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• W4311387218 abstract "We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department.A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50 with non-ST-segment elevation myocardial infarction (NSTEMI)) and 50 control group patients with non-cardiac chest pain were included in the study. A detailed anamnesis was taken, a physical examination was performed, and 12-lead electrocardiograms and venous blood samples were taken at the time of admission. Spexin levels were measured via enzyme-linked immunosorbent assay.Serum spexin levels were significantly lower in the AMI group than in the non-cardiac chest pain group (p<0.001). There was no significant difference in serum spexin levels between STEMI and NSTEMI patients (p=0.83). In receiver operating curve analysis, we detected 58% sensitivity, 76% specificity, 82.9% positive predictive value, and 47.5% negative predictive value with an optimal cutoff value of 532 pg/mL for the diagnosis of AMI.In this study, serum spexin levels were significantly lower in AMI patients compared to patients with non-cardiac chest pain. The decrease in spexin levels suggests that it has the potential to be used as a diagnostic marker in AMI patients.Naš cilj je bio da odredimo nivo speksina u serumu kod pacijenata sa akutnim infarktom miokarda (AMI) koji su primljeni na odeljenje urgentne medicine.U studiju je uključeno ukupno 100 pacijenata sa AMI (50 sa infarktom miokarda sa elevacijom ST segmenta (STEMI) i 50 pacijenata sa infarktom miokarda sa elevacijom non-ST segmenta (NSTEMI)) i 50 pacijenata kontrolne grupe sa bolom u grudima čiji uzrok nisu bili problemi sa srcem. Uzeta je detaljna anamneza, urađen je klinički pregled, a prilikom prijema su uzeti 12-kanalni elektro - kardio g rami i uzorci venske krvi. Nivoi speksina su mereni putem enzimskog imunosorbentnog testa.Nivoi speksina u serumu su bili značajno niži u grupi sa AMI nego u grupi koja nije imala srčani bol u grudima (p<0,001). Nije bilo značajne razlike u nivoima speksina u serumu između pacijenata sa STEMI i NSTEMI (p=0,83). U analizi ROC krive, smo detektovali 58% osetljivosti, 76% specifičnosti, 82,9% pozitivne prediktivne vrednosti i 47,5% negativne prediktivne vrednosti sa optimalnom graničnom vrednošcu od 532 pg/mL za dijagnozu AMI.U ovoj studiji, nivoi speksina u serumu su bili značajno niži kod pacijenata sa AMI u poređenju sa pacijentima sa bolom u grudima čiji uzrok nisu bili problemi sa srcem. Smanjenje nivoa speksina ukazuje da on ima potencijal da se koristi kao dijagnostički marker kod pacijenata sa AMI." @default.
• W4311387218 created "2022-12-25" @default.
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• W4311387218 date "2023-01-01" @default.
• W4311387218 modified "2023-10-12" @default.
• W4311387218 title "Spexin Level in Acute Myocardial Infarction in the Emergency Department" @default.
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• W4311387218 doi "https://doi.org/10.5937/jomb0-39485" @default.
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