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- W4311373362 abstract "ABCA7 encodes an ATP-binding cassette transporter, and its loss-of-function variants are associated with Alzheimer's disease. To investigate the role of ABCA7 deficiency in the pathogenesis of Alzheimer's disease, we generated a homozygous ABCA7-knockout induced pluripotent stem cell (iPSC) line using CRISPR/Cas9-mediated gene editing. This ABCA7-deficient iPSC line maintains a normal karyotype, expression of pluripotency markers, and trilineage differentiation capacity." @default.
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- W4311373362 date "2023-02-01" @default.
- W4311373362 modified "2023-10-03" @default.
- W4311373362 title "Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system" @default.
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- W4311373362 doi "https://doi.org/10.1016/j.scr.2022.103000" @default.
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