FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311301419> ?p ?o ?g. }

• W4311301419 abstract "Liquid biopsy has been widely researched for early diagnosis, prognostication and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for early-stage non-small cell lung cancer (NSCLC).We performed a meta-analysis and systematic review to evaluate diagnostic and prognostic values of liquid biopsy for early-stage NSCLC, regarding the common biomarkers, circulating tumor cells, circulating tumor DNA (ctDNA), methylation signatures, and microRNAs. Cochrane Library, PubMed, EMBASE databases, ClinicalTrials.gov, and reference lists were searched for eligible studies since inception to 17 May 2022. Sensitivity, specificity and area under the curve (AUC) were assessed for diagnostic values. Hazard ratio (HR) with a 95% confidence interval (CI) was extracted from the recurrence-free survival (RFS) and overall survival (OS) plots for prognostic analysis. Also, potential predictive values and treatment response evaluation were further investigated.In this meta-analysis, there were 34 studies eligible for diagnostic assessment and 21 for prognostic analysis. The estimated diagnostic values of biomarkers for early-stage NSCLC with AUCs ranged from 0.84 to 0.87. The factors TNM stage I, T1 stage, N0 stage, adenocarcinoma, young age, and nonsmoking contributed to a lower tumor burden, with a median cell-free DNA concentration of 8.64 ng/ml. For prognostic analysis, the presence of molecular residual disease (MRD) detection was a strong predictor of disease relapse (RFS, HR, 4.95; 95% CI, 3.06-8.02; p < 0.001) and inferior OS (HR, 3.93; 95% CI, 1.97-7.83; p < 0.001), with average lead time of 179 ± 74 days between molecular recurrence and radiographic progression. Predictive values analysis showed adjuvant therapy significantly benefited the RFS of MRD + patients (HR, 0.27; p < 0.001), while an opposite tendency was detected for MRD - patients (HR, 1.51; p = 0.19). For treatment response evaluation, a strong correlation between pathological response and ctDNA clearance was detected, and both were associated with longer survival after neoadjuvant therapy.In conclusion, our study indicated liquid biopsy could reliably facilitate more precision and effective management of early-stage NSCLC. Improvement of liquid biopsy techniques and detection approaches and platforms is still needed, and higher-quality trials are required to provide more rigorous evidence prior to their routine clinical application." @default.
• W4311301419 created "2022-12-25" @default.
• W4311301419 creator A5001589062 @default.
• W4311301419 creator A5003850660 @default.
• W4311301419 creator A5006822602 @default.
• W4311301419 creator A5009303429 @default.
• W4311301419 creator A5019506454 @default.
• W4311301419 creator A5024572557 @default.
• W4311301419 creator A5032020402 @default.
• W4311301419 creator A5042241049 @default.
• W4311301419 creator A5057429372 @default.
• W4311301419 creator A5067838350 @default.
• W4311301419 creator A5089358409 @default.
• W4311301419 creator A5016774155 @default.
• W4311301419 date "2022-12-14" @default.
• W4311301419 modified "2023-10-14" @default.
• W4311301419 title "Potential clinical utility of liquid biopsy in early-stage non-small cell lung cancer" @default.
• W4311301419 cites W130099911 @default.
• W4311301419 cites W1534181333 @default.
• W4311301419 cites W1946667655 @default.
• W4311301419 cites W1966566182 @default.
• W4311301419 cites W1983466841 @default.
• W4311301419 cites W2005098328 @default.
• W4311301419 cites W2025355337 @default.
• W4311301419 cites W2027786292 @default.
• W4311301419 cites W2075642745 @default.
• W4311301419 cites W2088095316 @default.
• W4311301419 cites W2102576865 @default.
• W4311301419 cites W2107638293 @default.
• W4311301419 cites W2126727011 @default.
• W4311301419 cites W2128100842 @default.
• W4311301419 cites W2141730018 @default.
• W4311301419 cites W2152474505 @default.
• W4311301419 cites W2170892587 @default.
• W4311301419 cites W2344118478 @default.
• W4311301419 cites W2387546067 @default.
• W4311301419 cites W2411182714 @default.
• W4311301419 cites W2608738563 @default.
• W4311301419 cites W266360251 @default.
• W4311301419 cites W2747530723 @default.
• W4311301419 cites W2747939174 @default.
• W4311301419 cites W2750926847 @default.
• W4311301419 cites W2754606968 @default.
• W4311301419 cites W2755497557 @default.
• W4311301419 cites W2761253587 @default.
• W4311301419 cites W2762340878 @default.
• W4311301419 cites W2783674487 @default.
• W4311301419 cites W2810592374 @default.
• W4311301419 cites W2896980303 @default.
• W4311301419 cites W2897229272 @default.
• W4311301419 cites W2899540665 @default.
• W4311301419 cites W2899697641 @default.
• W4311301419 cites W2900771557 @default.
• W4311301419 cites W2902808460 @default.
• W4311301419 cites W2905051664 @default.
• W4311301419 cites W2917102036 @default.
• W4311301419 cites W2937196653 @default.
• W4311301419 cites W2939529287 @default.
• W4311301419 cites W2941215746 @default.
• W4311301419 cites W2947989913 @default.
• W4311301419 cites W2950673824 @default.
• W4311301419 cites W2955252260 @default.
• W4311301419 cites W2969593960 @default.
• W4311301419 cites W2985750654 @default.
• W4311301419 cites W2993776289 @default.
• W4311301419 cites W3000712054 @default.
• W4311301419 cites W3004929071 @default.
• W4311301419 cites W3010573433 @default.
• W4311301419 cites W3012453990 @default.
• W4311301419 cites W3013146920 @default.
• W4311301419 cites W3013924915 @default.
• W4311301419 cites W3028644610 @default.
• W4311301419 cites W3034531160 @default.
• W4311301419 cites W3036887862 @default.
• W4311301419 cites W3046542216 @default.
• W4311301419 cites W3082829449 @default.
• W4311301419 cites W3085851693 @default.
• W4311301419 cites W3089864405 @default.
• W4311301419 cites W3110953136 @default.
• W4311301419 cites W3118615836 @default.
• W4311301419 cites W3123940477 @default.
• W4311301419 cites W3126502243 @default.
• W4311301419 cites W3126888017 @default.
• W4311301419 cites W3128646645 @default.
• W4311301419 cites W3131208308 @default.
• W4311301419 cites W3135214901 @default.
• W4311301419 cites W3151454118 @default.
• W4311301419 cites W3160382304 @default.
• W4311301419 cites W3164117097 @default.
• W4311301419 cites W3166379906 @default.
• W4311301419 cites W3182327288 @default.
• W4311301419 cites W3183882835 @default.
• W4311301419 cites W3190919568 @default.
• W4311301419 cites W3194069390 @default.
• W4311301419 cites W3198152132 @default.
• W4311301419 cites W3207610981 @default.
• W4311301419 cites W3214051991 @default.
• W4311301419 cites W3214322235 @default.
• W4311301419 cites W4200147408 @default.
• W4311301419 cites W4200224812 @default.

• next