FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311381641> ?p ?o ?g. }

• W4311381641 abstract "Insertions and deletions (indels) of short DNA segments are common evolutionary events. Numerous studies showed that deletions occur more often than insertions in both prokaryotes and eukaryotes. It raises the question why neutral sequences are not eradicated from the genome. We suggest that this is due to a phenomenon we term border-induced selection. Accordingly, a neutral sequence is bordered between conserved regions. Deletions occurring near the borders occasionally protrude to the conserved region and are thereby subject to strong purifying selection. Thus, for short neutral sequences, an insertion bias is expected. Here, we develop a set of increasingly complex models of indel dynamics that incorporate border-induced selection. Furthermore, we show that short conserved sequences within the neutrally evolving sequence help explain: (i) the presence of very long sequences; (ii) the high variance of sequence lengths; and (iii) the possible emergence of multimodality in sequence length distributions. Finally, we fitted our models to the human intron length distribution, as introns are thought to be mostly neutral and bordered by conserved exons. We show that when accounting for the occurrence of short conserved sequences within introns, we reproduce the main features, including the presence of long introns and the multimodality of intron distribution." @default.
• W4311381641 created "2022-12-25" @default.
• W4311381641 creator A5024800697 @default.
• W4311381641 creator A5040966609 @default.
• W4311381641 creator A5043606014 @default.
• W4311381641 creator A5049114718 @default.
• W4311381641 creator A5070736617 @default.
• W4311381641 creator A5073537973 @default.
• W4311381641 date "2022-12-01" @default.
• W4311381641 modified "2023-09-26" @default.
• W4311381641 title "The evolutionary dynamics that retain long neutral genomic sequences in face of indel deletion bias: a model and its application to human introns" @default.
• W4311381641 cites W1968569455 @default.
• W4311381641 cites W1976760391 @default.
• W4311381641 cites W1988714210 @default.
• W4311381641 cites W1989508933 @default.
• W4311381641 cites W1995953877 @default.
• W4311381641 cites W2007413817 @default.
• W4311381641 cites W2011635997 @default.
• W4311381641 cites W2016588572 @default.
• W4311381641 cites W2033411792 @default.
• W4311381641 cites W2033771289 @default.
• W4311381641 cites W2042723151 @default.
• W4311381641 cites W2046457574 @default.
• W4311381641 cites W2051490611 @default.
• W4311381641 cites W2059178206 @default.
• W4311381641 cites W2063690908 @default.
• W4311381641 cites W2072398298 @default.
• W4311381641 cites W2079200508 @default.
• W4311381641 cites W2092979861 @default.
• W4311381641 cites W2110973918 @default.
• W4311381641 cites W2117502535 @default.
• W4311381641 cites W2119585200 @default.
• W4311381641 cites W2126740061 @default.
• W4311381641 cites W2129765241 @default.
• W4311381641 cites W2133988798 @default.
• W4311381641 cites W2138548684 @default.
• W4311381641 cites W2142961247 @default.
• W4311381641 cites W2142987298 @default.
• W4311381641 cites W2146222452 @default.
• W4311381641 cites W2146703483 @default.
• W4311381641 cites W2150623394 @default.
• W4311381641 cites W2152538475 @default.
• W4311381641 cites W2155418451 @default.
• W4311381641 cites W2160708989 @default.
• W4311381641 cites W2165064122 @default.
• W4311381641 cites W2178351989 @default.
• W4311381641 cites W2424772422 @default.
• W4311381641 cites W2492339642 @default.
• W4311381641 cites W2800207166 @default.
• W4311381641 cites W2921725714 @default.
• W4311381641 cites W2969452030 @default.
• W4311381641 cites W3103145119 @default.
• W4311381641 cites W3197918389 @default.
• W4311381641 cites W3217256122 @default.
• W4311381641 cites W4287578215 @default.
• W4311381641 cites W4311381641 @default.
• W4311381641 cites W575473521 @default.
• W4311381641 doi "https://doi.org/10.1098/rsob.220223" @default.
• W4311381641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36514983" @default.
• W4311381641 hasPublicationYear "2022" @default.
• W4311381641 type Work @default.
• W4311381641 citedByCount "1" @default.
• W4311381641 countsByYear W43113816412022 @default.
• W4311381641 crossrefType "journal-article" @default.
• W4311381641 hasAuthorship W4311381641A5024800697 @default.
• W4311381641 hasAuthorship W4311381641A5040966609 @default.
• W4311381641 hasAuthorship W4311381641A5043606014 @default.
• W4311381641 hasAuthorship W4311381641A5049114718 @default.
• W4311381641 hasAuthorship W4311381641A5070736617 @default.
• W4311381641 hasAuthorship W4311381641A5073537973 @default.
• W4311381641 hasBestOaLocation W43113816413 @default.
• W4311381641 hasConcept C104317684 @default.
• W4311381641 hasConcept C119054055 @default.
• W4311381641 hasConcept C135763542 @default.
• W4311381641 hasConcept C141231307 @default.
• W4311381641 hasConcept C153209595 @default.
• W4311381641 hasConcept C154945302 @default.
• W4311381641 hasConcept C197077220 @default.
• W4311381641 hasConcept C199216141 @default.
• W4311381641 hasConcept C2778112365 @default.
• W4311381641 hasConcept C2910714999 @default.
• W4311381641 hasConcept C3017666073 @default.
• W4311381641 hasConcept C36823959 @default.
• W4311381641 hasConcept C41008148 @default.
• W4311381641 hasConcept C54355233 @default.
• W4311381641 hasConcept C64554109 @default.
• W4311381641 hasConcept C70721500 @default.
• W4311381641 hasConcept C7386963 @default.
• W4311381641 hasConcept C78458016 @default.
• W4311381641 hasConcept C81917197 @default.
• W4311381641 hasConcept C86803240 @default.
• W4311381641 hasConcept C94671646 @default.
• W4311381641 hasConceptScore W4311381641C104317684 @default.
• W4311381641 hasConceptScore W4311381641C119054055 @default.
• W4311381641 hasConceptScore W4311381641C135763542 @default.
• W4311381641 hasConceptScore W4311381641C141231307 @default.
• W4311381641 hasConceptScore W4311381641C153209595 @default.
• W4311381641 hasConceptScore W4311381641C154945302 @default.
• W4311381641 hasConceptScore W4311381641C197077220 @default.
• W4311381641 hasConceptScore W4311381641C199216141 @default.

• next