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- W4311402169 abstract "Recent published clinical trial safety data showed that 41% of Alzheimer patients experienced amyloid-related imaging abnormalities (ARIA), marks of microhemorrhages and edema in the brain, following administration of Biogen's Aduhelm/aducanumab (amino acids 3-7 of the Aβ peptide). Similarly, Janssen/Pfizer's Bapineuzumab (amino acids 1-5 of the Aβ peptide) and Roche's Gantenerumab (amino acids 2-11/18-27 of the Aβ peptide) also displayed ARIA in clinical trials, including microhemorrhage and focal areas of inflammation or vasogenic edema, respectively. The molecular mechanisms underlying ARIA caused by therapeutic anti-Aβ antibodies remain largely unknown, however, recent reports demonstrated that therapeutic anti-prion antibodies activate neuronal allergenic proteomes following cross-linking cellular prion protein.Here, we report that treatment of human induced pluripotent stem cells- derived neurons (HSCN) from a non-demented donor, co-cultured with human primary microglia with anti-Aβ1-6, or anti-Aβ17-23 antibodies activate a significant number of allergenic-related proteins as assessed by mass spectrometry.Interestingly, a large proportion of the identified proteins included cytokines such as interleukin (IL)-4, IL-12, and IL-13 suggesting a type-1 hypersensitivity response. Following flow cytometry analysis, several proinflammatory cytokines were significantly elevated following anti-Aβ1-6, or anti-Aβ17-23 antibody treatment.These results justify further and more robust investigation of the molecular mechanisms of ARIA during immunotherapy study trials of AD.Allergenic-related proteins are often linked with Alzheimer's disease (AD). We investigated the effects of amyloid beta (Aβ) immunotherapy on stem cell derived neurons and primary neuronal cells co-cultured with microglia. Anti-Aβ antibody treatment of neurons or neurons co-cultured with microglia led to activation of a substantial number of allergenic-related genes. These allergenic-related genes are associated with endothelial dysfunction possibly responsible for ARIA." @default.
- W4311402169 created "2022-12-26" @default.
- W4311402169 creator A5011845415 @default.
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- W4311402169 creator A5078065585 @default.
- W4311402169 date "2022-12-14" @default.
- W4311402169 modified "2023-10-16" @default.
- W4311402169 title "Therapeutic anti‐amyloid β antibodies cause neuronal disturbances" @default.
- W4311402169 cites W1512112524 @default.
- W4311402169 cites W1816305379 @default.
- W4311402169 cites W1872738283 @default.
- W4311402169 cites W1884628951 @default.
- W4311402169 cites W1964680215 @default.
- W4311402169 cites W1978567629 @default.
- W4311402169 cites W1978924496 @default.
- W4311402169 cites W1980220254 @default.
- W4311402169 cites W1984879882 @default.
- W4311402169 cites W1992637685 @default.
- W4311402169 cites W1993409946 @default.
- W4311402169 cites W1999516517 @default.
- W4311402169 cites W2002181764 @default.
- W4311402169 cites W2005382389 @default.
- W4311402169 cites W2015484447 @default.
- W4311402169 cites W2017214029 @default.
- W4311402169 cites W2017671227 @default.
- W4311402169 cites W2018233207 @default.
- W4311402169 cites W2021573775 @default.
- W4311402169 cites W2024356223 @default.
- W4311402169 cites W2024917017 @default.
- W4311402169 cites W2025200379 @default.
- W4311402169 cites W2037831471 @default.
- W4311402169 cites W2038794565 @default.
- W4311402169 cites W2057053855 @default.
- W4311402169 cites W2063808031 @default.
- W4311402169 cites W2065136791 @default.
- W4311402169 cites W2072442310 @default.
- W4311402169 cites W2074176490 @default.
- W4311402169 cites W2078844044 @default.
- W4311402169 cites W2086572083 @default.
- W4311402169 cites W2093618654 @default.
- W4311402169 cites W2096401612 @default.
- W4311402169 cites W2103801060 @default.
- W4311402169 cites W2106591637 @default.
- W4311402169 cites W2117565014 @default.
- W4311402169 cites W2118753807 @default.
- W4311402169 cites W2119098586 @default.
- W4311402169 cites W2123404136 @default.
- W4311402169 cites W2131461080 @default.
- W4311402169 cites W2139253645 @default.
- W4311402169 cites W2146608733 @default.
- W4311402169 cites W2147037892 @default.
- W4311402169 cites W2157079522 @default.
- W4311402169 cites W2160701199 @default.
- W4311402169 cites W2161431688 @default.
- W4311402169 cites W2161919187 @default.
- W4311402169 cites W2166264384 @default.
- W4311402169 cites W2325707043 @default.
- W4311402169 cites W2474534968 @default.
- W4311402169 cites W2497667077 @default.
- W4311402169 cites W2510806376 @default.
- W4311402169 cites W2522746387 @default.
- W4311402169 cites W2525098889 @default.
- W4311402169 cites W2590552706 @default.
- W4311402169 cites W2616410130 @default.
- W4311402169 cites W2616932765 @default.
- W4311402169 cites W2619466966 @default.
- W4311402169 cites W2791554250 @default.
- W4311402169 cites W2795165696 @default.
- W4311402169 cites W2800202520 @default.
- W4311402169 cites W2807924341 @default.
- W4311402169 cites W2884391850 @default.
- W4311402169 cites W2888417453 @default.
- W4311402169 cites W2895430781 @default.
- W4311402169 cites W2909175137 @default.
- W4311402169 cites W2912592608 @default.
- W4311402169 cites W2918066696 @default.
- W4311402169 cites W2931599123 @default.
- W4311402169 cites W2953462294 @default.
- W4311402169 cites W2972508725 @default.
- W4311402169 cites W3011841989 @default.
- W4311402169 cites W3022066613 @default.
- W4311402169 cites W3087933914 @default.
- W4311402169 cites W3091654316 @default.
- W4311402169 cites W3138346400 @default.
- W4311402169 cites W3146088640 @default.
- W4311402169 cites W3146410983 @default.
- W4311402169 cites W3189245340 @default.
- W4311402169 cites W3191322062 @default.
- W4311402169 cites W3197592313 @default.
- W4311402169 cites W3203663965 @default.
- W4311402169 cites W3217122335 @default.
- W4311402169 cites W4200571312 @default.
- W4311402169 cites W4225679665 @default.
- W4311402169 cites W642101920 @default.
- W4311402169 doi "https://doi.org/10.1002/alz.12833" @default.