Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311365875> ?p ?o ?g. }
- W4311365875 endingPage "513" @default.
- W4311365875 startingPage "506" @default.
- W4311365875 abstract "The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing factors, especially amyloid-β (Aβ) aggregation. Bioorthogonal reactions provide a general, facile, and robust route for the localization and derivatization of Aβ-targeted agents. Herein, a pair of chiral alkyne-containing metallohelices (ΛA and ΔA) were demonstrated to enantioselectively target and modulate Aβ aggregation, which has been monitored in triple-transgenic AD model mice and proved to improve cognitive function. Compared with its enantiomer ΔA, ΛA performed better in blocking Aβ fibrillation, relieving Aβ-triggered toxicity, and recovering memory deficits in vivo. Moreover, clickable ΛA could act as a functional module for subsequent visualization and versatile modification of amyloid via bioorthogonal reaction. As a proof-of-concept, thioflavin T, tacrine, and magnetic nanoparticles were conjugated with ΛA to realize Aβ photo-oxygenation, acetylcholinesterase inhibition, and Aβ clearance, respectively. This proof-of-principle work provided new insights into the biolabeling and bioconjugation of multifunctional metallosupramolecules through click reactions for AD therapy." @default.
- W4311365875 created "2022-12-25" @default.
- W4311365875 creator A5006798023 @default.
- W4311365875 creator A5023074351 @default.
- W4311365875 creator A5034172662 @default.
- W4311365875 creator A5034711601 @default.
- W4311365875 creator A5051839885 @default.
- W4311365875 creator A5056217450 @default.
- W4311365875 creator A5065069789 @default.
- W4311365875 creator A5090202020 @default.
- W4311365875 date "2023-01-01" @default.
- W4311365875 modified "2023-10-17" @default.
- W4311365875 title "<i>In vivo</i> visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices" @default.
- W4311365875 cites W1969239697 @default.
- W4311365875 cites W1982034770 @default.
- W4311365875 cites W1995272223 @default.
- W4311365875 cites W2022756726 @default.
- W4311365875 cites W2026764545 @default.
- W4311365875 cites W2033357990 @default.
- W4311365875 cites W2039206392 @default.
- W4311365875 cites W2061587003 @default.
- W4311365875 cites W2065100984 @default.
- W4311365875 cites W2065262102 @default.
- W4311365875 cites W2065505692 @default.
- W4311365875 cites W2071908148 @default.
- W4311365875 cites W2077267667 @default.
- W4311365875 cites W2106301585 @default.
- W4311365875 cites W2143526232 @default.
- W4311365875 cites W2146910635 @default.
- W4311365875 cites W2150737519 @default.
- W4311365875 cites W2156916967 @default.
- W4311365875 cites W2193672635 @default.
- W4311365875 cites W2277388251 @default.
- W4311365875 cites W2310415701 @default.
- W4311365875 cites W2319211999 @default.
- W4311365875 cites W2335327790 @default.
- W4311365875 cites W2343878936 @default.
- W4311365875 cites W2472664892 @default.
- W4311365875 cites W2487848811 @default.
- W4311365875 cites W2530342154 @default.
- W4311365875 cites W2542856291 @default.
- W4311365875 cites W2552468098 @default.
- W4311365875 cites W2555332218 @default.
- W4311365875 cites W2622233487 @default.
- W4311365875 cites W2735416135 @default.
- W4311365875 cites W2769877684 @default.
- W4311365875 cites W2786863591 @default.
- W4311365875 cites W2787358449 @default.
- W4311365875 cites W2791696595 @default.
- W4311365875 cites W2844935039 @default.
- W4311365875 cites W2886819196 @default.
- W4311365875 cites W2903437882 @default.
- W4311365875 cites W2904959165 @default.
- W4311365875 cites W2913905783 @default.
- W4311365875 cites W2933954639 @default.
- W4311365875 cites W2958110014 @default.
- W4311365875 cites W2973320710 @default.
- W4311365875 cites W2973598512 @default.
- W4311365875 cites W2975801780 @default.
- W4311365875 cites W2999522562 @default.
- W4311365875 cites W3006829890 @default.
- W4311365875 cites W3012443652 @default.
- W4311365875 cites W3043596632 @default.
- W4311365875 cites W3113078272 @default.
- W4311365875 cites W3119432177 @default.
- W4311365875 cites W3156313548 @default.
- W4311365875 cites W3188684290 @default.
- W4311365875 cites W3198280879 @default.
- W4311365875 cites W3209799485 @default.
- W4311365875 cites W4220692946 @default.
- W4311365875 cites W4220825176 @default.
- W4311365875 cites W4244353955 @default.
- W4311365875 cites W4280501811 @default.
- W4311365875 doi "https://doi.org/10.1039/d2sc05897a" @default.
- W4311365875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36741518" @default.
- W4311365875 hasPublicationYear "2023" @default.
- W4311365875 type Work @default.
- W4311365875 citedByCount "2" @default.
- W4311365875 countsByYear W43113658752023 @default.
- W4311365875 crossrefType "journal-article" @default.
- W4311365875 hasAuthorship W4311365875A5006798023 @default.
- W4311365875 hasAuthorship W4311365875A5023074351 @default.
- W4311365875 hasAuthorship W4311365875A5034172662 @default.
- W4311365875 hasAuthorship W4311365875A5034711601 @default.
- W4311365875 hasAuthorship W4311365875A5051839885 @default.
- W4311365875 hasAuthorship W4311365875A5056217450 @default.
- W4311365875 hasAuthorship W4311365875A5065069789 @default.
- W4311365875 hasAuthorship W4311365875A5090202020 @default.
- W4311365875 hasBestOaLocation W43113658751 @default.
- W4311365875 hasConcept C150903083 @default.
- W4311365875 hasConcept C179104552 @default.
- W4311365875 hasConcept C185592680 @default.
- W4311365875 hasConcept C207001950 @default.
- W4311365875 hasConcept C21951064 @default.
- W4311365875 hasConcept C23963754 @default.
- W4311365875 hasConcept C2777633098 @default.
- W4311365875 hasConcept C69610077 @default.
- W4311365875 hasConcept C86803240 @default.