Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311365512> ?p ?o ?g. }
- W4311365512 abstract "Activin A (Act A) has been reported to promote oligodendrocyte progenitor cell (OPC) differentiation in vitro and improve neurological outcomes in adult mice. However, the roles and mechanisms of action of Act A in preterm brain injury are unknown. In the present study, P5 rats were subjected to hypoxia‑ischemia to establish a neonatal white matter injury (WMI) model and Act A was injected via the lateral ventricle. Pathological characteristics, OPC differentiation, myelination, and neurological performance were analyzed. Further, the involvement of the Noggin/BMP4/Id2 signaling pathway in the roles of Act A in WMI was explored. Act A attenuated pathological damage, promoted OPC differentiation, enhanced myelin sheath and myelinated axon formation, and improved neurological performance of WMI rats. Moreover, Act A enhanced noggin expression, which, in turn, inhibited the expression of bone morphogenetic protein 4 (BMP4) and inhibitor of DNA binding 2 (Id2). Furthermore, upregulation of Id2 completely abolished the rescue effects of Act A in WMI rats. In conclusion, the present findings suggested that Act A rescues preterm brain injury via targeting a novel Noggin/BMP4/Id2 signaling pathway." @default.
- W4311365512 created "2022-12-25" @default.
- W4311365512 creator A5005794313 @default.
- W4311365512 creator A5009555060 @default.
- W4311365512 creator A5023789866 @default.
- W4311365512 creator A5033915750 @default.
- W4311365512 creator A5060655025 @default.
- W4311365512 creator A5065769386 @default.
- W4311365512 creator A5069957454 @default.
- W4311365512 date "2022-12-14" @default.
- W4311365512 modified "2023-10-15" @default.
- W4311365512 title "Activin A rescues preterm brain injury through a novel Noggin/BMP4/Id2 signaling pathway" @default.
- W4311365512 cites W1938046568 @default.
- W4311365512 cites W1974362837 @default.
- W4311365512 cites W1995501654 @default.
- W4311365512 cites W2035653659 @default.
- W4311365512 cites W2037578584 @default.
- W4311365512 cites W2041083111 @default.
- W4311365512 cites W2043364678 @default.
- W4311365512 cites W2046051277 @default.
- W4311365512 cites W2071796241 @default.
- W4311365512 cites W2076657057 @default.
- W4311365512 cites W2078602675 @default.
- W4311365512 cites W2079134736 @default.
- W4311365512 cites W2083927512 @default.
- W4311365512 cites W2085430872 @default.
- W4311365512 cites W2102912402 @default.
- W4311365512 cites W2147320392 @default.
- W4311365512 cites W2155471406 @default.
- W4311365512 cites W2158698668 @default.
- W4311365512 cites W2325937254 @default.
- W4311365512 cites W2469581423 @default.
- W4311365512 cites W2515633343 @default.
- W4311365512 cites W2535155938 @default.
- W4311365512 cites W2549863609 @default.
- W4311365512 cites W2614148033 @default.
- W4311365512 cites W2766971089 @default.
- W4311365512 cites W2788995220 @default.
- W4311365512 cites W2887809416 @default.
- W4311365512 cites W2913030106 @default.
- W4311365512 cites W2954465511 @default.
- W4311365512 cites W2988482730 @default.
- W4311365512 cites W3112950760 @default.
- W4311365512 doi "https://doi.org/10.3892/ijmm.2022.5215" @default.
- W4311365512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36524372" @default.
- W4311365512 hasPublicationYear "2022" @default.
- W4311365512 type Work @default.
- W4311365512 citedByCount "1" @default.
- W4311365512 countsByYear W43113655122023 @default.
- W4311365512 crossrefType "journal-article" @default.
- W4311365512 hasAuthorship W4311365512A5005794313 @default.
- W4311365512 hasAuthorship W4311365512A5009555060 @default.
- W4311365512 hasAuthorship W4311365512A5023789866 @default.
- W4311365512 hasAuthorship W4311365512A5033915750 @default.
- W4311365512 hasAuthorship W4311365512A5060655025 @default.
- W4311365512 hasAuthorship W4311365512A5065769386 @default.
- W4311365512 hasAuthorship W4311365512A5069957454 @default.
- W4311365512 hasBestOaLocation W43113655121 @default.
- W4311365512 hasConcept C104317684 @default.
- W4311365512 hasConcept C126322002 @default.
- W4311365512 hasConcept C127561419 @default.
- W4311365512 hasConcept C134018914 @default.
- W4311365512 hasConcept C2778761762 @default.
- W4311365512 hasConcept C2781316418 @default.
- W4311365512 hasConcept C31507581 @default.
- W4311365512 hasConcept C502942594 @default.
- W4311365512 hasConcept C55493867 @default.
- W4311365512 hasConcept C62478195 @default.
- W4311365512 hasConcept C71924100 @default.
- W4311365512 hasConcept C86803240 @default.
- W4311365512 hasConcept C95444343 @default.
- W4311365512 hasConceptScore W4311365512C104317684 @default.
- W4311365512 hasConceptScore W4311365512C126322002 @default.
- W4311365512 hasConceptScore W4311365512C127561419 @default.
- W4311365512 hasConceptScore W4311365512C134018914 @default.
- W4311365512 hasConceptScore W4311365512C2778761762 @default.
- W4311365512 hasConceptScore W4311365512C2781316418 @default.
- W4311365512 hasConceptScore W4311365512C31507581 @default.
- W4311365512 hasConceptScore W4311365512C502942594 @default.
- W4311365512 hasConceptScore W4311365512C55493867 @default.
- W4311365512 hasConceptScore W4311365512C62478195 @default.
- W4311365512 hasConceptScore W4311365512C71924100 @default.
- W4311365512 hasConceptScore W4311365512C86803240 @default.
- W4311365512 hasConceptScore W4311365512C95444343 @default.
- W4311365512 hasIssue "2" @default.
- W4311365512 hasLocation W43113655121 @default.
- W4311365512 hasLocation W43113655122 @default.
- W4311365512 hasLocation W43113655123 @default.
- W4311365512 hasOpenAccess W4311365512 @default.
- W4311365512 hasPrimaryLocation W43113655121 @default.
- W4311365512 hasRelatedWork W2020449916 @default.
- W4311365512 hasRelatedWork W2025703417 @default.
- W4311365512 hasRelatedWork W2033763031 @default.
- W4311365512 hasRelatedWork W2066083429 @default.
- W4311365512 hasRelatedWork W2107729314 @default.
- W4311365512 hasRelatedWork W2142172230 @default.
- W4311365512 hasRelatedWork W2164790835 @default.
- W4311365512 hasRelatedWork W2409608972 @default.
- W4311365512 hasRelatedWork W4220896095 @default.
- W4311365512 hasRelatedWork W4280554871 @default.