Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311378259> ?p ?o ?g. }
- W4311378259 endingPage "339" @default.
- W4311378259 startingPage "326" @default.
- W4311378259 abstract "Horizontal gene transfer is a powerful source of innovations in prokaryotes that can affect almost any cellular system, including microbial organelles. The formation of magnetosomes, one of the most sophisticated microbial mineral-containing organelles synthesized by magnetotactic bacteria for magnetic navigation in the environment, was also shown to be a horizontally transferrable trait. However, the mechanisms determining the fate of such genes in new hosts are not well understood, since non-adaptive gene acquisitions are typically rapidly lost and become unavailable for observation. This likely explains why gene clusters encoding magnetosome biosynthesis have never been observed in non-magnetotactic bacteria. Here, we report the first discovery of a horizontally inherited dormant gene clusters encoding biosynthesis of magnetosomes in a non-magnetotactic phototrophic bacterium Rhodovastum atsumiense. We show that these clusters were inactivated through transcriptional silencing and antisense RNA regulation, but retain functionality, as several genes were able to complement the orthologous deletions in a remotely related magnetotactic bacterium. The laboratory transfer of foreign magnetosome genes to R. atsumiense was found to endow the strain with magnetosome biosynthesis, but strong negative selection led to rapid loss of this trait upon subcultivation, highlighting the trait instability in this organism. Our results provide insight into the horizontal dissemination of gene clusters encoding complex prokaryotic organelles and illuminate the potential mechanisms of their genomic preservation in a dormant state." @default.
- W4311378259 created "2022-12-25" @default.
- W4311378259 creator A5001932856 @default.
- W4311378259 creator A5004970290 @default.
- W4311378259 creator A5016440913 @default.
- W4311378259 creator A5043822909 @default.
- W4311378259 creator A5060486755 @default.
- W4311378259 creator A5063794655 @default.
- W4311378259 creator A5073788800 @default.
- W4311378259 creator A5078955980 @default.
- W4311378259 creator A5086448761 @default.
- W4311378259 date "2022-12-14" @default.
- W4311378259 modified "2023-10-01" @default.
- W4311378259 title "Silent gene clusters encode magnetic organelle biosynthesis in a non-magnetotactic phototrophic bacterium" @default.
- W4311378259 cites W1787342281 @default.
- W4311378259 cites W1827213771 @default.
- W4311378259 cites W1966116114 @default.
- W4311378259 cites W1968146772 @default.
- W4311378259 cites W1968389858 @default.
- W4311378259 cites W1972740086 @default.
- W4311378259 cites W1978870027 @default.
- W4311378259 cites W1988102426 @default.
- W4311378259 cites W2007058060 @default.
- W4311378259 cites W2011301426 @default.
- W4311378259 cites W2022889543 @default.
- W4311378259 cites W2024976335 @default.
- W4311378259 cites W2026997417 @default.
- W4311378259 cites W2031945526 @default.
- W4311378259 cites W2040845548 @default.
- W4311378259 cites W2048345238 @default.
- W4311378259 cites W2065663412 @default.
- W4311378259 cites W2068569206 @default.
- W4311378259 cites W2070186781 @default.
- W4311378259 cites W2075392895 @default.
- W4311378259 cites W2075563069 @default.
- W4311378259 cites W2081676964 @default.
- W4311378259 cites W2082521980 @default.
- W4311378259 cites W2082920664 @default.
- W4311378259 cites W2086223994 @default.
- W4311378259 cites W2087765069 @default.
- W4311378259 cites W2098889266 @default.
- W4311378259 cites W2102278945 @default.
- W4311378259 cites W2104005232 @default.
- W4311378259 cites W2104488640 @default.
- W4311378259 cites W2107057546 @default.
- W4311378259 cites W2112364185 @default.
- W4311378259 cites W2115235560 @default.
- W4311378259 cites W2115590956 @default.
- W4311378259 cites W2116703454 @default.
- W4311378259 cites W2121433279 @default.
- W4311378259 cites W2121695290 @default.
- W4311378259 cites W2123350180 @default.
- W4311378259 cites W2128880918 @default.
- W4311378259 cites W2133074091 @default.
- W4311378259 cites W2134812217 @default.
- W4311378259 cites W2135683001 @default.
- W4311378259 cites W2136735268 @default.
- W4311378259 cites W2142389599 @default.
- W4311378259 cites W2150129048 @default.
- W4311378259 cites W2157748357 @default.
- W4311378259 cites W2160378127 @default.
- W4311378259 cites W2170551349 @default.
- W4311378259 cites W2171356409 @default.
- W4311378259 cites W2178637309 @default.
- W4311378259 cites W2341539131 @default.
- W4311378259 cites W2342249984 @default.
- W4311378259 cites W2419543643 @default.
- W4311378259 cites W2520157639 @default.
- W4311378259 cites W2588409318 @default.
- W4311378259 cites W2624680947 @default.
- W4311378259 cites W2625497208 @default.
- W4311378259 cites W2770907626 @default.
- W4311378259 cites W2791814671 @default.
- W4311378259 cites W2884729089 @default.
- W4311378259 cites W2951124785 @default.
- W4311378259 cites W2951775826 @default.
- W4311378259 cites W2951912016 @default.
- W4311378259 cites W2952167528 @default.
- W4311378259 cites W2964767026 @default.
- W4311378259 cites W2977760679 @default.
- W4311378259 cites W2981519702 @default.
- W4311378259 cites W3005235420 @default.
- W4311378259 cites W3008226193 @default.
- W4311378259 cites W3016288771 @default.
- W4311378259 cites W3029928583 @default.
- W4311378259 cites W3044992695 @default.
- W4311378259 cites W3045075556 @default.
- W4311378259 cites W3075036400 @default.
- W4311378259 cites W3080610554 @default.
- W4311378259 cites W3092802723 @default.
- W4311378259 cites W3095006384 @default.
- W4311378259 cites W3107062246 @default.
- W4311378259 cites W3150635270 @default.
- W4311378259 cites W3201492031 @default.
- W4311378259 cites W4289130404 @default.
- W4311378259 cites W4294216491 @default.
- W4311378259 doi "https://doi.org/10.1038/s41396-022-01348-y" @default.
- W4311378259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36517527" @default.