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- W4311303726 abstract "Normothermic machine perfusion (NMP) has not yet been established as a technique for preserving organs for a day. A key contributing factor to the same is that the perfusing solutions cannot circulate continuously and evenly in the organs. Here, we conceived a method of applying intermittent air pressure from outside the organ to assist its circulatory distribution during perfusion. We used a perfusion culture system while applying external pressure to culture rat kidneys and compared the circulatory distribution in the kidneys, changes in tissue morphology due to injury, and perfusate filtration. The intermittent pressurization (IMP) (-) group showed markedly poorer circulation on the upper side compared with that in the lower side, alongside histological damage. On the other hand, the IMP (+) group showed improved circulation in the upper side and had lesser histological damage. Furthermore, the IMP (+) group maintained the ability to filter perfusate for 24 h. In transplantation medicine and regenerative medicine research, this method has the potential to contribute to more efficient organ preservation and more functional tissue regeneration in the future." @default.
- W4311303726 created "2022-12-25" @default.
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- W4311303726 date "2022-12-13" @default.
- W4311303726 modified "2023-10-09" @default.
- W4311303726 title "External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion" @default.
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- W4311303726 doi "https://doi.org/10.1038/s41598-022-26147-5" @default.
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