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- W4311287275 abstract "Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of cellular processes. Growing evidence shows that dynamic regulation of histone methylation is critical for almost all stages of development. Notably, the KDM5 subfamily of histone lysine-specific demethylases plays essential roles in the proper development and differentiation of tissues, and aberrant regulation of KDM5 proteins during development can lead to chronic developmental defects and even cancer. In this review, we adopt a unique perspective regarding the context-dependent roles of KDM5A and KDM5B in development and tumorigenesis. It is well known that these two proteins show a high degree of sequence homology, with overlapping functions. However, we provide deeper insights into their substrate specificity and distinctive function in gene regulation that at times divert from each other. We also highlight both the possibility of targeting KDM5A and KDM5B to improve cancer treatment and the limitations that must be overcome to increase the efficacy of current drugs." @default.
- W4311287275 created "2022-12-25" @default.
- W4311287275 creator A5004664878 @default.
- W4311287275 creator A5018005596 @default.
- W4311287275 creator A5036928861 @default.
- W4311287275 creator A5056109836 @default.
- W4311287275 creator A5059738637 @default.
- W4311287275 creator A5065896234 @default.
- W4311287275 date "2022-12-12" @default.
- W4311287275 modified "2023-10-13" @default.
- W4311287275 title "Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis" @default.
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