Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311353852> ?p ?o ?g. }
- W4311353852 abstract "Immune function changes across the life course; the fetal immune system is characterised by tolerance while that of seniors is less able to respond effectively to antigens and is more pro-inflammatory than in younger adults. Lipids are involved centrally in immune function but there is limited information about how T cell lipid metabolism changes during the life course.We investigated whether life stage alters fatty acid composition, lipid droplet content and α-linolenic acid (18:3ω-3) metabolism in human fetal CD3+ T lymphocytes and in CD3+ T lymphocytes from adults (median 41 years) and seniors (median 70 years). Quiescent fetal T cells had higher saturated (SFA), monounsaturated fatty acid (MUFA), and ω-6 polyunsaturated fatty acid (PUFA) contents than adults or seniors. Activation-induced changes in fatty acid composition differed between life stages. The principal metabolic fates of [13C]18:3ω-3 were constitutive hydroxyoctadecatrienoic acid synthesis and β-oxidation and carbon recycling into SFA and MUFA. These processes declined progressively across the life course. Longer chain ω-3 PUFA synthesis was a relatively minor metabolic fate of 18:3ω-3 at all life stages. Fetal and adult T lymphocytes had similar lipid droplet contents, which were lower than in T cells from seniors. Variation in the lipid droplet content of adult T cells accounted for 62% of the variation in mitogen-induced CD69 expression, but there was no significant relationship in fetal cells or lymphocytes from seniors.Together these findings show that fatty acid metabolism in human T lymphocytes changes across the life course in a manner that may facilitate the adaptation of immune function to different life stages." @default.
- W4311353852 created "2022-12-25" @default.
- W4311353852 creator A5016701079 @default.
- W4311353852 creator A5030546346 @default.
- W4311353852 creator A5037364494 @default.
- W4311353852 creator A5064557060 @default.
- W4311353852 creator A5067547623 @default.
- W4311353852 creator A5072466097 @default.
- W4311353852 creator A5085200750 @default.
- W4311353852 creator A5089558621 @default.
- W4311353852 date "2022-12-13" @default.
- W4311353852 modified "2023-10-18" @default.
- W4311353852 title "Fatty acid composition and metabolic partitioning of α-linolenic acid are contingent on life stage in human CD3+ T lymphocytes" @default.
- W4311353852 cites W121310277 @default.
- W4311353852 cites W1560735837 @default.
- W4311353852 cites W1790685842 @default.
- W4311353852 cites W1905885236 @default.
- W4311353852 cites W1914711281 @default.
- W4311353852 cites W1930328534 @default.
- W4311353852 cites W1965671023 @default.
- W4311353852 cites W1966203637 @default.
- W4311353852 cites W1977742452 @default.
- W4311353852 cites W1985093089 @default.
- W4311353852 cites W1995854222 @default.
- W4311353852 cites W1998732178 @default.
- W4311353852 cites W2006933211 @default.
- W4311353852 cites W2013822447 @default.
- W4311353852 cites W2019619794 @default.
- W4311353852 cites W2025785280 @default.
- W4311353852 cites W2038066867 @default.
- W4311353852 cites W2045983090 @default.
- W4311353852 cites W2047319374 @default.
- W4311353852 cites W2048357191 @default.
- W4311353852 cites W2053388585 @default.
- W4311353852 cites W2057877030 @default.
- W4311353852 cites W2059378560 @default.
- W4311353852 cites W2076623706 @default.
- W4311353852 cites W2090008898 @default.
- W4311353852 cites W2092786634 @default.
- W4311353852 cites W2093048744 @default.
- W4311353852 cites W2101841000 @default.
- W4311353852 cites W2108866810 @default.
- W4311353852 cites W2110733435 @default.
- W4311353852 cites W2138577332 @default.
- W4311353852 cites W2165312718 @default.
- W4311353852 cites W2166485047 @default.
- W4311353852 cites W2168526937 @default.
- W4311353852 cites W2183033079 @default.
- W4311353852 cites W2309260766 @default.
- W4311353852 cites W2318465873 @default.
- W4311353852 cites W2321334948 @default.
- W4311353852 cites W2327515496 @default.
- W4311353852 cites W2409608614 @default.
- W4311353852 cites W2431279359 @default.
- W4311353852 cites W2467560467 @default.
- W4311353852 cites W2476626188 @default.
- W4311353852 cites W2509635278 @default.
- W4311353852 cites W2515712756 @default.
- W4311353852 cites W2615237354 @default.
- W4311353852 cites W2625654775 @default.
- W4311353852 cites W2754394790 @default.
- W4311353852 cites W2778260076 @default.
- W4311353852 cites W2783874580 @default.
- W4311353852 cites W2788762366 @default.
- W4311353852 cites W2894707836 @default.
- W4311353852 cites W2912529946 @default.
- W4311353852 cites W2912980960 @default.
- W4311353852 cites W3006222581 @default.
- W4311353852 cites W3033123249 @default.
- W4311353852 cites W3073153751 @default.
- W4311353852 cites W3159750120 @default.
- W4311353852 cites W3169887235 @default.
- W4311353852 cites W3203211868 @default.
- W4311353852 cites W3216509201 @default.
- W4311353852 cites W4225137560 @default.
- W4311353852 cites W4225977271 @default.
- W4311353852 doi "https://doi.org/10.3389/fimmu.2022.1079642" @default.
- W4311353852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36582247" @default.
- W4311353852 hasPublicationYear "2022" @default.
- W4311353852 type Work @default.
- W4311353852 citedByCount "2" @default.
- W4311353852 countsByYear W43113538522023 @default.
- W4311353852 crossrefType "journal-article" @default.
- W4311353852 hasAuthorship W4311353852A5016701079 @default.
- W4311353852 hasAuthorship W4311353852A5030546346 @default.
- W4311353852 hasAuthorship W4311353852A5037364494 @default.
- W4311353852 hasAuthorship W4311353852A5064557060 @default.
- W4311353852 hasAuthorship W4311353852A5067547623 @default.
- W4311353852 hasAuthorship W4311353852A5072466097 @default.
- W4311353852 hasAuthorship W4311353852A5085200750 @default.
- W4311353852 hasAuthorship W4311353852A5089558621 @default.
- W4311353852 hasBestOaLocation W43113538521 @default.
- W4311353852 hasConcept C126322002 @default.
- W4311353852 hasConcept C134018914 @default.
- W4311353852 hasConcept C172680121 @default.
- W4311353852 hasConcept C185592680 @default.
- W4311353852 hasConcept C19038510 @default.
- W4311353852 hasConcept C203014093 @default.
- W4311353852 hasConcept C2776991927 @default.
- W4311353852 hasConcept C2779234561 @default.