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- W4311307926 abstract "Catalytic DNA-based fluorescent sensors have enabled cellular imaging of metal ions such as Mg2+ . However, natural DNA is prone to nuclease-mediated degradation. Here, we report the in vitro selection of threose nucleic acid enzymes (TNAzymes) with RNA endonuclease activities. One such TNAzyme, T17-22, catalyzes a site-specific RNA cleavage reaction with a kcat of 0.017 min-1 and KM of 675 nM. A fluorescent sensor based on T17-22 responds to an increasing concentration of Mg2+ with a limit of detection at 0.35 mM. This TNAzyme-based sensor also allows cellular imaging of Mg2+ . This work presents the first proof-of-concept demonstration of using a TNA catalyst in cellular metal ion imaging." @default.
- W4311307926 created "2022-12-25" @default.
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- W4311307926 date "2023-01-18" @default.
- W4311307926 modified "2023-09-26" @default.
- W4311307926 title "Selection of RNA‐Cleaving TNA Enzymes for Cellular Mg <sup>2+</sup> Imaging" @default.
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- W4311307926 doi "https://doi.org/10.1002/cbic.202200651" @default.
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