FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311360312> ?p ?o ?g. }

• W4311360312 endingPage "121064" @default.
• W4311360312 startingPage "121064" @default.
• W4311360312 abstract "By laser monitoring method, the solid–liquid phase equilibrium solubility of Nintedanib esylate in the four binary mixtures (including methanol (MeOH) + ethyl acetate (EtOAC), N,N-Dimethylformamide(DMF) + ethyl acetate (EtOAC), N,N-Dimethylacetamide (DMAC) + ethyl acetate (EtOAC), and methanol (MeOH) + methyl tert-butyl ether(MTBE)) was achieved at different temperatures and atmospheric pressure. The result demonstrated that the solubility in the four binary mixed solvents was positively correlated with temperature and the mass fractions of DMAC, DMF and MeOH at a certain temperature. Correlation fitting was performed for the solubility data through Apleblat model, Ma model, λh model, CNIBS/R-K model and NRTL model, and the result showed that the CNIBS/R-K model had much lower relative average deviations than the others for the four solvents being researched. By using RDF and MD simulation, the intermolecular interactions of Nintedanib esylate and the chosen solvents proved that the ranks of the interactions between solute and solvent, as well as solvent and solvent, were bound up with the order of the saturation solubility of Nintedanib esylate in the chosen solvents. The calculation of Hansen solubility parameters of the solute molecules showed that the Hansen solubility parameters could explain the solubility of the solute in the four binary solvents and the solubility of the solute in the four binary solvents was affected by various factors such as dispersion force, hydrogen bond force and polarity force between molecules. The NRTL model and Van't Hoff equation were used to calculate the thermodynamic properties of the solute mixing process and the apparent thermodynamics of the solute dissolution process in the mixed solvent. The results show that: The mixing process of Nintedanib esylate in the selected four mixed solvents is spontaneous and entropy increasing process, and the dissolution process is enthalpy driven, endothermic and non-spontaneous process." @default.
• W4311360312 created "2022-12-25" @default.
• W4311360312 creator A5002960600 @default.
• W4311360312 creator A5005942959 @default.
• W4311360312 creator A5037753658 @default.
• W4311360312 creator A5051576580 @default.
• W4311360312 creator A5070749354 @default.
• W4311360312 creator A5071037763 @default.
• W4311360312 creator A5081085463 @default.
• W4311360312 creator A5086326013 @default.
• W4311360312 date "2023-03-01" @default.
• W4311360312 modified "2023-10-18" @default.
• W4311360312 title "Measuring Nintedanib esylate solubility in binary mixed solvents: Molecular dynamic simulation, solid-liquid phase equilibrium and thermodynamic analysis" @default.
• W4311360312 cites W1551729708 @default.
• W4311360312 cites W1611905620 @default.
• W4311360312 cites W1970977603 @default.
• W4311360312 cites W1971721583 @default.
• W4311360312 cites W2011927025 @default.
• W4311360312 cites W2014689880 @default.
• W4311360312 cites W2046577852 @default.
• W4311360312 cites W2120791222 @default.
• W4311360312 cites W2171250148 @default.
• W4311360312 cites W2286175291 @default.
• W4311360312 cites W2492289546 @default.
• W4311360312 cites W2546610634 @default.
• W4311360312 cites W2725635157 @default.
• W4311360312 cites W2773906894 @default.
• W4311360312 cites W2778973367 @default.
• W4311360312 cites W2892621126 @default.
• W4311360312 cites W2894574764 @default.
• W4311360312 cites W2923393921 @default.
• W4311360312 cites W2925857104 @default.
• W4311360312 cites W2944651785 @default.
• W4311360312 cites W2951050136 @default.
• W4311360312 cites W2963868947 @default.
• W4311360312 cites W2990716025 @default.
• W4311360312 cites W2991317590 @default.
• W4311360312 cites W3000246774 @default.
• W4311360312 cites W3002171479 @default.
• W4311360312 cites W3007795275 @default.
• W4311360312 cites W3011930926 @default.
• W4311360312 cites W3023772884 @default.
• W4311360312 cites W3027856392 @default.
• W4311360312 cites W3038044164 @default.
• W4311360312 cites W3095265826 @default.
• W4311360312 cites W3097585007 @default.
• W4311360312 cites W3097725890 @default.
• W4311360312 cites W3120085995 @default.
• W4311360312 cites W3120494813 @default.
• W4311360312 cites W3122583424 @default.
• W4311360312 cites W3165269354 @default.
• W4311360312 cites W3170328379 @default.
• W4311360312 cites W3187157276 @default.
• W4311360312 cites W3193140493 @default.
• W4311360312 cites W3194560013 @default.
• W4311360312 cites W3208383667 @default.
• W4311360312 cites W3209122777 @default.
• W4311360312 cites W3210599338 @default.
• W4311360312 cites W3215993713 @default.
• W4311360312 cites W4205496586 @default.
• W4311360312 cites W4205712225 @default.
• W4311360312 cites W4210431873 @default.
• W4311360312 cites W4210631963 @default.
• W4311360312 cites W4221054572 @default.
• W4311360312 cites W4280638985 @default.
• W4311360312 cites W4281774556 @default.
• W4311360312 cites W4283214621 @default.
• W4311360312 cites W4286638659 @default.
• W4311360312 cites W4288056466 @default.
• W4311360312 doi "https://doi.org/10.1016/j.molliq.2022.121064" @default.
• W4311360312 hasPublicationYear "2023" @default.
• W4311360312 type Work @default.
• W4311360312 citedByCount "1" @default.
• W4311360312 countsByYear W43113603122023 @default.
• W4311360312 crossrefType "journal-article" @default.
• W4311360312 hasAuthorship W4311360312A5002960600 @default.
• W4311360312 hasAuthorship W4311360312A5005942959 @default.
• W4311360312 hasAuthorship W4311360312A5037753658 @default.
• W4311360312 hasAuthorship W4311360312A5051576580 @default.
• W4311360312 hasAuthorship W4311360312A5070749354 @default.
• W4311360312 hasAuthorship W4311360312A5071037763 @default.
• W4311360312 hasAuthorship W4311360312A5081085463 @default.
• W4311360312 hasAuthorship W4311360312A5086326013 @default.
• W4311360312 hasConcept C112887158 @default.
• W4311360312 hasConcept C121332964 @default.
• W4311360312 hasConcept C147789679 @default.
• W4311360312 hasConcept C155574463 @default.
• W4311360312 hasConcept C170961132 @default.
• W4311360312 hasConcept C178790620 @default.
• W4311360312 hasConcept C184651966 @default.
• W4311360312 hasConcept C185592680 @default.
• W4311360312 hasConcept C2779607525 @default.
• W4311360312 hasConcept C2779858419 @default.
• W4311360312 hasConcept C2780471494 @default.
• W4311360312 hasConcept C31057274 @default.
• W4311360312 hasConcept C32909587 @default.
• W4311360312 hasConcept C40117563 @default.
• W4311360312 hasConcept C97355855 @default.

• next