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• W4311342080 endingPage "100308" @default.
• W4311342080 startingPage "100308" @default.
• W4311342080 abstract "A community COVID-19 outbreak caused by the B.1.1.7 SARS-CoV-2 variant occurred in Taiwan in May 2021. High-risk populations such as people living with HIV (PLWH) were recommended to receive two doses of COVID-19 vaccines. While SARS-CoV-2 vaccines have demonstrated promising results in general population, real-world information on the serological responses remains limited among PLWH. PLWH receiving the first dose of SARS-CoV-2 vaccine from 2020 to 2021 were enrolled. Determinations of anti-SARS-CoV-2 spike IgG titers were performed every one to three months, until PLWH received the third dose of SARS-CoV-2 vaccine or had confirmed SARS-CoV-2 infection. All serum samples were tested for anti-nucleocapsid antibody and those tested positive were excluded from analysis. A total of 1189 PLWH were enrolled: 829 (69.7%) receiving two doses of AZD1222 vaccine, 232 (19.5%) mRNA-1273 vaccine, and 128 (10.8%) BNT162b2 vaccine. Of all time points, PLWH receiving two doses of mRNA vaccines had consistently higher antibody levels than those receiving AZD1222 vaccine (p < 0.001 for all time-point comparisons). Of all PLWH, factors associated with failure to achieve an anti-spike IgG titer >141 BAU/mL within 12 weeks included type 2 diabetes mellitus (DM) (adjusted odds ratio [aOR], 2.24; 95% CI, 1.25–4), CD4 count <200 cells/mm3 upon receipt of the first dose of vaccination (aOR, 3.43; 95% CI, 1.31–9) and two homologous AZD1222 vaccination (aOR, 16.85; 95%CI, 10.13–28). For those receiving two doses of mRNA vaccines, factors associated with failure to achieve an anti-spike IgG titer >899 BAU/mL within 12 weeks were CD4 count <200 cells/mm3 on first-dose vaccination (aOR, 3.95; 95% CI, 1.08–14.42) and dual BNT162b2 vaccination (aOR, 4.21; 95% CI, 2.57–6.89). Two doses of homologous mRNA vaccination achieved significantly higher serological responses than vaccination with AZD1222 among PLWH and PLWH with CD4 counts <200 cells/mm3 and DM had consistently lower serological responses." @default.
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• W4311342080 date "2022-12-01" @default.
• W4311342080 modified "2023-10-05" @default.
• W4311342080 title "Evolution of anti-SARS-CoV-2 spike protein titers after two-dose of COVID-19 vaccination among people living with HIV" @default.
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• W4311342080 doi "https://doi.org/10.1016/j.jve.2022.100308" @default.
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