Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311356952> ?p ?o ?g. }
- W4311356952 abstract "Alterations in lipid metabolism promote tumor progression. However, the role of lipid metabolism in the occurrence and development of gastric cancer have not been fully clarified.Here, genes that are related to fatty acid metabolism and differentially-expressed between normal and gastric cancer tissues were identified in the TCGA-STAD cohort. The intersection of identified differentially-expressed genes with Geneset was determined to obtain 78 fatty acid metabolism-related genes. The ConsensusClusterPlus R package was used to perform differentially-expressed genes, which yielded divided two gastric cancer subtypes termed cluster 1 and cluster 2.Patients in cluster 2 was found to display poorer prognosis than patients in cluster 1. Using machine learning method to select 8 differentially expressed genes among subtypes to construct fatty acid prognostic risk score model (FARS), which was found to display good prognostic efficacy. We also identified that certain anticancer drugs, such as bortezomib, elesclomol, GW843682X, and nilotinib, showed significant sensitivity in the high FARS score group. RGS2 was selected as the core gene upon an analysis of the gastric cancer single-cell, and Western blotting and immunofluorescence staining results revealed high level of expression of this gene in gastric cancer cells. The results of immunohistochemical staining showed that a large amount of RGS2 was deposited in the stroma in gastric cancer. A pan-cancer analysis also revealed a significant association of RGS2 with TMB, TIDE, and CD8+ T-cell infiltration in other cancer types as well. RGS2 may thus be studied further as a new target for immunotherapy in future studies on gastric cancer.In summary, the FARS model developed here enhances our understanding of lipid metabolism in the TME in gastric cancer, and provides a theoretical basis for predicting tumor prognosis and clinical treatment." @default.
- W4311356952 created "2022-12-25" @default.
- W4311356952 creator A5015544231 @default.
- W4311356952 creator A5025850836 @default.
- W4311356952 creator A5046173951 @default.
- W4311356952 creator A5050921331 @default.
- W4311356952 creator A5071170713 @default.
- W4311356952 creator A5077352796 @default.
- W4311356952 date "2022-12-14" @default.
- W4311356952 modified "2023-09-30" @default.
- W4311356952 title "Fatty acid metabolism is related to the immune microenvironment changes of gastric cancer and RGS2 is a new tumor biomarker" @default.
- W4311356952 cites W1508609604 @default.
- W4311356952 cites W1994181414 @default.
- W4311356952 cites W2008082008 @default.
- W4311356952 cites W2088918354 @default.
- W4311356952 cites W2164078562 @default.
- W4311356952 cites W2265836483 @default.
- W4311356952 cites W2306119948 @default.
- W4311356952 cites W2324487575 @default.
- W4311356952 cites W2345985540 @default.
- W4311356952 cites W2421886702 @default.
- W4311356952 cites W2523687917 @default.
- W4311356952 cites W2559943376 @default.
- W4311356952 cites W2772250549 @default.
- W4311356952 cites W2885965101 @default.
- W4311356952 cites W2901585624 @default.
- W4311356952 cites W2913095286 @default.
- W4311356952 cites W2936706033 @default.
- W4311356952 cites W2992929807 @default.
- W4311356952 cites W2999911931 @default.
- W4311356952 cites W3005198998 @default.
- W4311356952 cites W3035142017 @default.
- W4311356952 cites W3048569636 @default.
- W4311356952 cites W3087539333 @default.
- W4311356952 cites W3089567818 @default.
- W4311356952 cites W3117340121 @default.
- W4311356952 cites W3138512260 @default.
- W4311356952 cites W3153583567 @default.
- W4311356952 cites W3156923914 @default.
- W4311356952 cites W3164014129 @default.
- W4311356952 cites W3166362230 @default.
- W4311356952 cites W3171853182 @default.
- W4311356952 cites W3183998003 @default.
- W4311356952 cites W3186222380 @default.
- W4311356952 cites W4206056036 @default.
- W4311356952 cites W4282927003 @default.
- W4311356952 cites W4283212597 @default.
- W4311356952 cites W4288009840 @default.
- W4311356952 cites W4291465550 @default.
- W4311356952 cites W4294629153 @default.
- W4311356952 cites W4295442670 @default.
- W4311356952 cites W4297093900 @default.
- W4311356952 cites W4297253567 @default.
- W4311356952 cites W4297340002 @default.
- W4311356952 doi "https://doi.org/10.3389/fimmu.2022.1065927" @default.
- W4311356952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36591293" @default.
- W4311356952 hasPublicationYear "2022" @default.
- W4311356952 type Work @default.
- W4311356952 citedByCount "2" @default.
- W4311356952 countsByYear W43113569522023 @default.
- W4311356952 crossrefType "journal-article" @default.
- W4311356952 hasAuthorship W4311356952A5015544231 @default.
- W4311356952 hasAuthorship W4311356952A5025850836 @default.
- W4311356952 hasAuthorship W4311356952A5046173951 @default.
- W4311356952 hasAuthorship W4311356952A5050921331 @default.
- W4311356952 hasAuthorship W4311356952A5071170713 @default.
- W4311356952 hasAuthorship W4311356952A5077352796 @default.
- W4311356952 hasBestOaLocation W43113569521 @default.
- W4311356952 hasConcept C121608353 @default.
- W4311356952 hasConcept C134018914 @default.
- W4311356952 hasConcept C2776107976 @default.
- W4311356952 hasConcept C2776991927 @default.
- W4311356952 hasConcept C4733338 @default.
- W4311356952 hasConcept C502942594 @default.
- W4311356952 hasConcept C54355233 @default.
- W4311356952 hasConcept C62231903 @default.
- W4311356952 hasConcept C71924100 @default.
- W4311356952 hasConcept C86803240 @default.
- W4311356952 hasConceptScore W4311356952C121608353 @default.
- W4311356952 hasConceptScore W4311356952C134018914 @default.
- W4311356952 hasConceptScore W4311356952C2776107976 @default.
- W4311356952 hasConceptScore W4311356952C2776991927 @default.
- W4311356952 hasConceptScore W4311356952C4733338 @default.
- W4311356952 hasConceptScore W4311356952C502942594 @default.
- W4311356952 hasConceptScore W4311356952C54355233 @default.
- W4311356952 hasConceptScore W4311356952C62231903 @default.
- W4311356952 hasConceptScore W4311356952C71924100 @default.
- W4311356952 hasConceptScore W4311356952C86803240 @default.
- W4311356952 hasLocation W43113569521 @default.
- W4311356952 hasLocation W43113569522 @default.
- W4311356952 hasLocation W43113569523 @default.
- W4311356952 hasLocation W43113569524 @default.
- W4311356952 hasOpenAccess W4311356952 @default.
- W4311356952 hasPrimaryLocation W43113569521 @default.
- W4311356952 hasRelatedWork W2365364931 @default.
- W4311356952 hasRelatedWork W2418638721 @default.
- W4311356952 hasRelatedWork W2605923420 @default.
- W4311356952 hasRelatedWork W2771066073 @default.
- W4311356952 hasRelatedWork W2810786508 @default.
- W4311356952 hasRelatedWork W3106886521 @default.