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- W4311389640 endingPage "8819" @default.
- W4311389640 startingPage "8819" @default.
- W4311389640 abstract "Phloretin is a natural dihydrochalcone found in many fruits and vegetables, especially in apple tree leaves and the Manchurian apricots, exhibiting several therapeutic properties, such as antioxidant, antidiabetic, anti-inflammatory, and antitumor activities. In this review article, the diverse aspects of the anticancer potential of phloretin are addressed, presenting its antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities in many different preclinical cancer models. The fact that phloretin is a planar lipophilic polyphenol and, thus, a membrane-disrupting Pan-Assay Interference compound (PAIN) compromises the validity of the cell-based anticancer activities. Phloretin significantly reduces membrane dipole potential and, therefore, is expected to be able to activate a number of cellular signaling pathways in a non-specific way. In this way, the effects of this minor flavonoid on Bax and Bcl-2 proteins, caspases and MMPs, cytokines, and inflammatory enzymes are all analyzed in the current review. Moreover, besides the anticancer activities exerted by phloretin alone, its co-effects with conventional anticancer drugs are also under discussion. Therefore, this review presents a thorough overview of the preclinical anticancer potential of phloretin, allowing one to take the next steps in the development of novel drug candidates and move on to clinical trials." @default.
- W4311389640 created "2022-12-26" @default.
- W4311389640 creator A5002778605 @default.
- W4311389640 creator A5031394094 @default.
- W4311389640 creator A5031466145 @default.
- W4311389640 creator A5038940543 @default.
- W4311389640 creator A5053008837 @default.
- W4311389640 creator A5057031081 @default.
- W4311389640 creator A5063671057 @default.
- W4311389640 creator A5085290172 @default.
- W4311389640 creator A5088810129 @default.
- W4311389640 date "2022-12-12" @default.
- W4311389640 modified "2023-10-09" @default.
- W4311389640 title "Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions" @default.
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