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- W4311376075 abstract "Non-small cell lung cancer (NSCLC) is increasingly being treated with targeted therapies. Savolitinib (Orpathys®) is highly selective mesenchymal epithelial transition (MET)-tyrosine kinase inhibitor (TKI), which is conditionally approved in China for advanced NSCLC with MET exon 14 skipping mutations (METex14). This article summarizes the clinical development of savolitinib, as a monotherapy in NSCLC with METex14 mutation and in combination with epidermal growth factor receptor (EGFR) inhibitor in post EGFR-TKI resistance NSCLC due to MET-based acquired resistance. Preclinical models demonstrated anti-tumor activities in MET-driven cancer cell line and xenograft tumor models. The Phase Ia/Ib study established an optimized, recommended phase II dose in Chinese NSCLC patients, while TATTON study of savolitinib plus osimertinib in patients with EGFR mutant, MET-amplified and TKI-progressed NSCLC showed beneficial efficacy with acceptable safety profile. In a pivotal phase II study, Chinese patients with pulmonary sarcomatoid carcinoma, brain metastasis and other NSCLC subtype positive for METex14 mutation showed notable responses and acceptable safety profile with savolitinib. Currently, results from ongoing clinical trials are eagerly anticipated to confirm the efficacious and safety benefits of savolitinib as monotherapy and in combination with EGFR-TKI in acquired resistance setting in advanced NSCLC and its subtypes with MET alterations." @default.
- W4311376075 created "2022-12-25" @default.
- W4311376075 creator A5000797717 @default.
- W4311376075 creator A5004928583 @default.
- W4311376075 creator A5068462362 @default.
- W4311376075 date "2022-12-12" @default.
- W4311376075 modified "2023-10-04" @default.
- W4311376075 title "Landscape of Savolitinib Development for the Treatment of Non-Small Cell Lung Cancer with MET Alteration—A Narrative Review" @default.
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- W4311376075 doi "https://doi.org/10.3390/cancers14246122" @default.
- W4311376075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36551608" @default.
- W4311376075 hasPublicationYear "2022" @default.
- W4311376075 type Work @default.