FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311387072> ?p ?o ?g. }

• W4311387072 abstract "Prediction of drug-protein binding is critical for virtual drug screening. Many deep learning methods have been proposed to predict the drug-protein binding based on protein sequences and drug representation sequences. However, most existing methods extract features from protein and drug sequences separately. As a result, they can not learn the features characterizing the drug-protein interactions. In addition, the existing methods encode the protein (drug) sequence usually based on the assumption that each amino acid (atom) has the same contribution to the binding, ignoring different impacts of different amino acids (atoms) on the binding. However, the event of drug-protein binding usually occurs between conserved residue fragments in the protein sequence and atom fragments of the drug molecule. Therefore, a more comprehensive encoding strategy is required to extract information from the conserved fragments. In this paper, we propose a novel model, named FragDPI, to predict the drug-protein binding affinity. Unlike other methods, we encode the sequences based on the conserved fragments and encode the protein and drug into a unified vector. Moreover, we adopt a novel two-step training strategy to train FragDPI. The pre-training step is to learn the interactions between different fragments using unsupervised learning. The fine-tuning step is for predicting the binding affinities using supervised learning. The experiment results have illustrated the superiority of FragDPI." @default.
• W4311387072 created "2022-12-25" @default.
• W4311387072 creator A5001573523 @default.
• W4311387072 creator A5023118199 @default.
• W4311387072 creator A5024393567 @default.
• W4311387072 creator A5034089467 @default.
• W4311387072 creator A5039837606 @default.
• W4311387072 creator A5080125836 @default.
• W4311387072 date "2022-12-13" @default.
• W4311387072 modified "2023-10-12" @default.
• W4311387072 title "FragDPI: a novel drug-protein interaction prediction model based on fragment understanding and unified coding" @default.
• W4311387072 cites W1847895759 @default.
• W4311387072 cites W2002472871 @default.
• W4311387072 cites W2029348196 @default.
• W4311387072 cites W2052214665 @default.
• W4311387072 cites W2079416470 @default.
• W4311387072 cites W2093720054 @default.
• W4311387072 cites W2096864392 @default.
• W4311387072 cites W2102461176 @default.
• W4311387072 cites W2109991441 @default.
• W4311387072 cites W2125727465 @default.
• W4311387072 cites W2131347449 @default.
• W4311387072 cites W2144660603 @default.
• W4311387072 cites W2160205549 @default.
• W4311387072 cites W2163888620 @default.
• W4311387072 cites W2559132852 @default.
• W4311387072 cites W2785947426 @default.
• W4311387072 cites W2809216727 @default.
• W4311387072 cites W3004604833 @default.
• W4311387072 cites W3005428795 @default.
• W4311387072 cites W3015490653 @default.
• W4311387072 cites W3018980093 @default.
• W4311387072 cites W3021391231 @default.
• W4311387072 cites W3083130172 @default.
• W4311387072 cites W3109916301 @default.
• W4311387072 cites W3114162064 @default.
• W4311387072 cites W4205171481 @default.
• W4311387072 doi "https://doi.org/10.1007/s11704-022-2163-9" @default.
• W4311387072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36532946" @default.
• W4311387072 hasPublicationYear "2022" @default.
• W4311387072 type Work @default.
• W4311387072 citedByCount "1" @default.
• W4311387072 countsByYear W43113870722023 @default.
• W4311387072 crossrefType "journal-article" @default.
• W4311387072 hasAuthorship W4311387072A5001573523 @default.
• W4311387072 hasAuthorship W4311387072A5023118199 @default.
• W4311387072 hasAuthorship W4311387072A5024393567 @default.
• W4311387072 hasAuthorship W4311387072A5034089467 @default.
• W4311387072 hasAuthorship W4311387072A5039837606 @default.
• W4311387072 hasAuthorship W4311387072A5080125836 @default.
• W4311387072 hasBestOaLocation W43113870721 @default.
• W4311387072 hasConcept C10010492 @default.
• W4311387072 hasConcept C104317684 @default.
• W4311387072 hasConcept C119857082 @default.
• W4311387072 hasConcept C125411270 @default.
• W4311387072 hasConcept C154945302 @default.
• W4311387072 hasConcept C167625842 @default.
• W4311387072 hasConcept C17744445 @default.
• W4311387072 hasConcept C199539241 @default.
• W4311387072 hasConcept C2776359362 @default.
• W4311387072 hasConcept C2778112365 @default.
• W4311387072 hasConcept C2780035454 @default.
• W4311387072 hasConcept C41008148 @default.
• W4311387072 hasConcept C54355233 @default.
• W4311387072 hasConcept C60644358 @default.
• W4311387072 hasConcept C66746571 @default.
• W4311387072 hasConcept C70721500 @default.
• W4311387072 hasConcept C74187038 @default.
• W4311387072 hasConcept C86803240 @default.
• W4311387072 hasConcept C94625758 @default.
• W4311387072 hasConcept C98274493 @default.
• W4311387072 hasConceptScore W4311387072C10010492 @default.
• W4311387072 hasConceptScore W4311387072C104317684 @default.
• W4311387072 hasConceptScore W4311387072C119857082 @default.
• W4311387072 hasConceptScore W4311387072C125411270 @default.
• W4311387072 hasConceptScore W4311387072C154945302 @default.
• W4311387072 hasConceptScore W4311387072C167625842 @default.
• W4311387072 hasConceptScore W4311387072C17744445 @default.
• W4311387072 hasConceptScore W4311387072C199539241 @default.
• W4311387072 hasConceptScore W4311387072C2776359362 @default.
• W4311387072 hasConceptScore W4311387072C2778112365 @default.
• W4311387072 hasConceptScore W4311387072C2780035454 @default.
• W4311387072 hasConceptScore W4311387072C41008148 @default.
• W4311387072 hasConceptScore W4311387072C54355233 @default.
• W4311387072 hasConceptScore W4311387072C60644358 @default.
• W4311387072 hasConceptScore W4311387072C66746571 @default.
• W4311387072 hasConceptScore W4311387072C70721500 @default.
• W4311387072 hasConceptScore W4311387072C74187038 @default.
• W4311387072 hasConceptScore W4311387072C86803240 @default.
• W4311387072 hasConceptScore W4311387072C94625758 @default.
• W4311387072 hasConceptScore W4311387072C98274493 @default.
• W4311387072 hasIssue "5" @default.
• W4311387072 hasLocation W43113870721 @default.
• W4311387072 hasLocation W43113870722 @default.
• W4311387072 hasLocation W43113870723 @default.
• W4311387072 hasOpenAccess W4311387072 @default.
• W4311387072 hasPrimaryLocation W43113870721 @default.
• W4311387072 hasRelatedWork W136504859 @default.
• W4311387072 hasRelatedWork W176174999 @default.
• W4311387072 hasRelatedWork W2136173760 @default.

• next