FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311357411> ?p ?o ?g. }

• W4311357411 endingPage "15824" @default.
• W4311357411 startingPage "15824" @default.
• W4311357411 abstract "Protein domains are independent structural and functional modules that can rearrange to create new proteins. While the evolution of multidomain proteins through the shuffling of different preexisting domains has been well documented, the evolution of domain repeat proteins and the origin of new domains are less understood. Metallothioneins (MTs) provide a good case study considering that they consist of metal-binding domain repeats, some of them with a likely de novo origin. In mollusks, for instance, most MTs are bidomain proteins that arose by lineage-specific rearrangements between six putative domains: α, β1, β2, β3, γ and δ. Some domains have been characterized in bivalves and gastropods, but nothing is known about the MTs and their domains of other Mollusca classes. To fill this gap, we investigated the metal-binding features of NpoMT1 of Nautilus pompilius (Cephalopoda class) and FcaMT1 of Falcidens caudatus (Caudofoveata class). Interestingly, whereas NpoMT1 consists of α and β1 domains and has a prototypical Cd2+ preference, FcaMT1 has a singular preference for Zn2+ ions and a distinct domain composition, including a new Caudofoveata-specific δ domain. Overall, our results suggest that the modular architecture of MTs has contributed to MT evolution during mollusk diversification, and exemplify how modularity increases MT evolvability." @default.
• W4311357411 created "2022-12-25" @default.
• W4311357411 creator A5009961261 @default.
• W4311357411 creator A5012028701 @default.
• W4311357411 creator A5021623575 @default.
• W4311357411 creator A5040775444 @default.
• W4311357411 creator A5059792777 @default.
• W4311357411 creator A5077952724 @default.
• W4311357411 creator A5078161933 @default.
• W4311357411 creator A5082653476 @default.
• W4311357411 date "2022-12-13" @default.
• W4311357411 modified "2023-10-16" @default.
• W4311357411 title "The Modular Architecture of Metallothioneins Facilitates Domain Rearrangements and Contributes to Their Evolvability in Metal-Accumulating Mollusks" @default.
• W4311357411 cites W1642801664 @default.
• W4311357411 cites W1968538659 @default.
• W4311357411 cites W1973722782 @default.
• W4311357411 cites W1986347357 @default.
• W4311357411 cites W1988261052 @default.
• W4311357411 cites W1990033177 @default.
• W4311357411 cites W1990056477 @default.
• W4311357411 cites W2005991299 @default.
• W4311357411 cites W2009607498 @default.
• W4311357411 cites W2031915653 @default.
• W4311357411 cites W2043092219 @default.
• W4311357411 cites W2044723609 @default.
• W4311357411 cites W2053964529 @default.
• W4311357411 cites W2055118532 @default.
• W4311357411 cites W2056793372 @default.
• W4311357411 cites W2058401582 @default.
• W4311357411 cites W2073785345 @default.
• W4311357411 cites W2083278094 @default.
• W4311357411 cites W2096745364 @default.
• W4311357411 cites W2097484079 @default.
• W4311357411 cites W2107185020 @default.
• W4311357411 cites W2112792893 @default.
• W4311357411 cites W2119885004 @default.
• W4311357411 cites W2126740905 @default.
• W4311357411 cites W2128774397 @default.
• W4311357411 cites W2129883957 @default.
• W4311357411 cites W2130581715 @default.
• W4311357411 cites W2161033884 @default.
• W4311357411 cites W2163970776 @default.
• W4311357411 cites W2205343347 @default.
• W4311357411 cites W2346724200 @default.
• W4311357411 cites W2525339465 @default.
• W4311357411 cites W2588915083 @default.
• W4311357411 cites W2626853519 @default.
• W4311357411 cites W2732437167 @default.
• W4311357411 cites W2890006537 @default.
• W4311357411 cites W2893254544 @default.
• W4311357411 cites W3008265590 @default.
• W4311357411 cites W3009646777 @default.
• W4311357411 cites W3011846437 @default.
• W4311357411 cites W3012951261 @default.
• W4311357411 cites W3086741367 @default.
• W4311357411 cites W3123647022 @default.
• W4311357411 cites W3168952493 @default.
• W4311357411 cites W3184003565 @default.
• W4311357411 cites W4200209982 @default.
• W4311357411 cites W4211238482 @default.
• W4311357411 cites W4286423350 @default.
• W4311357411 cites W4286447590 @default.
• W4311357411 cites W4310333365 @default.
• W4311357411 cites W80140380 @default.
• W4311357411 doi "https://doi.org/10.3390/ijms232415824" @default.
• W4311357411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36555472" @default.
• W4311357411 hasPublicationYear "2022" @default.
• W4311357411 type Work @default.
• W4311357411 citedByCount "1" @default.
• W4311357411 crossrefType "journal-article" @default.
• W4311357411 hasAuthorship W4311357411A5009961261 @default.
• W4311357411 hasAuthorship W4311357411A5012028701 @default.
• W4311357411 hasAuthorship W4311357411A5021623575 @default.
• W4311357411 hasAuthorship W4311357411A5040775444 @default.
• W4311357411 hasAuthorship W4311357411A5059792777 @default.
• W4311357411 hasAuthorship W4311357411A5077952724 @default.
• W4311357411 hasAuthorship W4311357411A5078161933 @default.
• W4311357411 hasAuthorship W4311357411A5082653476 @default.
• W4311357411 hasBestOaLocation W43113574111 @default.
• W4311357411 hasConcept C104317684 @default.
• W4311357411 hasConcept C144292202 @default.
• W4311357411 hasConcept C167927819 @default.
• W4311357411 hasConcept C176147130 @default.
• W4311357411 hasConcept C193252679 @default.
• W4311357411 hasConcept C199360897 @default.
• W4311357411 hasConcept C2776817793 @default.
• W4311357411 hasConcept C2779478453 @default.
• W4311357411 hasConcept C41008148 @default.
• W4311357411 hasConcept C54355233 @default.
• W4311357411 hasConcept C70721500 @default.
• W4311357411 hasConcept C78458016 @default.
• W4311357411 hasConcept C86803240 @default.
• W4311357411 hasConcept C90132467 @default.
• W4311357411 hasConceptScore W4311357411C104317684 @default.
• W4311357411 hasConceptScore W4311357411C144292202 @default.
• W4311357411 hasConceptScore W4311357411C167927819 @default.
• W4311357411 hasConceptScore W4311357411C176147130 @default.
• W4311357411 hasConceptScore W4311357411C193252679 @default.

• next