Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311299900> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4311299900 endingPage "iii5" @default.
- W4311299900 startingPage "iii5" @default.
- W4311299900 abstract "Abstract Introduction We investigated HSVTK/GCV suicide gene therapy for malignant glioma, and demonstrated the migration ability and antitumor effect of various tissue-derived pluripotent stem cells. In recent years, stem cells from human exfoliated deciduous teeth (SHED), which have excellent ethical and self-renewal ability, have attracted attention, especially in regenerative medicine. In this study, using SHEDTK transfected with TK, we examined the migration ability and antitumor effect against malignant glioma and metastasis models. Methods In vitro assay: Using Matrigel chamber, the migration ability of SHEDTK to conditioned medium (CM) of glioma cells, lung carcinoma cells, and various tumor growth factors (TGF) was examined. The antitumor effect was examined for cell viability by co-culturing SHEDTK and each tumor cell under the addition of GCV. in vivo assay: Using glioma model mice, SHEDTK migrating around the tumor was confirmed in brain sections. In addition, we co-implanted SHEDTK and administered GCV to glioma and metastasis model as therapeutic models, evaluated tumor reduction effect by bioluminescence, and confirmed survival curves. Results In vitro assay: SHEDTK significantly migrated to CM and TGF compared to control. The antitumor effect was observed even when the ratio of each tumor cell to SHEDTK was 128-256 times. in vivo assay: In glioma model mice, SHEDTK migrated around contralateral tumor. In the treatment experiment, the control group died of tumors, whereas the tumor in the treatment group disappeared within the period of GCV administration, and they survived without neurological deficits until 100 days later, and the overall survival time was improved with a statistically significant difference. Conclusions We confirmed the migration ability and antitumor effect of SHEDTK on malignant glioma and metastasis models. Suicide gene therapy using SHEDTK was suggested as novel gene therapy. In the future, we plan to conduct translational research such as preclinical studies and physician -initiated clinical trials." @default.
- W4311299900 created "2022-12-25" @default.
- W4311299900 creator A5021127603 @default.
- W4311299900 creator A5023817429 @default.
- W4311299900 creator A5043354042 @default.
- W4311299900 creator A5044162364 @default.
- W4311299900 creator A5050961061 @default.
- W4311299900 creator A5059538840 @default.
- W4311299900 creator A5060249195 @default.
- W4311299900 creator A5086647118 @default.
- W4311299900 date "2022-12-01" @default.
- W4311299900 modified "2023-10-18" @default.
- W4311299900 title "ET-5 POTENT BYSTANDER EFFECT IN SUICIDE GENE THERAPY USING TK-EXPRESSING STEM CELLS FROM HUMAN EXFOLIATED DECIDUOUS TEETH" @default.
- W4311299900 doi "https://doi.org/10.1093/noajnl/vdac167.017" @default.
- W4311299900 hasPublicationYear "2022" @default.
- W4311299900 type Work @default.
- W4311299900 citedByCount "0" @default.
- W4311299900 crossrefType "journal-article" @default.
- W4311299900 hasAuthorship W4311299900A5021127603 @default.
- W4311299900 hasAuthorship W4311299900A5023817429 @default.
- W4311299900 hasAuthorship W4311299900A5043354042 @default.
- W4311299900 hasAuthorship W4311299900A5044162364 @default.
- W4311299900 hasAuthorship W4311299900A5050961061 @default.
- W4311299900 hasAuthorship W4311299900A5059538840 @default.
- W4311299900 hasAuthorship W4311299900A5060249195 @default.
- W4311299900 hasAuthorship W4311299900A5086647118 @default.
- W4311299900 hasBestOaLocation W43112999001 @default.
- W4311299900 hasConcept C104317684 @default.
- W4311299900 hasConcept C111335760 @default.
- W4311299900 hasConcept C111599444 @default.
- W4311299900 hasConcept C121608353 @default.
- W4311299900 hasConcept C126322002 @default.
- W4311299900 hasConcept C142724271 @default.
- W4311299900 hasConcept C150903083 @default.
- W4311299900 hasConcept C161997846 @default.
- W4311299900 hasConcept C207001950 @default.
- W4311299900 hasConcept C2778227246 @default.
- W4311299900 hasConcept C2778608917 @default.
- W4311299900 hasConcept C2779013556 @default.
- W4311299900 hasConcept C2780394083 @default.
- W4311299900 hasConcept C28328180 @default.
- W4311299900 hasConcept C34981463 @default.
- W4311299900 hasConcept C502942594 @default.
- W4311299900 hasConcept C54009773 @default.
- W4311299900 hasConcept C54355233 @default.
- W4311299900 hasConcept C55493867 @default.
- W4311299900 hasConcept C71924100 @default.
- W4311299900 hasConcept C81885089 @default.
- W4311299900 hasConcept C86803240 @default.
- W4311299900 hasConcept C95444343 @default.
- W4311299900 hasConceptScore W4311299900C104317684 @default.
- W4311299900 hasConceptScore W4311299900C111335760 @default.
- W4311299900 hasConceptScore W4311299900C111599444 @default.
- W4311299900 hasConceptScore W4311299900C121608353 @default.
- W4311299900 hasConceptScore W4311299900C126322002 @default.
- W4311299900 hasConceptScore W4311299900C142724271 @default.
- W4311299900 hasConceptScore W4311299900C150903083 @default.
- W4311299900 hasConceptScore W4311299900C161997846 @default.
- W4311299900 hasConceptScore W4311299900C207001950 @default.
- W4311299900 hasConceptScore W4311299900C2778227246 @default.
- W4311299900 hasConceptScore W4311299900C2778608917 @default.
- W4311299900 hasConceptScore W4311299900C2779013556 @default.
- W4311299900 hasConceptScore W4311299900C2780394083 @default.
- W4311299900 hasConceptScore W4311299900C28328180 @default.
- W4311299900 hasConceptScore W4311299900C34981463 @default.
- W4311299900 hasConceptScore W4311299900C502942594 @default.
- W4311299900 hasConceptScore W4311299900C54009773 @default.
- W4311299900 hasConceptScore W4311299900C54355233 @default.
- W4311299900 hasConceptScore W4311299900C55493867 @default.
- W4311299900 hasConceptScore W4311299900C71924100 @default.
- W4311299900 hasConceptScore W4311299900C81885089 @default.
- W4311299900 hasConceptScore W4311299900C86803240 @default.
- W4311299900 hasConceptScore W4311299900C95444343 @default.
- W4311299900 hasIssue "Supplement_3" @default.
- W4311299900 hasLocation W43112999001 @default.
- W4311299900 hasLocation W43112999002 @default.
- W4311299900 hasOpenAccess W4311299900 @default.
- W4311299900 hasPrimaryLocation W43112999001 @default.
- W4311299900 hasRelatedWork W1969367773 @default.
- W4311299900 hasRelatedWork W2092073895 @default.
- W4311299900 hasRelatedWork W2132815178 @default.
- W4311299900 hasRelatedWork W2360750280 @default.
- W4311299900 hasRelatedWork W2362977908 @default.
- W4311299900 hasRelatedWork W2386342238 @default.
- W4311299900 hasRelatedWork W3092226397 @default.
- W4311299900 hasRelatedWork W3149598042 @default.
- W4311299900 hasRelatedWork W4311299900 @default.
- W4311299900 hasRelatedWork W3146686734 @default.
- W4311299900 hasVolume "4" @default.
- W4311299900 isParatext "false" @default.
- W4311299900 isRetracted "false" @default.
- W4311299900 workType "article" @default.