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• W4311357663 abstract "To develop a pre-treatment CT-based predictive model to anticipate inoperable lung cancer patients' progression-free survival (PFS) to immunotherapy. This single-center retrospective study developed and cross-validated a radiomic model in 185 patients and tested it in 48 patients. The binary endpoint is the durable clinical benefit (DCB, PFS ≥ 6 months) and non-DCB (NDCB, PFS < 6 months). Radiomic features were extracted from multiple intrapulmonary lesions and weighted by an attention-based multiple-instance learning model. Aggregated features were then selected through L2-regularized ridge regression. Five machine-learning classifiers were conducted to build predictive models using radiomic and clinical features alone and then together. Lastly, the predictive value of the model with the best performance was validated by Kaplan-Meier survival analysis. The predictive models based on the weighted radiomic approach showed superior performance across all classifiers (AUCs: 0.75–0.82) compared with the largest lesion approach (AUCs: 0.70–0.78) and the average sum approach (AUCs: 0.64–0.80). Among them, the logistic regression model yielded the most balanced performance (AUC = 0.87 [95%CI 0.84–0.89], 0.75 [0.68–0.82], 0.80 [0.68-0.92] in the training, validation, and test cohort respectively). The addition of five clinical characteristics significantly enhanced the performance of radiomic-only model (train: AUC 0.91 [0.89–0.93], p = .042; validation: AUC 0.86 [0.80–0.91], p = .011; test: AUC 0.86 [0.76–0.96], p = .026). Kaplan-Meier analysis of the radiomic-based predictive models showed a clear stratification between classifier-predicted DCB versus NDCB for PFS (HR = 2.40–2.95, p < 0.05). The adoption of weighted radiomic features from multiple intrapulmonary lesions has the potential to predict long-term PFS benefits for patients who are candidates for PD-1/PD-L1 immunotherapies. • Weighted radiomic-based model derived from multiple intrapulmonary lesions on pre-treatment CT images has the potential to predict durable clinical benefits of immunotherapy in lung cancer. • Early line immunotherapy is associated with longer progression-free survival in advanced lung cancer." @default.
• W4311357663 created "2022-12-25" @default.
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• W4311357663 date "2022-12-14" @default.
• W4311357663 modified "2023-09-30" @default.
• W4311357663 title "A pre-treatment CT-based weighted radiomic approach combined with clinical characteristics to predict durable clinical benefits of immunotherapy in advanced lung cancer" @default.
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• W4311357663 doi "https://doi.org/10.1007/s00330-022-09337-7" @default.
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