cites W2087912205 @default.
- W4311286630 cites W2095212680 @default.
- W4311286630 cites W2097137303 @default.
- W4311286630 cites W2097447449 @default.
- W4311286630 cites W2100974520 @default.
- W4311286630 cites W2112844927 @default.
- W4311286630 cites W2126061397 @default.
- W4311286630 cites W2131044479 @default.
- W4311286630 cites W2138606809 @default.
- W4311286630 cites W2149138461 @default.
- W4311286630 cites W2236338088 @default.
- W4311286630 cites W2298205579 @default.
- W4311286630 cites W2301521579 @default.
- W4311286630 cites W2316924342 @default.
- W4311286630 cites W2341223439 @default.
- W4311286630 cites W2407661745 @default.
- W4311286630 cites W2410105619 @default.
- W4311286630 cites W2418409367 @default.
- W4311286630 cites W2559177805 @default.
- W4311286630 cites W2563609397 @default.
- W4311286630 cites W2587584959 @default.
- W4311286630 cites W2604584550 @default.
- W4311286630 cites W2788184323 @default.
- W4311286630 cites W2791492523 @default.
- W4311286630 cites W2912400841 @default.
- W4311286630 cites W2924441574 @default.
- W4311286630 cites W2996387778 @default.
- W4311286630 cites W3003030778 @default.
- W4311286630 cites W3021647661 @default.
- W4311286630 cites W3023222482 @default.
- W4311286630 cites W3029667329 @default.
- W4311286630 cites W3046633757 @default.
- W4311286630 cites W3183862157 @default.
- W4311286630 cites W3210951944 @default.
- W4311286630 cites W3216165129 @default.
- W4311286630 doi "https://doi.org/10.1021/acs.biomac.2c01319" @default.
- W4311286630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36512327" @default.
- W4311286630 hasPublicationYear "2022" @default.
- W4311286630 type Work @default.
- W4311286630 citedByCount "1" @default.
- W4311286630 countsByYear W43112866302023 @default.
- W4311286630 crossrefType "journal-article" @default.
- W4311286630 hasAuthorship W4311286630A5005469350 @default.
- W4311286630 hasAuthorship W4311286630A5015414672 @default.
- W4311286630 hasAuthorship W4311286630A5034545287 @default.
- W4311286630 hasAuthorship W4311286630A5048991045 @default.
- W4311286630 hasAuthorship W4311286630A5049948902 @default.
- W4311286630 hasAuthorship W4311286630A5058846419 @default.
- W4311286630 hasAuthorship W4311286630A5071945184 @default.
- W4311286630 hasAuthorship W4311286630A5088880447 @default.
- W4311286630 hasConcept C136238340 @default.
- W4311286630 hasConcept C178790620 @default.
- W4311286630 hasConcept C183882617 @default.