Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311331036> ?p ?o ?g. }
- W4311331036 abstract "Breast cancer displays disparities in mortality between African Americans and Caucasian Americans. However, the exact molecular mechanisms remain elusive. Here, we identify miR-1304-3p as the most upregulated microRNA in African American patients. Importantly, its expression significantly correlates with poor progression-free survival in African American patients. Ectopic expression of miR-1304 promotes tumor progression in vivo. Exosomal miR-1304-3p activates cancer-associated adipocytes that release lipids and enhance cancer cell growth. Moreover, we identify the anti-adipogenic gene GATA2 as the target of miR-1304-3p. Notably, a single nucleotide polymorphism (SNP) located in the miR-1304 stem-loop region shows a significant difference in frequencies of the G allele between African and Caucasian American groups, which promotes the maturation of miR-1304-3p. Therefore, our results reveal a mechanism of the disparity in breast cancer progression and suggest a potential utility of miR-1304-3p and the associated SNP as biomarkers for predicting the outcome of African American patients." @default.
- W4311331036 created "2022-12-25" @default.
- W4311331036 creator A5002327206 @default.
- W4311331036 creator A5002422880 @default.
- W4311331036 creator A5011443826 @default.
- W4311331036 creator A5020022960 @default.
- W4311331036 creator A5029680030 @default.
- W4311331036 creator A5039382964 @default.
- W4311331036 creator A5046135518 @default.
- W4311331036 creator A5074668225 @default.
- W4311331036 creator A5087770835 @default.
- W4311331036 creator A5089547723 @default.
- W4311331036 creator A5091029117 @default.
- W4311331036 date "2022-12-14" @default.
- W4311331036 modified "2023-10-16" @default.
- W4311331036 title "Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes" @default.
- W4311331036 cites W1566143144 @default.
- W4311331036 cites W1582471009 @default.
- W4311331036 cites W1669533272 @default.
- W4311331036 cites W1850481091 @default.
- W4311331036 cites W1893680466 @default.
- W4311331036 cites W196558497 @default.
- W4311331036 cites W1965776038 @default.
- W4311331036 cites W1975355918 @default.
- W4311331036 cites W1977859620 @default.
- W4311331036 cites W2008085098 @default.
- W4311331036 cites W2024910251 @default.
- W4311331036 cites W2026855866 @default.
- W4311331036 cites W2036468147 @default.
- W4311331036 cites W2075496997 @default.
- W4311331036 cites W2087813533 @default.
- W4311331036 cites W2103337198 @default.
- W4311331036 cites W2115093090 @default.
- W4311331036 cites W2127424952 @default.
- W4311331036 cites W2130305733 @default.
- W4311331036 cites W2135287872 @default.
- W4311331036 cites W2141320958 @default.
- W4311331036 cites W2143839116 @default.
- W4311331036 cites W2151451331 @default.
- W4311331036 cites W2164334572 @default.
- W4311331036 cites W2166311434 @default.
- W4311331036 cites W2169238980 @default.
- W4311331036 cites W2179438025 @default.
- W4311331036 cites W2190836196 @default.
- W4311331036 cites W2338191132 @default.
- W4311331036 cites W2414332811 @default.
- W4311331036 cites W2475241423 @default.
- W4311331036 cites W2523012281 @default.
- W4311331036 cites W2546967094 @default.
- W4311331036 cites W2567639438 @default.
- W4311331036 cites W2575010601 @default.
- W4311331036 cites W2589411605 @default.
- W4311331036 cites W2605515535 @default.
- W4311331036 cites W2664719658 @default.
- W4311331036 cites W2744657869 @default.
- W4311331036 cites W2774031974 @default.
- W4311331036 cites W2783562764 @default.
- W4311331036 cites W2789976756 @default.
- W4311331036 cites W2797145001 @default.
- W4311331036 cites W2800218175 @default.
- W4311331036 cites W2805156641 @default.
- W4311331036 cites W2806738650 @default.
- W4311331036 cites W2883027795 @default.
- W4311331036 cites W2889555506 @default.
- W4311331036 cites W2895610618 @default.
- W4311331036 cites W2895748484 @default.
- W4311331036 cites W2897316087 @default.
- W4311331036 cites W2897825874 @default.
- W4311331036 cites W2898602868 @default.
- W4311331036 cites W2904628185 @default.
- W4311331036 cites W2909876769 @default.
- W4311331036 cites W2913603460 @default.
- W4311331036 cites W2913872740 @default.
- W4311331036 cites W2918113141 @default.
- W4311331036 cites W2929442226 @default.
- W4311331036 cites W2937501395 @default.
- W4311331036 cites W2945972089 @default.
- W4311331036 cites W2947486430 @default.
- W4311331036 cites W2972584423 @default.
- W4311331036 cites W2979291688 @default.
- W4311331036 cites W2982045844 @default.
- W4311331036 cites W2982281084 @default.
- W4311331036 cites W2983299555 @default.
- W4311331036 cites W2999417355 @default.
- W4311331036 cites W3000130913 @default.
- W4311331036 cites W3005104290 @default.
- W4311331036 cites W3006242053 @default.
- W4311331036 cites W3008686703 @default.
- W4311331036 cites W3015868071 @default.
- W4311331036 cites W3021061937 @default.
- W4311331036 cites W3028978477 @default.
- W4311331036 cites W3044213557 @default.
- W4311331036 cites W3092973505 @default.
- W4311331036 cites W3097446375 @default.
- W4311331036 cites W3102777791 @default.
- W4311331036 cites W3115980435 @default.
- W4311331036 cites W3119366284 @default.
- W4311331036 cites W3136261983 @default.
- W4311331036 cites W3197685878 @default.
- W4311331036 doi "https://doi.org/10.1038/s41467-022-35305-2" @default.