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- W4311358637 endingPage "15859" @default.
- W4311358637 startingPage "15859" @default.
- W4311358637 abstract "Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In addition, astrocytes are capable of releasing several biologically active substances, including glutamate and GABA. Astrocyte-mediated GABA release has been a matter of debate because the expression level of the main GABA synthesizing enzyme glutamate decarboxylase is quite low in astrocytes, suggesting that low intracellular GABA concentration ([GABA]i) might be insufficient to support a non-vesicular GABA release. However, recent studies demonstrated that, at least in some regions of the CNS, [GABA]i in astrocytes might reach several millimoles both under physiological and especially pathophysiological conditions, thereby enabling GABA release from astrocytes via GABA-permeable anion channels and/or via GABA transporters operating in reverse mode. In this review, we summarize experimental data supporting both forms of GABA release from astrocytes in health and disease, paying special attention to possible feedback mechanisms that might govern the fine-tuning of astrocytic GABA release and, in turn, the tonic GABAA receptor-mediated inhibition in the CNS." @default.
- W4311358637 created "2022-12-25" @default.
- W4311358637 creator A5035396519 @default.
- W4311358637 creator A5060656155 @default.
- W4311358637 date "2022-12-13" @default.
- W4311358637 modified "2023-10-02" @default.
- W4311358637 title "GABA Release from Astrocytes in Health and Disease" @default.
- W4311358637 cites W1501706589 @default.
- W4311358637 cites W1516426911 @default.
- W4311358637 cites W1541267199 @default.
- W4311358637 cites W1583603147 @default.
- W4311358637 cites W1592670499 @default.
- W4311358637 cites W1594253922 @default.
- W4311358637 cites W1816535894 @default.
- W4311358637 cites W1892249233 @default.
- W4311358637 cites W1905103140 @default.
- W4311358637 cites W1936866440 @default.
- W4311358637 cites W1953286546 @default.
- W4311358637 cites W1970124769 @default.
- W4311358637 cites W1974016987 @default.
- W4311358637 cites W1974582869 @default.
- W4311358637 cites W1974626059 @default.
- W4311358637 cites W1980090196 @default.
- W4311358637 cites W1983374955 @default.
- W4311358637 cites W1985097707 @default.
- W4311358637 cites W1989236011 @default.
- W4311358637 cites W1989407074 @default.
- W4311358637 cites W1990673766 @default.
- W4311358637 cites W1991077451 @default.
- W4311358637 cites W2000225222 @default.
- W4311358637 cites W2005530893 @default.
- W4311358637 cites W2009460169 @default.
- W4311358637 cites W2009738449 @default.
- W4311358637 cites W2013688792 @default.
- W4311358637 cites W2014424306 @default.
- W4311358637 cites W2015236906 @default.
- W4311358637 cites W2016575029 @default.
- W4311358637 cites W2017523469 @default.
- W4311358637 cites W2030230530 @default.
- W4311358637 cites W2035077079 @default.
- W4311358637 cites W2042199639 @default.
- W4311358637 cites W2042315877 @default.
- W4311358637 cites W2044107589 @default.
- W4311358637 cites W2045481256 @default.
- W4311358637 cites W2048383480 @default.
- W4311358637 cites W2052878106 @default.
- W4311358637 cites W2053739364 @default.
- W4311358637 cites W2058657253 @default.
- W4311358637 cites W2064907262 @default.
- W4311358637 cites W2065031748 @default.
- W4311358637 cites W2067102106 @default.
- W4311358637 cites W2072462647 @default.
- W4311358637 cites W2072652550 @default.
- W4311358637 cites W2074792377 @default.
- W4311358637 cites W2079809458 @default.
- W4311358637 cites W2082436201 @default.
- W4311358637 cites W2087356150 @default.
- W4311358637 cites W2089193694 @default.
- W4311358637 cites W2090832170 @default.
- W4311358637 cites W2090971379 @default.
- W4311358637 cites W2093493094 @default.
- W4311358637 cites W2096230518 @default.
- W4311358637 cites W2102747751 @default.
- W4311358637 cites W2106100119 @default.
- W4311358637 cites W2109078104 @default.
- W4311358637 cites W2109345000 @default.
- W4311358637 cites W2109909801 @default.
- W4311358637 cites W2112075758 @default.
- W4311358637 cites W2114958991 @default.
- W4311358637 cites W2118546680 @default.
- W4311358637 cites W2118915904 @default.
- W4311358637 cites W2124017577 @default.
- W4311358637 cites W2126876161 @default.
- W4311358637 cites W2129830561 @default.
- W4311358637 cites W2131584208 @default.
- W4311358637 cites W2133743587 @default.
- W4311358637 cites W2135573968 @default.
- W4311358637 cites W2137976898 @default.
- W4311358637 cites W2138384280 @default.
- W4311358637 cites W2143933349 @default.
- W4311358637 cites W2152043542 @default.
- W4311358637 cites W2152344341 @default.
- W4311358637 cites W2158397025 @default.
- W4311358637 cites W2160557453 @default.
- W4311358637 cites W2160644313 @default.
- W4311358637 cites W2161487559 @default.
- W4311358637 cites W2170208972 @default.
- W4311358637 cites W2170644095 @default.
- W4311358637 cites W2260140125 @default.
- W4311358637 cites W2307837122 @default.
- W4311358637 cites W2320983896 @default.
- W4311358637 cites W2328485626 @default.
- W4311358637 cites W2338983518 @default.
- W4311358637 cites W2477292308 @default.
- W4311358637 cites W2487049220 @default.
- W4311358637 cites W2551662476 @default.
- W4311358637 cites W2582688531 @default.
- W4311358637 cites W2607241850 @default.