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- W4311403281 abstract "Currently, research on toxic effects of PCP Na is greatly insufficient. The aim of this study is to explore the toxic effects of PCP-Na for better conducting future work on PCP-Na toxicology. For this purpose, S. constricta adults were exposed to PCP-Na for toxicity testing. The results showed that PCP-Na could easily bioaccumulate in S. constricta and significantly affected both phrase I and II metabolism enzymes. Meanwhile, PCP-Na strongly activated antioxidant system and caused PC, LPO and DNA damage. In addition, neurotoxicity and immunotoxicity of PCP-Na was demonstrated in this study. Interestingly, we observed that PCP-Na significantly affected the expression of genes of electron transport chain and induced key enzymes of glycolysis, indicating that PCP-Na may act as an uncoupler of oxidative phosphorylation, interfering with energy supply and causing energy compensation. This study is the first to fully analyze and provide a new perspective on the toxicity of PCP-Na." @default.
- W4311403281 created "2022-12-26" @default.
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- W4311403281 date "2023-01-01" @default.
- W4311403281 modified "2023-10-01" @default.
- W4311403281 title "Study on the toxic effects of sodium pentachlorophenol (PCP–Na) on razor clam (Sinonovacula constricta)" @default.
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- W4311403281 doi "https://doi.org/10.1016/j.marenvres.2022.105845" @default.
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