Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311392034> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4311392034 endingPage "4042" @default.
- W4311392034 startingPage "4042" @default.
- W4311392034 abstract "Age-related protein truncation is a common process in long-lived proteins such as proteins found in the ocular lens. Major truncation products have been reported for soluble and membrane proteins of the lens, including small peptides that can accelerate protein aggregation. However, the spatial localization of age-related protein fragments in the lens has received only limited study. Imaging mass spectrometry (IMS) is an ideal tool for examining the spatial localization of protein products in tissues. In this study we used IMS to determine the spatial localization of small crystallin fragments in aged and cataractous lenses. Consistent with previous reports, the pro-aggregatory αA-crystallin 66-80 peptide as well as αA-crystallin 67-80 and γS-crystallin 167-178 were detected in normal lenses, but found to be increased in nuclear cataract regions. In addition, a series of γS-crystallin C-terminal peptides were observed to be mainly localized to cataractous regions and barely detected in transparent lenses. Other peptides, including abundant αA3-crystallin peptides were present in both normal and cataract lenses. The functional properties of these crystallin peptides remain unstudied; however, their cataract-specific localization suggests further studies are warranted." @default.
- W4311392034 created "2022-12-26" @default.
- W4311392034 creator A5019618222 @default.
- W4311392034 creator A5043823252 @default.
- W4311392034 creator A5055302996 @default.
- W4311392034 creator A5090194196 @default.
- W4311392034 date "2022-12-14" @default.
- W4311392034 modified "2023-10-14" @default.
- W4311392034 title "Imaging Cataract-Specific Peptides in Human Lenses" @default.
- W4311392034 cites W1428480121 @default.
- W4311392034 cites W1568231313 @default.
- W4311392034 cites W1944789189 @default.
- W4311392034 cites W1985983646 @default.
- W4311392034 cites W1992341964 @default.
- W4311392034 cites W2000758165 @default.
- W4311392034 cites W2000798225 @default.
- W4311392034 cites W2012697282 @default.
- W4311392034 cites W2020054871 @default.
- W4311392034 cites W2027677218 @default.
- W4311392034 cites W2031480359 @default.
- W4311392034 cites W2032652519 @default.
- W4311392034 cites W2044754760 @default.
- W4311392034 cites W2084775228 @default.
- W4311392034 cites W2102860297 @default.
- W4311392034 cites W2134109960 @default.
- W4311392034 cites W2410488834 @default.
- W4311392034 cites W2413349502 @default.
- W4311392034 cites W2464199198 @default.
- W4311392034 cites W2465168820 @default.
- W4311392034 cites W2472270761 @default.
- W4311392034 cites W2591302121 @default.
- W4311392034 cites W2770676323 @default.
- W4311392034 cites W2790148502 @default.
- W4311392034 cites W295490132 @default.
- W4311392034 cites W2983721232 @default.
- W4311392034 cites W2984058782 @default.
- W4311392034 cites W3180544591 @default.
- W4311392034 cites W3206557648 @default.
- W4311392034 cites W37370850 @default.
- W4311392034 cites W857701621 @default.
- W4311392034 doi "https://doi.org/10.3390/cells11244042" @default.
- W4311392034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36552806" @default.
- W4311392034 hasPublicationYear "2022" @default.
- W4311392034 type Work @default.
- W4311392034 citedByCount "1" @default.
- W4311392034 countsByYear W43113920342023 @default.
- W4311392034 crossrefType "journal-article" @default.
- W4311392034 hasAuthorship W4311392034A5019618222 @default.
- W4311392034 hasAuthorship W4311392034A5043823252 @default.
- W4311392034 hasAuthorship W4311392034A5055302996 @default.
- W4311392034 hasAuthorship W4311392034A5090194196 @default.
- W4311392034 hasBestOaLocation W43113920341 @default.
- W4311392034 hasConcept C104317684 @default.
- W4311392034 hasConcept C136238340 @default.
- W4311392034 hasConcept C151730666 @default.
- W4311392034 hasConcept C15336307 @default.
- W4311392034 hasConcept C167625842 @default.
- W4311392034 hasConcept C185592680 @default.
- W4311392034 hasConcept C2779281246 @default.
- W4311392034 hasConcept C2910669755 @default.
- W4311392034 hasConcept C55493867 @default.
- W4311392034 hasConcept C7263354 @default.
- W4311392034 hasConcept C86803240 @default.
- W4311392034 hasConcept C95444343 @default.
- W4311392034 hasConceptScore W4311392034C104317684 @default.
- W4311392034 hasConceptScore W4311392034C136238340 @default.
- W4311392034 hasConceptScore W4311392034C151730666 @default.
- W4311392034 hasConceptScore W4311392034C15336307 @default.
- W4311392034 hasConceptScore W4311392034C167625842 @default.
- W4311392034 hasConceptScore W4311392034C185592680 @default.
- W4311392034 hasConceptScore W4311392034C2779281246 @default.
- W4311392034 hasConceptScore W4311392034C2910669755 @default.
- W4311392034 hasConceptScore W4311392034C55493867 @default.
- W4311392034 hasConceptScore W4311392034C7263354 @default.
- W4311392034 hasConceptScore W4311392034C86803240 @default.
- W4311392034 hasConceptScore W4311392034C95444343 @default.
- W4311392034 hasIssue "24" @default.
- W4311392034 hasLocation W43113920341 @default.
- W4311392034 hasLocation W43113920342 @default.
- W4311392034 hasLocation W43113920343 @default.
- W4311392034 hasLocation W43113920344 @default.
- W4311392034 hasOpenAccess W4311392034 @default.
- W4311392034 hasPrimaryLocation W43113920341 @default.
- W4311392034 hasRelatedWork W100851876 @default.
- W4311392034 hasRelatedWork W122117590 @default.
- W4311392034 hasRelatedWork W1974019347 @default.
- W4311392034 hasRelatedWork W1992013489 @default.
- W4311392034 hasRelatedWork W2000704611 @default.
- W4311392034 hasRelatedWork W2027677218 @default.
- W4311392034 hasRelatedWork W2055854637 @default.
- W4311392034 hasRelatedWork W2100803627 @default.
- W4311392034 hasRelatedWork W2796806089 @default.
- W4311392034 hasRelatedWork W3016713734 @default.
- W4311392034 hasVolume "11" @default.
- W4311392034 isParatext "false" @default.
- W4311392034 isRetracted "false" @default.
- W4311392034 workType "article" @default.