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• W4311310366 abstract "Melatonin can exert some of its functions by binding to specific membrane receptors, mainly MT1 and MT2 in mammals. The melatonin receptor 1A (MTNR1A) gene exhibits several polymorphic sites. Certain RsaI genotypes have been related to an advance in the mating activity of ram-lambs or to a more intense reproductive behavior in adult rams. However, the influence of those genotypes in the location of melatonin receptors in ram spermatozoa remains unknown. The aim of this work was to evaluate whether RsaI polymorphisms of the MTNR1A gene influence the cellular distribution of MT1 and MT2 receptors in ram sperm. For this purpose, ejaculates from 18 previously genotyped Rasa Aragonesa rams were collected, and the location of melatonin receptors was assessed by indirect immunofluorescence, using anti-MT1 (Abnova Corporation, Cat# H00004543- A01, RRID: AB_462681) and anti-MT2 (OriGene, Cat#AP01322PU-N, RRID: AB_1619198) antibodies. Statistical analysis (χ²) was performed using SPSS Statistics v.26. For the MT1 receptor, G/A rams had a higher percentage of type I spermatozoa (labelling all over the head and tail) but lower rates of immunotypes II (reactivity at the equatorial and post-acrosomal regions, neck and tail) and III (only the equatorial region and tail labelled) when compared to G/G and A/A rams (P<0.01). Immunotype IV (only the flagelum stained) was also lower in G/A rams than in G/G (P<0.05). For the MT2 receptor, G/A rams had higher percentages of type AP spermatozoa (acrosome and post- acrosome equally stained), and lower percentages of type A (more intensity in acrosome than post-acrosome) when compared to G/G and A/A rams (P<0.001). Furthermore, G/G rams had a higher percentage of type P spermatozoa (more intense staining on post- acrosome than acrosome) than G/A and A/A rams (P<0.01). In conclusion, these results suggested that polymorphisms of the MTNR1A gene could influence the distribution of MT1 and MT2 receptors in ram sperm, which could have consequences on the direct effects of melatonin on spermatozoa. [Research supported by PID2020-113239RB-I00 and A07_20R. V.P-D. has a predoctoral contract from the Diputación General de Aragón]" @default.
• W4311310366 created "2022-12-25" @default.
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• W4311310366 date "2022-12-01" @default.
• W4311310366 modified "2023-09-30" @default.
• W4311310366 title "Influence of the polymorphisms of the melatonin receptor 1A (MTNR1A) gene on the distribution of MT1 and MT2 melatonin receptors in ram sperm" @default.
• W4311310366 doi "https://doi.org/10.1016/j.anireprosci.2022.107138" @default.
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